Amide proton transfer (APT) imaging of breast tumors

• Project/Area Number: 18K07717
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kyushu University
• Principal Investigator: Kamitani Takeshi 九州大学, 大学病院, 講師 (20419534)
• Co-Investigator(Kenkyū-buntansha): 鷺山 幸二 九州大学, 大学病院, 助教 (20755243) ; 山崎 誘三 九州大学, 大学病院, 助教 (00643347) ; 松浦 由布子 九州大学, 大学病院, 医員 (40825345) ; 日野 卓也 九州大学, 大学病院, 医員 (10807100) ; 筒井 聡一郎 九州大学, 大学病院, 医員 (50825346) ; 藪内 英剛 九州大学, 医学研究院, 教授 (70380623) ; 本田 浩 九州大学, 大学病院, 教授 (90145433)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 乳癌 / MRI / CEST / APT / 乳腺

Outline of Final Research Achievements

We assessed the usefulness of APT imaging to predict the biological status of breast cancers. The triple-negative (TN) cancers showed significantly higher APT signal intensity (SI) than the luminal type cancers and HER2 cancers. APT SI had weakly positive correlation with the Ki-67 labeling index. The mean APT SIs were significantly higher for high-Ki-67 (>30%) than low-Ki-67 (≦30%) cancers. There was no significant difference in the APT SIs among nuclear grades.
These results were presented at European Congress of Radiology 2022 and a paper was published in Clinical Imaging.

Academic Significance and Societal Importance of the Research Achievements

乳癌診療においては、組織型のみならず、ホルモンレセプターやHER2発現の有無、Ki-67などの生物学的所見が治療方針に大きな影響を与える。これらの診断には組織診が不可欠であるが、病変の一部のみでの評価となる生検材料と手術標本での結果が一致しないこともあり、侵襲度が低く病変全体を評価することのできる画像で予測をつけることは臨床的に有用である。本研究では内因性Chemical Exchange Saturation Transfer（CEST）法の一種であるAmide Proton Transfer (APT) イメージングにて計測したAPT信号が生物学的所見の予測に有用であることを示した。

Research Products

• [Journal Article] Amide proton transfer (APT) imaging of breast cancers and its correlation with biological status (2023)
  • Author(s): Kamitani Takeshi、Sagiyama Koji、Yamasaki Yuzo、Hino Takuya、Wada Tatsuhiro、Kubo Makoto、Akiyoshi Sayuri、Yamamoto Hidetaka、Yabuuchi Hidetake、Ishigami Kousei
  • Journal Title: Clinical Imaging Volume: 96 Pages: 38-43
  • DOI: 10.1016/j.clinimag.2023.02.002
  • Peer Reviewed
• [Journal Article] Virtual monochromatic spectral CT imaging in preoperative evaluations for intraductal spread of breast cancer: comparison with conventional CT and MRI (2023)
  • Author(s): Matsuura Yuko、Kamitani Takeshi、Sagiyama Koji、Yamasaki Yuzo、Hino Takuya、Kubo Makoto、Ijichi Hideki、Yamamoto Hidetaka、Yabuuchi Hidetake、Ishigami Kousei
  • Journal Title: Japanese Journal of Radiology Volume: - Issue: 7 Pages: 733-740
  • DOI: 10.1007/s11604-023-01392-4
  • Peer Reviewed
• [Journal Article] Evaluation of MR imaging findings differentiating parotid basal cell adenomas from other parotid tumors (2021)
  • Author(s): Murayama Yuriko、Kamitani Takeshi、Sagiyama Koji、Yamasaki Yuzo、Hida Tomoyuki、Matsuura Yuko、Yasumatsu Ryuji、Yamamoto Hidetaka、Yabuuchi Hidetake、Ishigami Kousei
  • Journal Title: European Journal of Radiology Volume: 144 Pages: 109980-109980
  • DOI: 10.1016/j.ejrad.2021.109980
  • Peer Reviewed
• [Journal Article] Amide proton transfer (APT) imaging of parotid tumors: Differentiation of malignant and benign tumors (2020)
  • Author(s): Kamitani Takeshi、Sagiyama Koji、Togao Osamu、Yamasaki Yuzo、Hida Tomoyuki、Matsuura Yuko、Murayama Yuriko、Yasumatsu Ryuji、Yamamoto Hidetaka、Yabuuchi Hidetake
  • Journal Title: European Journal of Radiology Volume: 129 Pages: 109047-109047
  • DOI: 10.1016/j.ejrad.2020.109047
  • Peer Reviewed
• [Presentation] Amide proton transfer (APT) imaging of breast cancers: correlation with biological statuses (2022)
  • Author(s): Takeshi Kamitani, Koji Sagiyama, Yuzo Yamasaki, Tomoyuki Hida, Yuko Matsuura, Tatsuhiro Wada, Hidetake Yabuuchi, Kousei Ishigami
  • Organizer: European Congress of Radiology (ECR) 2022
  • Int'l Joint Research