Compressed Sensing for Brain and Neck MR Imaging

• Project/Area Number: 18K07711
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kyoto University
• Principal Investigator: Fushimi Yasutaka 京都大学, 医学研究科, 講師 (90639014)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 圧縮センシング / MRI / 脳 / MRA / 造影剤 / 頸動脈 / 脳血管 / アーティファクト

Outline of Final Research Achievements

Compressive sensing is a novel mathematical method to find a solution from sparse sampling data. In this study, we focused on wide-coverage MR imaging, artifact suppression, vessel wall evaluation, and contrast agent reduction by using compressed sensing MRI. Clinical application of compressed sensing MRI was investigated, and the benefits of compressed sensing MRI was demonstrated.

Academic Significance and Societal Importance of the Research Achievements

圧縮センシングMRIの臨床応用により、本来なら撮影時間のかかる広範囲撮影を比較的短時間で撮影することが可能になり、繰り返し画像再構成によるアーチファクト抑制も簡便に行うことが可能となった。圧縮センシングMRIの臨床応用の妥当性を証明できた。MRIの画質安定に貢献したことは学術的に意義があると考えられる。血管壁評価においては、血管壁と内腔のコントラストの向上、造影剤減量したMR撮影を可能にすることで造影剤コストや患者負担の軽減に繋がる可能性があり、社会的に意義があると考えられる。

Research Products

• [Journal Article] Quantitative and qualitative evaluation of sequential PET/MRI using a newly developed mobile PET system for brain imaging. (2021)
  • Author(s): Suzuki M, Fushimi Y, Okada T, Hinoda T, Nakamoto R, Arakawa Y, Sawamoto N, Togashi K, Nakamoto Y.
  • Journal Title: Jpn J Radiol. Volume: 印刷中 Issue: 7 Pages: 669-680
  • DOI: 10.1007/s11604-021-01105-9
  • NAID: 210000186070
  • Peer Reviewed
• [Journal Article] Neuromelanin-Sensitive Magnetic Resonance Imaging Using DANTE Pulse. (2021)
  • Author(s): Oshima S, Fushimi Y, Okada T, Nakajima S, Yokota Y, Shima A, Grinstead J, Ahn S, Sawamoto N, Takahashi R, Nakamoto Y.
  • Journal Title: Mov Disord. Volume: 36 Issue: 4 Pages: 874-882
  • DOI: 10.1002/mds.28417
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Deep Learning-based Noise Reduction for Fast Volume Diffusion Tensor Imaging: Assessing the Noise Reduction Effect and Reliability of Diffusion Metrics (2021)
  • Author(s): Sagawa Hajime、Fushimi Yasutaka、Nakajima Satoshi、Fujimoto Koji、Miyake Kanae Kawai、Numamoto Hitomi、Koizumi Koji、Nambu Masahito、Kataoka Hiroharu、Nakamoto Yuji、Saga Tsuneo
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 20 Issue: 4 Pages: 450-456
  • DOI: 10.2463/mrms.tn.2020-0061
  • NAID: 130008123654
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Two-Minute Quantitative Susceptibility Mapping From Three-Dimensional Echo-Planar Imaging: Accuracy, Reliability, and Detection Performance in Patients With Cerebral Microbleeds. (2021)
  • Author(s): Wicaksono KP, Fushimi Y, Nakajima S, Yokota Y, Oshima S, Otani S, Sakurama A, Shima A, Sawamoto N, Okada T, Nakamoto Y.
