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Establishment of examinational basis for pathological trans-differentiation of adipocytes through soluble LR11

Research Project

Project/Area Number 18K07428
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52010:General internal medicine-related
Research InstitutionToho University

Principal Investigator

Jiang Meizi  東邦大学, 医学部, 非常勤研究生 (00624066)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsフェノタイプ変換 / LDLレセプタースーパーファミリー / LR11 / 脂肪細胞 / ディファレンシエーション / 褐色脂肪 / ベージュ脂肪 / 病的フェノタイプ変換 / ブラウニング / 可溶性 / 検査医学 / 検査学 / 可溶性LR11 / 肥満 / 糖尿病
Outline of Final Research Achievements

The aim of this study was to clarify the role of LR11, an LDL receptor super-family member, on the browning phenotype transition of adipocytes. The cell-biological study using 2D-cultured brown adipocytes and 3D-cultured beige adipocytes suggested that LR11 is involved in the trans-differentiation mechanism among the white, brown and beige phenotypes of the cultured adipocytes. The human sample studies indicated that circulating soluble LR11 levels are increased in diseases with advanced atherosclerosis. LR11 is expected to be an examination marker for atherosclerosis in association with the disturbed regulation of trans-differentiation in adipocytes.

Academic Significance and Societal Importance of the Research Achievements

主な学術的意義は、これまで細胞培養系では生体で見られる形態と機能を鑑別することが難しかった白色細胞と褐色・ベージュ脂肪細胞の特徴を表現する三次元培養解析系を確立したこと、さらに、それを用いて脂肪細胞のブラウニングフェノタイプ機構におけるLDLレセプタースーパーファミリーLR11の関与を明らかにしたことである。社会的意義は、血中可溶性LR11濃度が動脈硬化で高値を示すという検査学的病態基盤を同定したことである。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (13 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (5 results) Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Int'l Joint Research] 延辺大学付属病院(中国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] 延辺大学附属病院(中国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] 延辺大学附属病院(中国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] 延辺大学(中国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] ケンブリッジ大学(英国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Soluble LR11 as a Novel Biomarker in Acute Kawasaki Disease2022

    • Author(s)
      Watanabe Kenichi、Suzuki Hiroshi、Jiang Meizi、Tsukano Shinya、Kataoka Satoshi、Ito Sueshi、Sakai Takatsugu、Hirokawa Toru、Saitoh Akihiko、Bujo Hideaki
    • Journal Title

      Circulation Journal

      Volume: 86 Issue: 6 Pages: 977-983

    • DOI

      10.1253/circj.CJ-20-1271

    • NAID

      130008088823

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2022-05-25
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LR11, an LDL Receptor Gene Superfamily Member, Represses the Norepinephrine-Induced Expression of Uncoupling Protein 1 in Primary Cultured Beige Adipocytes2021

    • Author(s)
      Shoko Nakamura, Meizi Jiang, Rena Oka, Takashi Yamaguchi, Nobuyuki Hiruta, Hiroyuki Ebinuma, Wolfgang J Schneider, Ichiro Tatsuno and Hideaki Bujo
    • Journal Title

      Toho Journal of Medicine

      Volume: 7 Issue: 1 Pages: 48-56

    • DOI

      10.14994/tohojmed.2020-019

    • NAID

      120006976149

    • ISSN
      21891990
    • URL

      https://toho.repo.nii.ac.jp/records/2002962

    • Year and Date
      2021-03-01
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Levels of circulating soluble LR11, a regulator of smooth muscle cell migration, are highly associated with atherosclerotic plaques in patients with carotid artery stenosis2019

    • Author(s)
      Harada M, Jiang M, Terai K, Ebinuma H, Hiruta N, Schneider WJ, Sugo N, Nagao T, Bujo H
    • Journal Title

      Clin Chim Acta

      Volume: 490 Pages: 69-76

    • DOI

      10.1016/j.cca.2018.12.005

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Susceptibilities of epicardial and subcutaneous fat tissue for browning-gene expression and diet-induced volume reduction are different2018

    • Author(s)
      Mikamo H, Jiang M, Noro M, Suzuki Y, Hiruta N, Unoki-Kubota H, Schneider WJ, Bujo H.
    • Journal Title

      Mol Med Rep

      Volume: 17 Pages: 6542-6550

    • DOI

      10.3892/mmr.2018.8690

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 疾患マーカーとしての可溶性リポ蛋白受容体-脂肪細胞バイオマーカ ーの可能性-2020

    • Author(s)
      姜 美子, 武城英明
    • Organizer
      第52回日本動脈硬化学会総会・学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] The LDL-receptor relative LR11 is an autonomous regulator of white-to-beige trans-differentiation in polymer-scaffold 3D-cultured adipocytes.2019

    • Author(s)
      Meizi Jiang, Tatsuro Kanaki, Akiteru Hayashi, Hiroyuki Ebinuma, Wolfgang J. Schneider, Hideaki Bujo
    • Organizer
      American Heart Association(AHA)Scientific Sessions 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Expression of LR11/SorLA, a thermogenesis suppressor, is regulated in adipogenesis of cultured adipocytes2018

    • Author(s)
      Jiang M, Ebinuma H, Murano T, Bujo H
    • Organizer
      25th European Congress on Obesity
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ベージュ脂肪は高脂肪摂取マウスの脂質異常を抑制する―脂肪の質を変える食事生活指導の可能性―2018

    • Author(s)
      姜 美子, Antonio Vidal-Puig, Monique T. Mulder, Wolfgang J.Schneider, 武城英明
    • Organizer
      第50回日本動脈硬化学会総会・学術集会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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