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Bacterial factors associated with variation of clinical picture in autoimmune-mediated neuropathies

Research Project

Project/Area Number 18K07115
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 49050:Bacteriology-related
Research InstitutionYamaguchi University

Principal Investigator

KOGA Michiaki  山口大学, 医学部附属病院, 講師 (60383014)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsギラン・バレー症候群 / フィッシャー症候群 / インフルエンザ桿菌 / カンピロバクター・ジェジュニ / サイトメガロウイルス / 糖脂質抗体 / カンピロバクター / ガングリオシド / リポオリゴ糖 / Campylobacter jejuni / ganglioside
Outline of Final Research Achievements

Fisher syndrome (FS) is a major clinical phenotype of Guillain-Barre syndrome. It is characterized neurologically by the triad of ophthalmoplegia, ataxia, and areflexia and immunologically by the frequent presence of anti-GQ1b IgG autoantibodies. There are some variation of clinical picture in FS, ranging from incomplete forms of FS, such as acute ophthalmoparesis without ataxia, to advanced form that included Bickerstaff brainstem encephalitis and FS/Guillain-Barre syndrome overlap. These diverse clinical features of FS are determined, at least partially, by the type of preceding infection. In clinical practice, cases of FS after cytomegalovirus infection especially should be actively treated, because they tended to progress to severe disability. Furthermore, cytomegalovirus-related FS appeared to be similar to Haemophilus influenzae- and Campylobacter jejuni-related FS regarding anti-GQ1b antibody-mediated pathogenesis as opposed to CMV-related Guillain-Barre syndrome.

Academic Significance and Societal Importance of the Research Achievements

自己免疫疾患であるギラン・バレー症候群の発症に、感染症が関与することは決定的である。感染症の予防が自己免疫疾患を未然に防ぐために重要である。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (48 results)

All 2021 2020 2019 2018

All Journal Article (27 results) (of which Peer Reviewed: 16 results,  Open Access: 2 results) Presentation (12 results) (of which Invited: 4 results) Book (9 results)

  • [Journal Article] 伝導ブロックを呈したANCA陰性好酸球性多発血管炎性肉芽腫症の74歳女性例2021

    • Author(s)
      本田真也 竹下幸男 古賀道明 佐藤亮太 尾本雅俊 神田 隆
    • Journal Title

      臨床神経

      Volume: 印刷中

    • NAID

      130008093305

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 軽症のギラン・バレー症候群2021

    • Author(s)
      古賀道明
    • Journal Title

      Peripheral Nerve末梢神経

      Volume: 印刷中

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 中枢神経サルコイドーシス2021

    • Author(s)
      古賀道明
    • Journal Title

      BRAIN and NERVE

      Volume: 印刷中

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 増大特集 神経疾患の診断における落とし穴-誤診を避けるために 末梢神経疾患2020

    • Author(s)
      松尾 欣哉、古賀 道明、神田 隆
    • Journal Title

      BRAIN and NERVE

      Volume: 72 Issue: 4 Pages: 381-386

    • DOI

      10.11477/mf.1416201536

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2020-04-01
    • Related Report
      2020 Annual Research Report
  • [Journal Article] Cognitive Impairment Caused by Isolated Adrenocorticotropic Hormone Deficiency without Other Hypo-adrenalism Signs - Autoimmune Encephalopathy Mimics2020

    • Author(s)
      Matsuo Kinya、Koga Michiaki、Oishi Mariko、Kawai Motoharu、Kanda Takashi
    • Journal Title

      Internal Medicine

      Volume: 59 Issue: 1 Pages: 119-120

    • DOI

      10.2169/internalmedicine.3234-19

    • NAID

      130007779242

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2020-01-01
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy and Safety of Rituximab in Refractory CIDP With or Without IgG4 Autoantibodies (RECIPE): Protocol for a Double-Blind, Randomized, Placebo-Controlled Clinical Trial2020