  • Journal Title: Invest Radiol. Volume: 56 Issue: 2 Pages: 69-77
  • DOI: 10.1097/rli.0000000000000708
  • NAID: 120006958079
  • Peer Reviewed
• [Journal Article] Evaluation of cerebral arteriovenous shunts: a comparison of parallel imaging time-of-flight magnetic resonance angiography (TOF-MRA) and compressed sensing TOF-MRA to digital subtraction angiography (2020)
  • Author(s): Sakata Akihiko、Fushimi Yasutaka、Okada Tomohisa、Nakajima Satoshi、Hinoda Takuya、Speier Peter、Schmidt Michaela、Forman Christoph、Yoshida Kazumichi、Kataoka Hiroharu、Miyamoto Susumu、Nakamoto Yuji
  • Journal Title: Neuroradiology Volume: - Issue: 6 Pages: 879-887
  • DOI: 10.1007/s00234-020-02581-y
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cerebral Infarction With Increased Uptake on 123I-FP-CIT SPECT (2020)
  • Author(s): Nakajima Satoshi、Fushimi Yasutaka、Kawashima Hirotsugu、Murai Toshiya、Nakamoto Yuji
  • Journal Title: Clinical Nuclear Medicine Volume: 46 Issue: 4 Pages: e193-e194
  • DOI: 10.1097/rlu.0000000000003366
  • Peer Reviewed
• [Journal Article] Signal Intensity and Volume of Pituitary and Thyroid Glands in Preterm and Term Infants (2020)
  • Author(s): Otani Sayo、Fushimi Yasutaka、Iwanaga Kogoro、Tomotaki Seiichi、Yokota Yusuke、Oshima Sonoko、Sakurama Azusa、Wicaksono Krishna Pandu、Hinoda Takuya、Sakata Akihiko、Nakajima Satoshi、Okada Tomohisa、Takita Junko、Kawai Masahiko、Togashi Kaori
  • Journal Title: Journal of Magnetic Resonance Imaging Volume: 53 Issue: 4 Pages: 1151-1161
  • DOI: 10.1002/jmri.27395
  • NAID: 120007026445
  • Peer Reviewed / Open Access
• [Journal Article] Brain MRI with Quantitative Susceptibility Mapping: Relationship to CT Attenuation Values (2020)
  • Author(s): Oshima S, Fushimi Y, Okada T, Takakura K, Liu C, Yokota Y, Arakawa Y, Sawamoto N, Miyamoto S, Togashi K
  • Journal Title: Radiology Volume: 294 Issue: 3 Pages: 600-609
  • DOI: 10.1148/radiol.2019182934
  • NAID: 120007026444
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Acceleration of 2D-MR fingerprinting by reducing the number of echoes with increased in-plane resolution: a volunteer study (2020)
  • Author(s): Yokota Y, Okada T, Fushimi Y, Yamamoto A, Nakajima S, Fujimoto K, Oshima S, Koerzdoerfer G, Nittka M, Pfeuffer J, Togashi K
  • Journal Title: MAGMA Volume: － Issue: 6 Pages: 783-791
  • DOI: 10.1007/s10334-020-00842-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Editorial for “Quantitative Susceptibility Mapping for Characterization of Intraplaque Hemorrhage and Calcification in Carotid Atherosclerotic Disease” (2020)
  • Author(s): Fushimi Yasutaka, Nakajima Satoshi
  • Journal Title: Journal of Magnetic Resonance Imaging Volume: ー Issue: 2 Pages: 542-543
  • DOI: 10.1002/jmri.27089
  • NAID: 120006878495
  • Peer Reviewed
• [Journal Article] Evaluation of image quality of pituitary dynamic contrast‐enhanced MRI using time‐resolved angiography with interleaved stochastic trajectories (TWIST) and iterative reconstruction TWIST (IT‐TWIST) (2020)
  • Author(s): Yokota Y, Fushimi Y, Okada T, Fujimoto K, Oshima S, Nakajima S, Fujii T, Tanji M, Inagaki N, Miyamoto S, Togashi K
  • Journal Title: Journal of Magnetic Resonance Imaging Volume: 51 Issue: 5 Pages: 1497-1506
  • DOI: 10.1002/jmri.26962
  • NAID: 120006840153
  • Peer Reviewed
• [Journal Article] Identification of the Bleeding Point in Hemorrhagic Moyamoya Disease Using Fusion Images of Susceptibility-Weighted Imaging and Time-of-Flight MRA (2019)
  • Author(s): Miyakoshi A.、Funaki T.、Fushimi Y.、Kikuchi T.、Kataoka H.、Yoshida K.、Mineharu Y.、Takahashi J.C.、Miyamoto S.
