| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Neutrophil extracellular traps (NETs) formation is a biological defense mechanism in which neutrophil chromatin changes into a meshwork to capture pathogenic microorganisms. In this study, we focused on the fact that NETs stimulate platelets to induce thrombosis, and aimed to elucidate the mechanism of NETs formation and to identify the NETs components that activate platelets.
Using a knockout neutrophil model, we analyzed the intracellular chemical reactions that occur during NETs formation and found that regulation of the neutrophil cytoskeleton is essential for NETs formation. Furthermore, we are investigating two proteins that are abundant in neutrophils as candidate molecules for NETs-derived platelet activation.
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