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Molecular mechanism of serum resistance on Borrelia miyamotoi

Research Project

Project/Area Number 18K07132
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 49050:Bacteriology-related
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

Kawabata Hiroki  国立感染症研究所, 細菌第一部, 室長 (60280765)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords新興回帰熱 / 血清耐性 / 血清感受性 / ボレリア / ビトロネクチン / Borrelia miyamotoi / ボレリアミヤモトイ病 / ダニ媒介性
Outline of Final Research Achievements

We analyzed the serum resistance mechanism of Borrelia miyamotoi, an emerging relapsing fever pathogen. We found that the bom1093 and bom1515 genes encoded on B. miyamotoi episomal chromosome are deeply involved in the serum resistance mechanism of B. miyamotoi, and that their function is to bind to vitronectin in serum. These factors could negatively regulate the complement terminal pathway, thereby circumventing the bactericidal mechanism.

Academic Significance and Societal Importance of the Research Achievements

新興回帰熱起因菌であるBorrelia miyamotoiの病原メカニズムはほとんど解明されていない。本研究は新興回帰熱患者が高度の菌血症を呈することから、病原体B. miyamotoiは、ヒト自然免疫機構の一つである補体系への抵抗性を示すと考えられた。この作業仮説を元に、本研究ではB.miyamotoiの新規病原因子BOM1093が血清中のビトロネクチンへ結合することで補体系のTerminal pathwayを負に制御することを明らかにした。これらの発見は、新興回帰熱の病態を理解する上で有意義な発見となった。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (7 results)

All 2021 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results)

  • [Int'l Joint Research] Washington State University(米国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] College of Hetao(中国)

    • Related Report
      2020 Research-status Report
  • [Journal Article] Vitronectin binding protein, BOM1093, confers serum resistance on Borrelia miyamotoi2021

    • Author(s)
      Sato Kozue, Kumagai Yumi, Sekizuka Tsuyoshi, Kuroda Makoto, Hayashi Tetsuya, Takano Ai, Gaowa, Taylor Kyle R., Ohnishi Makoto, Kawabata Hiroki
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 5462-5462

    • DOI

      10.1038/s41598-021-85069-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] ボレリアの新規病原性評価ツールによる血清耐性機能の解析.2019

    • Author(s)
      佐藤梢,熊谷由美,関塚剛史,黒田誠,林哲也,高野愛,大西真,川端寛樹.
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] ボレリア属細菌の新規病原性評価ツールの開発とその応用.2018

    • Author(s)
      佐藤梢,熊谷由美,林哲也,高野愛,大西真,川端寛樹.
    • Organizer
      第161回日本獣医学会学術集会.
    • Related Report
      2018 Research-status Report
  • [Presentation] ボレリア属細菌の新規病原性評価ツールの開発とその応用.2018

    • Author(s)
      佐藤梢,熊谷由美,林哲也,高野愛,大西真,川端寛樹.
    • Organizer
      第26回ダニと疾患のインターフェイスに関するセミナー.
    • Related Report
      2018 Research-status Report
  • [Presentation] ボレリア属細菌の新規病原性評価ツールの開発とその応用.2018

    • Author(s)
      佐藤梢,熊谷由美,林哲也,高野愛,大西真,川端寛樹.
    • Organizer
      第70回日本衛生動物学会大会.
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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