  • Journal Title: American Journal of Neuroradiology Volume: 40 Pages: 1674-1680
  • DOI: 10.3174/ajnr.a6207
  • Peer Reviewed
• [Journal Article] Restoration of periventricular vasculature after direct bypass for moyamoya disease: intra-individual comparison (2019)
  • Author(s): Miyakoshi Akinori、Funaki Takeshi、Takahashi Jun C、Takagi Yasushi、Kikuchi Takayuki、Yoshida Kazumichi、Kataoka Hiroharu、Mineharu Yohei、Okawa Masakazu、Yamao Yukihiro、Fushimi Yasutaka、Okada Tomohisa、Togashi Kaori、Miyamoto Susumu
  • Journal Title: Acta Neurochirurgica Volume: Epub aheda of print Issue: 5 Pages: 947-954
  • DOI: 10.1007/s00701-019-03866-9
  • Peer Reviewed
• [Journal Article] Visualization of carotid vessel wall and atherosclerotic plaque: T1-SPACE vs. compressed sensing T1-SPACE. (2018)
  • Author(s): Okuchi S, Fushimi Y, Okada T, Yamamoto A, Okada T, Kikuchi T, Yoshida K, Miyamoto S, Togashi K
  • Journal Title: Eur Radiol Volume: ePub Issue: 8 Pages: 4114-4122
  • DOI: 10.1007/s00330-018-5862-8
  • Peer Reviewed
• [Presentation] Compress sensing TOF-MRAを用いた頭頚部AV shuntの評価。 (2021)
  • Author(s): 坂田昭彦、伏見育崇、中島諭、日野田卓也、大嶋園子、大谷紗代、櫻間梓、Krishna Pandu Wicaksono、田川弘、汪洋、中本裕士。
  • Organizer: 第50回日本神経放射線学会
• [Presentation] Reliability Study of Quantitative Susceptibility Mapping from Three-Dimensional Echo-Planar Imaging with 2 Minutes Scan Time. (2020)
  • Author(s): Krishna Pandu Wicaksono, Yasutaka Fushimi, Tomohisa Okada, Satoshi Nakajima, Sonoko Oshima, Yusuke Yokota, Azusa Sakurama, Sayo Otani, and Kaori Togashi.
  • Organizer: ISMRM 28th 2020 ISMRM & SMRT Virtual Conference & Exhibition.
  • Int'l Joint Research
• [Presentation] Application of Deep Learning Reconstruction to Compressed-sensing Thin-slice Fat-suppressed T2-weighted Imaging of the Orbit. (2020)
  • Author(s): Satoshi Nakajima, Yasutaka Fushimi, Yusuke Yokota, Sonoko Oshima, Sayo Otani, Azusa Sakurama, Krishna Pandu Wicaksono, Yuichiro Sano, Ryo Matsuda, Masahito Nambu, Koji Fujimoto, Hitomi Numamoto, Kanae Kawai Miyake, Tsuneo Saga, and Kaori Togashi.
  • Organizer: ISMRM 28th 2020 ISMRM & SMRT Virtual Conference & Exhibition.
  • Int'l Joint Research
• [Presentation] Quiet Diffusion-weighted Imaging in Pediatric Patients with Moyamoya Disease. (2020)
  • Author(s): Satoshi Nakajima, Yasutaka Fushimi, Tomohisa Okada, Gosuke Okubo, Yusuke Yokota, Sonoko Oshima, Sayo Otani, Azusa Sakurama, Krishna Pandu Wicaksono, and Kaori Togashi.
  • Organizer: ISMRM 28th 2020 ISMRM & SMRT Virtual Conference & Exhibition.
