Bidirectional signaling mechanism between the intestinal microbiota and brain: Molecular basis of obesity induced by stress.
Project/Area Number |
18K07879
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 52050:Embryonic medicine and pediatrics-related
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Research Institution | Kagawa University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
太田 健一 香川大学, 医学部, 助教 (50403720)
鈴木 辰吾 香川大学, 医学部, 准教授 (50451430)
横山 俊史 神戸大学, 農学研究科, 助教 (10380156)
割田 克彦 鳥取大学, 農学部, 准教授 (40452669)
金西 賢治 香川大学, 医学部, 教授 (10263906)
日下 隆 香川大学, 医学部, 教授 (50274288)
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Project Period (FY) |
2018-04-01 – 2022-03-31
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Project Status |
Completed (Fiscal Year 2021)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 母子分離 / 幼少期ストレス / 腸内細菌叢 / 炎症性サイトカイン / ミクログリア / 脳発達期ストレス / 炎症 / 内側前頭前皮質 / 発達障害 / ストレス曝露 / 脳発達 / サイトカイン / 脳 / 肥満 / ストレス / 生活習慣病 / 代謝調節 / 中枢神経 / 情報伝達 |
Outline of Final Research Achievements |
Numerous studies reported on the effects of early life stress on brain and body development. However, little is known about how it alters the intestinal bacterial flora. The new vistas for understanding the brain-gut interactions related to the gut microbiota provide further insights to understanding the developmental mechanism of brain-gut interactions. In this study, we examined the gut microbiota of a maternal separation model in rats and found changes in composition particularly related to lifestyle-related diseases and inflammation. Furthermore, this animal model showed an increased expression of inflammatory cytokines released by microglia in the brain during early life. These results suggest that early life stress alters an inflammation-prone gut microbiota, which may cause inflammation in the brain.
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Academic Significance and Societal Importance of the Research Achievements |
本研究成果は、幼少期ストレスが腸内細菌叢組成を変化させる事で生活習慣病及び脳内炎症を引き起こしやすい体内環境を生後早期の時点で作り上げてしまう事を示している。腸内細菌叢という観点から幼少期ストレスの影響を捉えようとする研究はまだ少ないが、この理解が進むことで育児放棄・虐待といった幼少期の不遇な養育環境にあった児のその後の発達を改善する手段として療育のみならず腸内細菌叢の改善という観点が産まれる。本研究結果を基盤に、更なる幼少期ストレスによる脳腸相関を原因とした影響が解明する事でそれを回復する機能性食品などの開発にも繋がる期待がある。
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Report
(5 results)
Research Products
(24 results)
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[Journal Article] Repeated maternal separation causes transient reduction in BDNF expression in the medial prefrontal cortex during early brain development, affecting inhibitory neuron development2020
Author(s)
Chiaki Tenkumo, Ken-ichi Ohta, Shingo Suzuki, Katsuhiko Warita, Kanako Irie, Saki Teradaya, Takashi Kusaka, Kenji Kanenishi, Toshiyuki Hata, Takanori Miki
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Journal Title
Heliyon
Volume: 6
Issue: 8
Pages: e04781-e04781
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] COA-Cl induces dopamine release and tyrosine hydroxylase phosphorylation: In vivo reverse microdialysis and in vitro analysis.2019
Author(s)
Jamal M, Tsukamoto I, Takata M, Ito A, Tanaka N, Miki T, Takakura A, Ameno K, Kubota Y, Konishi R, Kinoshita H.
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Journal Title
Brain Res.
Volume: 1706
Pages: 68-74
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Acetaldehyde administration induces salsolinol formation in vivo in the dorsal striatum of Aldh2-knockout and C57BL/6N mice.2018
Author(s)
Ito A, Jamal M, Ameno K, Tanaka N, Takakura A, Kawamoto T, Kitagawa K, Nakayama K, Matsumoto A, Miki T, Kinoshita H.
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Journal Title
Neurosci Lett.
Volume: 685
Pages: 50-54
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Relationship between prolonged neural suppression and cerebral hemodynamic dysfunction during hypothermia in asphyxiated piglets.2018
Author(s)
Jinnai W, Nakamura S, Koyano K, Yamato S, Wakabayashi T, Htun Y, Nakao Y, Iwase T, Nakamura M, Yasuda S, Ueno M, Miki T, Kusaka T
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Journal Title
Brain Dev
Volume: 40
Issue: 8
Pages: 649-661
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 新生仔豚仮死モデルにおける水素ガス吸入療法による脳保護効果について.2019
Author(s)
中村信嗣, Yinmon Htun, 中尾泰浩, 光家努, 太田健一, 小谷野耕佑, 森本絢, 安田真之, 小西行彦, 加藤育子, 近藤園子, 三木崇範, 上野正樹, 日下隆.
Organizer
平成30年度文部科学省新学術領域研究 学術研究支援基盤形成先端モデル動物支援プラットフォーム成果発表会
Related Report
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