    • Author(s)
      Shimizu Shinobu、Iijima Masahiro、Fukami Yuki、Tamura Natsuko、Nakatochi Masahiro、Ando Masahiko、Nishi Ryoji、Koike Haruki、Kaida Kenichi、Koga Michiaki、Kanda Takashi、Ogata Hidenori、Kira Jun-Ichi、Mori Masahiro、Kuwabara Satoshi、Katsuno Masahisa
    • Journal Title

      JMIR Research Protocols

      Volume: 9 Issue: 4 Pages: e17117-e17117

    • DOI

      10.2196/17117

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] フィッシャー症候群と先行感染:臨床的な観点からのアプローチ2020

    • Author(s)
      古賀道明
    • Journal Title

      Peripheral Nerve末梢神経

      Volume: 31 Pages: 42-47

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of novel <i>WDR45</i> mutation with beta-propeller protein-associated neurodegeneration (BPAN) presenting asymmetrical extrapyramidal signs2020

    • Author(s)
      Sato Ryota、Koga Michiaki、Iwama Kazuhiro、Mizuguchi Tsuyoshi、Matsumoto Naomichi、Kanda Takashi
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 60 Issue: 5 Pages: 317-320

    • DOI

      10.5692/clinicalneurol.cn-001324

    • NAID

      130007847182

    • ISSN
      0009-918X, 1882-0654
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集 サルコイドーシス 末梢神経サルコイドーシス2020

    • Author(s)
      古賀 道明
    • Journal Title

      BRAIN and NERVE

      Volume: 72 Pages: 855-862

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 特集 サルコイドーシス 脊髄サルコイドーシス2020

    • Author(s)
      藤澤 美和子、古賀 道明、神田 隆
    • Journal Title

      BRAIN and NERVE

      Volume: 72 Pages: 845-853

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Efficacy and Safety of Rituximab in Refractory CIDP with or without IgG4 Autoantibodies (RECIPE): Protocol for a Double-Blind, Randomized, Placebo-Controlled Clinical Trial.2020

    • Author(s)
      Shimizu S, Iijima M, Fukami Y, Tamura N, Nakatochi M, Ando M, Nishi R, Koike H, Kaida K, Koga M, Kanda T, Ogata H, Kira JI, Mori M, Kuwabara S, Katsuno M
    • Journal Title

      JMIR Research Protocols

      Volume: in press

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 非対称性の錐体外路症候を呈した beta-propeller protein-associated 3 neurodegeneration の 34 歳女性例2020

    • Author(s)
      佐藤亮太 古賀道明 岩間一浩 水口 剛 松本直通 神田 隆
    • Journal Title

      臨床神経

      Volume: 印刷中

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 神経疾患の診断における落とし穴:誤診を避けるために:末梢神経疾患2020

    • Author(s)
      松尾欣哉 古賀道明 神田 隆
    • Journal Title

      Brain Nerve

      Volume: 印刷中

    • Related Report
      2019 Research-status Report
  • [Journal Article] 増刊号 検査項目と異常値からみた-緊急・重要疾患レッドページ 2章 脳神経・筋疾患 Guillain-Barré症候群2019

    • Author(s)
      大石 真莉子、古賀 道明、神田 隆
    • Journal Title

      臨床検査

      Volume: 63 Issue: 4 Pages: 394-395

    • DOI

      10.11477/mf.1542201940

    • ISSN
      0485-1420, 1882-1367
    • Year and Date
      2019-04-15
    • Related Report
      2019 Research-status Report
  • [Journal Article] Antecedent infections in Fisher syndrome: sources of variation in clinical characteristics.2019

    • Author(s)
      Koga M, Kishi M, Fukusako T, Ikuta N, Kato M, Kanda T
    • Journal Title

      Journal of Neurology

      Volume: 266 Issue: 7 Pages: 1655-1662

    • DOI

      10.1007/s00415-019-09308-x

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of severe acute flaccid myelitis requiring continuous mechanical ventilation2019

    • Author(s)
      Matsuo Kinya、Koga Michiaki、Shiraishi Masahiro、Hasegawa Masanari、Kanda Takashi、Fukusako Toshihiro
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 59 Issue: 9 Pages: 579-583