  • Int'l Joint Research
• [Presentation] Evaluation of the Substantia Nigra and Locus Coeruleus by Neuromelanin-Sensitive MR Imaging with Deep Learning Based Noise Reduction (2020)
  • Author(s): Sonoko Oshima, Yasutaka Fushimi, Satoshi Nakajima, Yusuke Yokota, Sayo Otani, Azusa Sakurama, Krishna Pandu Wicaksono, Yuichiro Sano, Ryo Matsuda, Masahito Nambu, Koji Fujimoto, Hitomi Numamoto, Kanae Kawai Miyake, Tsuneo Saga, and Kaori Togashi.
  • Organizer: ISMRM 28th 2020 ISMRM & SMRT Virtual Conference & Exhibition.
  • Int'l Joint Research
• [Presentation] Clinical Application of Six-fold Accelerated Submillimeter Whole Brain 3D T2-weighted Imaging with Deep Learning Reconstruction. (2020)
  • Author(s): Sayo Otani, Yasutaka Fushimi, Satoshi Nakajima, Yusuke Yokota, Sonoko Oshima, Azusa Sakurama, Krishna Pandu Wicaksono, Yuichiro Sano, Ryo Matusda, Masahito Nambu, Koji Fujimoto, Hitomi Numamoto, Kanae Kawai Miyake, Tsuneo Saga, and Kaori Togashi.
  • Organizer: ISMRM 28th 2020 ISMRM & SMRT Virtual Conference & Exhibition.
  • Int'l Joint Research
• [Presentation] The Signal Intensity of Anterior and Posterior Lobe of Pituitary and Thyroid Gland in Preterm and Term Infants. (2020)
  • Author(s): Sayo Otani, Yasutaka Fushimi, Satoshi Nakajima, Yusuke Yokota, Sonoko Oshima, Azusa Sakurama, Krishna Pandu Wicaksono, Tomohisa Okada, and Kaori Togashi.
  • Organizer: ISMRM 28th 2020 ISMRM & SMRT Virtual Conference & Exhibition.
  • Int'l Joint Research
• [Presentation] Comparison between MPRAGE GRAPPA 2×1 with MPRAGE Wave-CAIPI 3×3. (2020)
  • Author(s): Azusa Sakurama, Yasutaka Fushimi, Satoshi Nakajima, Yusuke Yokota, Sonoko Oshima, Sayo Otani, Krishna Pandu Wicaksono, Tomohisa Okada, Wei Liu, and Kaori Togashi.
  • Organizer: ISMRM 28th 2020 ISMRM & SMRT Virtual Conference & Exhibition.
  • Int'l Joint Research
• [Presentation] Toward the hemodynamic analysis of Moyamoya disease using ultra-fast DCE-MRI by GRASP. (2020)
  • Author(s): Koji Fujimoto, Yasutaka Fushimi, Takeshi Funaki, Satoshi Nakajima, Yusuke Yokota, Sonoko Oshima, Sayo Otani, Azusa Sakurama, Krishna Wicaksono Pandu, Tomohisa Okada, and Kaori Togashi.
  • Organizer: ISMRM 28th 2020 ISMRM & SMRT Virtual Conference & Exhibition.
  • Int'l Joint Research
• [Presentation] 3D EPIとGRE撮影から作成した定量的磁化率マッピングに関する基礎的検討 (2020)
  • Author(s): 伏見育崇、Krishna Pandu Wicaksono、岡田知久、中島諭、日野田卓也、大嶋園子、大谷紗代、櫻間梓、汪洋、田川弘、中本裕士
  • Organizer: 第48回日本磁気共鳴医学会大会
• [Presentation] Quantitative susceptibility mapping: clinical application for pediatric diseases. (2019)
  • Author(s): Sonoko Oshima, Yasutaka Fushimi, Tomohisa Okada, Akira Yamamoto, Satoshi Nakajima, Yusuke Yokota, Sayo Otani, Azusa Ota, Krishna Pandu Wicaksono, and Kaori Togashi
  • Organizer: RSNA 2019
  • Int'l Joint Research
• [Presentation] Compressed Sensing MR Angiography from Simulation Research to Clinical Practices. (2019)
  • Author(s): Sayo Otani, Yasutaka Fushimi, Koji Fujimoto, Takayuki Yamamoto, Azusa Ota, Krishna Pandu Wicaksono, Sonoko Oshima, Yusuke Yokota, Satoshi Nakajima, Akihiko Sakata, Akira Yamamoto, Peter Speier, Christoph Forman, Michaela Schmidt, Tomohisa Okada, and Kaori Togashi.
