| Project/Area Number |
18K07659
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Research Institute, Shiga Medical Center |
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Principal Investigator |
Okuyama Chio 滋賀県立総合病院(研究所), 画像研究部門, 専門研究員 (40347464)
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| Co-Investigator(Kenkyū-buntansha) |
加川 信也 滋賀県立総合病院(研究所), 画像研究部門, 主任研究員 (10393191)
東 達也 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, 部長(定常) (50324629)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 慢性歯周炎 / アミロイド / FPYBF-2 / PET / 歯周炎菌 / 認知機能正常 / F-18 FPYBF2 / 頭部 / 脳内アミロイドβ / 慢性炎症 / 歯周炎 / FPYBF2 |
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| Outline of Final Research Achievements |
We evaluated the correlation between periodontitis and cerebral amyloid tracer uptake in 49 subjects with normal cognitive function, who were classified based on the dental condition into 4 groups: normal (n=9), gingivitis (n=14), moderate (n=12), and severe periodontitis (n=14). Dental examinations and amyloid PET using 18F-FPYBF-2 were performed. Among these groups, no significant differences were seen in the age, MMSE score, or PET results. Periodontitis bacteria: Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Actinobacillus actinomycetemcomitans were measured from periodontal pocket specimens. PET showed no visually positive cases except for one case with focal accumulation in the right occipital lobe. Quantitative evaluation showed no significant difference between groups or the existence of each bacterium. In subjects with normal cognitive function, no significant relationship between periodontitis and amyloid deposition was observed.
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| Academic Significance and Societal Importance of the Research Achievements |
これまでのげっ歯類を用いた研究にて、歯周炎菌の存在が認知症の原因となる脳内アミロイドの蓄積と関連するとの報告が認められていたが、認知機能正常の75歳未満の被験者を対象に、歯肉の健康状態・歯周炎菌の有無と、アルツハイマー病の基本病理である脳内アミロイドの分布を調べたヒトを対象とする今回の検討において、歯周炎菌の存在や歯周炎の罹患が直接的にアミロイドの蓄積をもたらすという結果は見いだせなかった。
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