| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
The purpose of the study was to test the question, "Is heart failure a response to cardiac and systemic starvation?" The objective was to test the question, "Is heart failure a cardiac and systemic starvation response? New measurement techniques allowed us to create a database of starvation responses, and we found that fasting induced cardiac dysfunction. The genetic changes showed some common behavior with heart failure models and human heart failure microarrays. Clustering was possible based on analyses including transcriptomes and metabolomes of liver, skeletal muscle, and cardiac muscle. The multilevel integrated analysis suggested that the systems involved in Gap junction and heme synthesis are decreased as part of the mechanism of cardiac dysfunction in this model, and may be a potential therapeutic target.
|
