| Project/Area Number |
18K07622
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
Iwano Hiroyuki 北海道大学, 医学研究院, 客員研究員 (50622354)
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| Co-Investigator(Kenkyū-buntansha) |
横田 卓 北海道大学, 大学病院, 特任講師 (90374321)
納谷 昌直 北海道大学, 大学病院, 講師 (20455637)
安斉 俊久 北海道大学, 医学研究院, 教授 (60232089)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 心不全 / 運動負荷試験 / 心エコー図検査 / 運動負荷 / 慢性心不全 / 運動耐容能 / 運動負荷心エコー検査 |
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| Outline of Final Research Achievements |
Impaired exercise tolerance is a major symptom of heart failure, and heart failure with preserved left ventricular ejection fraction (HFpEF) has a phenotype with no apparent organic abnormalities in the left ventricle. Because the determinants of tolerance in this etiology are not clear, the mechanism of decreased exercise tolerance in this pathological condition was investigated using exercise echocardiography and cardiac MRI.
Cardiopulmonary exercise testing, exercise echocardiography, and contrasted-enhanced cardiac MRI were performed in 49 HFpEF patients without left ventricular hypertrophy, and the determinants of exercise tolerance were examined. As a result, exercise-induced pulmonary hypertension and impaired right ventricular-pulmonary artery coupling, rather than LV diastolic dysfunction, were found to be associated with exercise tolerance.
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| Academic Significance and Societal Importance of the Research Achievements |
左室肥大のないHFpEFにおける運動耐容能低下の意義を明らかにできたことで、発症早期あるいは直前のHFpEFにおける治療ターゲットを提示することができたものと考えられる。
また、心臓MRIにおける心筋線維化指標が、実際の左室拡張障害と関連しなかった原因は、今後さらなる検討により明らかにされることが期待される。
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