Analysis of tumor microimmune environment formed in the presence of liver cancer-induced HBx mutations

• Project/Area Number: 18K07984
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Kindai University
• Principal Investigator: Satoru HAGIWARA 近畿大学, 医学部, 講師 (40460852)
• Co-Investigator(Kenkyū-buntansha): 工藤 正俊 近畿大学, 医学部, 教授 (10298953)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 肝癌惹起性HBx変異 / 腫瘍微小免疫環境

Outline of Final Research Achievements

It was found that the onset of liver cancer was promoted as a result of increased production of active oxygen and activation of the JNK pathway in the presence of the HBx C1485T mutation. In addition, elucidation of the tumor microimmune environment induced in the presence of the HBxC1485T mutation proved that the cell numbers of TAMs and MDSCs were suppressed, which is one of the factors of the antitumor effect.

Academic Significance and Societal Importance of the Research Achievements

肝癌惹起性ウイルス性病原因子の存在下において形成される腫瘍微小免疫環境の解明した。HBxC1485T変異の存在下で形成される腫瘍微小免疫環境の解明を通して、HBV関連肝癌の新規治療標的を同定することができた。