    • DOI

      10.5692/clinicalneurol.cn-001319

    • NAID

      130007711647

    • ISSN
      0009-918X, 1882-0654
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] ギラン・バレー症候群と血液神経関門の破綻2019

    • Author(s)
      清水崇文 古賀道明 神田 隆
    • Journal Title

      Peripheral Nerve末梢神経

      Volume: 30 Pages: 36-41

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 腓腹神経ときほぐし標本を用いた傍絞輪部間距離の検討2019

    • Author(s)
      佐藤亮太 古賀道明 尾本雅俊 神田 隆
    • Journal Title

      Peripheral Nerve末梢神経

      Volume: 30 Pages: 85-89

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 腫瘍による圧迫/浸潤による神経障害2019

    • Author(s)
      藤澤美和子 古賀道明 神田 隆
    • Journal Title

      Clinical Neuroscience

      Volume: 37 Pages: 1370-1372

    • Related Report
      2019 Research-status Report
  • [Journal Article] 増大特集 Antibody Update 2018 慢性炎症性脱髄性多発ニューロパチーの自己抗体2018

    • Author(s)
      古賀道明
    • Journal Title

      BRAIN and NERVE

      Volume: 70 Issue: 4 Pages: 395-403

    • DOI

      10.11477/mf.1416201012

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2018-04-01
    • Related Report
      2018 Research-status Report
  • [Journal Article] Experimental approach in a research of Guillain-Barre syndrome: a range of pathogeneses mediated by molecular mimicry2018

    • Author(s)
      Koga M
    • Journal Title

      Clin Exp Neuroimmunol

      Volume: 9 Issue: 2 Pages: 93-100

    • DOI

      10.1111/cen3.12457

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distal limb weakness phenotype of Guillain-Barre syndrome2018

    • Author(s)
      Koga M, Kishi M, Fukusako T, Kanda T
    • Journal Title

      J Neurol Sci

      Volume: 392 Pages: 83-88

    • DOI

      10.1016/j.jns.2018.07.010

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of Hashimoto’s encephalopathy successfully treated with cyclophosphamide pulse therapy2018

    • Author(s)
      松尾欣哉 古賀道明 本田真也 神田 隆
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 58 Issue: 6 Pages: 390-394

    • DOI

      10.5692/clinicalneurol.cn-001169

    • NAID

      130007411704

    • ISSN
      0009-918X, 1882-0654
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cytomegalovirus myositis complicated with hemophagocytic lymphohistiocytosis, acute renal failure, and colitis2018

    • Author(s)
      松尾欣哉 西原秀昭 古賀道明 尾本雅俊 小笠原淳一 川井元晴 神田 隆
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 58 Issue: 7 Pages: 423-429

    • DOI

      10.5692/clinicalneurol.cn-001119

    • NAID

      130007420129

    • ISSN
      0009-918X, 1882-0654
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 抗MAG抗体陽性脱髄性ニューロパチー2018

    • Author(s)
      古賀道明
    • Journal Title

      Peripheral Nerve末梢神経

      Volume: 29 Pages: 17-23

    • Related Report
      2018 Research-status Report
  • [Journal Article] 糖尿病性ニューロパチー2018

    • Author(s)
      太田怜子 古賀道明 神田 隆
    • Journal Title

      Clinical Neuroscience

      Volume: 36 Pages: 453-455

    • Related Report
      2018 Research-status Report
  • [Journal Article] 診療の秘訣:ギラン・バレー症候群を疑ったら・・・2018

    • Author(s)
      古賀道明
    • Journal Title

      Modern Physician

      Volume: 38 Pages: 602-602

    • Related Report
      2018 Research-status Report
  • [Presentation] 軽症のカンピロバクター腸炎後ギラン・バレー症候群:臨床像と病態2020

    • Author(s)
      古賀道明、清水文崇、川井元晴、神田 隆
    • Organizer
      第61回日本神経学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 自己免疫性脳炎の国内動向:全国調査の結果から2020

    • Author(s)
      古賀道明、大石真莉子、神田 隆
    • Organizer
      第61回日本神経学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 軽症のカンピロバクター腸炎後ギラン・バレー症候群:臨床像と病態2020

