| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The goal of this study was to elucidate the involvement of the auditory cortex in tinnitus in detail and to develop a novel tinnitus suppression method based on the brain stimulation methodology. Here, we adopted a flavin protein fluorescence imaging and multi-electrode array to record and analyze how the activity of neurons in each subfield and layer of the mouse auditory cortex changes related tinnitus. We revealed the excitatory-inhibitory balance were changed according to the condition of tinnitus. In addition, we developed new electrical and magnetic brain stimulation methods, and elicited neuronal responses which is almost identical to the auditory responses. We also showed such kind of brain stimulation elicit plastic changes in the auditory responses. These results provide the basic technology necessary for the development of a new tinnitus suppression method.
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