| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Outline of Final Research Achievements |
AMP-activated protein kinase (AMPK) is the master regulator of metabolic pathways and energy homeostasis. A number of activators of AMPK have been developed to treat diabetic patients or to improve the performance of athletes. These reagents are powerful tool to delineate the role of AMPK. However, such small molecule activators are prone to cause off-target effects and not applicable for the targeted stimulation of specific cell types. Here, we developed an optogenetic tool that rapidly and reversibly controls the AMPK activity by light inducible protein clustering in mammalian cells.
|