  • Organizer: RSNA 2019
  • Int'l Joint Research
• [Presentation] The Effect of delay alternating with nutation for tailored excitation (DANTE) pulse on cerebrospinal fluid, brain parenchyma, arteries and veins. (2019)
  • Author(s): Yasutaka Fushimi, Satoshi Nakajima, Sonoko Oshima, Yusuke Yokota, Sayo Otani, Azusa Ota, John Grinstead, Sinyeob Ahn, Tomohisa Okada, and Kaori Togashi.
  • Organizer: 13th Annual Meeting of the American Society of Functional Neuroradiology
  • Int'l Joint Research
• [Presentation] Grading of Glioma: Comparison between18F-FMISO-PET, Apparent Diffusion Coefficient and Gadolinium Enhancement. (2019)
  • Author(s): Yasutaka Fushimi, Yoshiki Arakawa, Yoichi Shimizu, Kohei Sano, Tomohisa Okada, Sonoko Oshima, Takuya Hinoda, Satoshi Nakajima, Takayoshi Ishimori, Yuji Nakamoto and Kaori Togashi
  • Organizer: SNMMI 2019
  • Int'l Joint Research
• [Presentation] 3D T1-weighted Images with Scan Time of Less than 2 Minutes by Using Wave-CAIPI (2019)
  • Author(s): Yasutaka Fushimi, Tomohisa Okada, Sonoko Oshima, Yusuke Yokota, Hikaru Fukutomi, Gosuke Okubo, Satoshi Nakajima, Akira Yamamoto, Wei Liu, Sinyeob Ahn, Thomas Beck, and Kaori Togashi.
  • Organizer: ISMRM 2019
  • Int'l Joint Research
• [Presentation] Comparison study of QSM calculated from different image sequences. (2019)
  • Author(s): Yasutaka Fushimi, Tomohisa Okada, Sonoko Oshima, Yusuke Yokota, Hikaru Fukutomi, Gosuke Okubo, Satoshi Nakajima, Akira Yamamoto, Sunil Patil, Pascal Sati, and Kaori Togashi.
  • Organizer: ISMRM 2019
  • Int'l Joint Research
• [Presentation] Correlation between CT and QSM in the brain. (2019)
  • Author(s): Sonoko Oshima, Yasutaka Fushimi, Tomohisa Okada, Akira Yamamoto, Satoshi Nakajima, Gosuke Okubo, Hikaru Fukutomi, Yusuke Yokota, and Kaori Togashi. Co
  • Organizer: ISMRM 2019
  • Int'l Joint Research
• [Presentation] Visualization of the Substantia Nigra Pars Compacta: comparison between DANTE T1-SPACE and T1-SPACE. (2019)
  • Author(s): Sonoko Oshima, Yasutaka Fushimi, Tomohisa Okada, Akira Yamamoto, Satoshi Nakajima, Gosuke Okubo, Hikaru Fukutomi, Yusuke Yokota, John Grinstead, Sinyeob Ahn, and Kaori Togashi.
  • Organizer: ISMRM 2019
  • Int'l Joint Research
• [Presentation] Evaluation of image quality of pituitary dynamic contrast-enhanced MRI using TWIST and IT-TWIST. (2019)
  • Author(s): Yusuke Yokota, Yasutaka Fushimi, Tomohisa Okada, Hikaru Fukutomi, Akira Yamamoto, Satoshi Nakajima, Gosuke Okubo, Sonoko Oshima, Koji Fujimoto, and Kaori Togashi.
  • Organizer: ISMRM 2019
  • Int'l Joint Research