    • Author(s)
      古賀道明、清水文崇、川井元晴、神田 隆
    • Organizer
      第31回日本末梢神経学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 軽症のカンピロバクター腸炎後ギラン・バレー症候群:臨床像と病態2020

    • Author(s)
      古賀道明、清水文崇、川井元晴、神田 隆
    • Organizer
      第32回日本神経免疫学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] フィッシャー症候群における臨床像と病態:先行感染が規定している2019

    • Author(s)
      古賀道明、岸 雅彦、福迫俊弘、永田倫之、生田尚美、加藤幹元、川井元晴、神田 隆
    • Organizer
      第60回日本神経学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] フィッシャー症候群における臨床像と病態:先行感染が規定している2019

    • Author(s)
      古賀道明、岸 雅彦、福迫俊弘、生田尚美、加藤幹元、神田 隆
    • Organizer
      第30回日本末梢神経学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] フィッシャー症候群における臨床像と病態:先行感染が規定している2019

    • Author(s)
      古賀道明、岸 雅彦、福迫俊弘、生田尚美、加藤幹元、神田 隆
    • Organizer
      第31回日本神経免疫学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Guillain-Barre候群の臨床亜型2019

    • Author(s)
      古賀道明
    • Organizer
      第31回日本神経免疫学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ギラン・バレー症候群とクラミドフィラ肺炎2018

    • Author(s)
      古賀道明、小笠原 惇一、川井元晴、神田 隆
    • Organizer
      第59回日本神経学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] ギラン・バレー症候群とクラミドフィラ肺炎2018

    • Author(s)
      古賀道明、小笠原 惇一、川井元晴、神田 隆
    • Organizer
      第29回日本末梢神経学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 神経系の自己抗原の研究:リポ多糖2018

    • Author(s)
      古賀道明
    • Organizer
      第30回日本神経免疫学会学術大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] CIDP治療:Cons (IVIg派)2018

    • Author(s)
      古賀道明
    • Organizer
      第39回日本アフェレシス学会学術大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Book] 今日の治療指針 2021年版2021

    • Author(s)
      古賀道明
    • Total Pages
      2192
    • Publisher
      医学書院
    • ISBN
      9784260042833
    • Related Report
      2020 Annual Research Report 2019 Research-status Report
  • [Book] 脳神経疾患最新の治療2021-20232021

    • Author(s)
      古賀道明
    • Total Pages
      380
    • Publisher
      南江堂
    • ISBN
      9784524227853
    • Related Report
      2020 Annual Research Report
  • [Book] 内科学 第12版2021

    • Author(s)
      古賀道明
    • Publisher
      朝倉書店
    • Related Report
      2019 Research-status Report
  • [Book] 脳神経疾患最新の治療 2021-20232021

    • Author(s)
      古賀道明
    • Publisher
      南江堂
    • Related Report
      2019 Research-status Report
  • [Book] 新臨床内科学  第10版2020

    • Author(s)
      古賀道明
    • Total Pages
      2002
    • Publisher
      医学書院
    • ISBN
      9784260038065
    • Related Report
      2020 Annual Research Report
  • [Book] 今日の治療指針 2020年版2020

    • Author(s)
      古賀道明
    • Total Pages
      2192
    • Publisher
      医学書院
    • ISBN
      4260039407
    • Related Report
      2019 Research-status Report
  • [Book] 今日の処方(改訂第6版)2019

    • Author(s)
      古賀道明
    • Total Pages
      904
    • Publisher
      南江堂
    • ISBN
      9784524251193
    • Related Report
      2019 Research-status Report
  • [Book] 今日の治療指針 2019年版 私はこう治療している2019

    • Author(s)
      古賀道明
    • Total Pages
      2160
    • Publisher
      医学書院
    • ISBN
      4260036513
    • Related Report
      2018 Research-status Report
  • [Book] 新・今日の処方 改訂第6版2019

    • Author(s)
      古賀道明
    • Total Pages
      904
    • Publisher
      南江堂
    • ISBN
      4524251197
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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