Establishment of an International Standard Algorithm for Improving Umbilical Cord Blood Transplantation Outcomes through Clinical Data Analysis

• Project/Area Number: 18K08325
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: Kyoto University
• Principal Investigator: Kanda Junya 京都大学, 医学研究科, 助教 (30636311)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 臍帯血移植

Outline of Final Research Achievements

With the aim of establishing an international standard algorithm for improving cord blood transplantation outcomes, we have established a collaborative research platform between the European Society for Bone Marrow Transplantation and Eurocode, a European cord blood research center, and the Japan Society for Hematopoietic Stem Cell Transplantation and the Japanese Data Center for Hematopoietic Cell Transplantation. We analyzed the impact of various background factors on transplantation outcomes in the integrated HSCT data set and identified similarities and differences in factors affecting transplantation outcomes in the two registries. The results were reported in Leukemia (Kanda J, Leukemia 2020). To further explore the reasons for the difference in cord blood transplantation outcomes between Europe and Japan, we have started an analysis of the effect of GVHD on transplantation outcomes.

Academic Significance and Societal Importance of the Research Achievements

同種造血幹細胞移植は難治性白血病に対して根治が期待できる治療法である。臍帯血は、HLA一致ドナーに代わる代替移植ソースとして急速に拡大した。本研究では日欧共同研究基盤を確立し、人種によらない普遍的な予後予測因子を見出すため、成人急性白血病患者を対象とした、日本と欧州ではじめての国際共同研究を行った。そして、日欧で患者背景や治療内容は大きく異なるものの、移植時病期や患者年齢、移植年、臍帯血有核細胞数などが移植成績に与える影響が、極めて類似していることを示した。本研究成果は、日本と欧州の共同研究を加速させるための重要な基礎データであり、本データをもとに、国際共同後方視的研究を計画する予定である。

Research Products

• [Int'l Joint Research] Eurocord(フランス)
• [Int'l Joint Research] ユーロコード(フランス)
• [Journal Article] Effect of graft-versus-host disease on outcomes after pediatric single cord blood transplantation (2020)
  • Author(s): Kanda Junya、on behalf of the JSHCT GVHD Working Group、Umeda Katsutsugu、Kato Koji、Murata Makoto、Sugita Junichi、Adachi Souichi、Koh Katsuyoshi、Noguchi Maiko、Goto Hiroaki、Yoshida Nao、Sato Maho、Koga Yuhki、Hori Tsukasa、Cho Yuko、Ogawa Atsushi、Inoue Masami、Hashii Yoshiko、Atsuta Yoshiko、Teshima Takanori
  • Journal Title: Bone Marrow Transplantation Volume: 55 Issue: 7 Pages: 1430-1437
  • DOI: 10.1038/s41409-020-0853-1
  • Peer Reviewed
• [Journal Article] Hematopoietic Stem Cell Transplantation From a Related Donor with Human Leukocyte Antigen 1-Antigen Mismatch in the Graft-Versus-Host Direction Using Low-dose Anti-thymocyte Globulin (2020)
  • Author(s): Kanda Junya、Ando Toshihiko、Kimura Shun-ichi、Fujiwara Shin-ichiro、Imada Kazunori、Fujisawa Shin、Tachibana Takayoshi、Atsuta Yoshiko、Kanda Yoshinobu
  • Journal Title: Cell Transplantation Volume: 29 Pages: 1-12
  • DOI: 10.1177/0963689720976567
  • Peer Reviewed
• [Journal Article] Effects of Haplotype Matching on Outcomes after Adult Single-Cord Blood Transplantation (2020)
  • Author(s): Kanda Junya、Kawase Takakazu、Tanaka Hidenori、Kojima Hiroto、Morishima Yasuo、Uchida Naoyuki、Nagafuji Koji、Matsuhashi Yoshiko、Ohta Takanori、Onizuka Makoto、Sakura Toru、Takahashi Satoshi、Miyakoshi Shigesaburo、Kobayashi Hikaru、Eto Tetsuya、Tanaka Junji、Ichinohe Tatsuo、Atsuta Yoshiko、Morishima Satoko
  • Journal Title: Biology of Blood and Marrow Transplantation Volume: 26 Issue: 3 Pages: 509-518
  • DOI: 10.1016/j.bbmt.2019.09.035
  • Peer Reviewed
• [Journal Article] Prognostic factors for adult single cord blood transplantation among European and Japanese populations: the Eurocord/ALWP-EBMT and JSHCT/JDCHCT collaborative study (2019)
  • Author(s): Kanda Junya、Hayashi Hiromi、Ruggeri Annalisa、Kimura Fumihiko、Volt Fernanda、Takahashi Satoshi、et al.
  • Journal Title: Leukemia Volume: 34 Issue: 1 Pages: 128-137
  • DOI: 10.1038/s41375-019-0534-5
  • Peer Reviewed / Int'l Joint Research
• [Presentation] The impact of GVHD on outcomes after adult single cord blood transplantation in European and Japanese populations: the Eurocord/ALWP EBMT and JSHCT/JDCHCT collaborative study (2021)
  • Author(s): Kanda J, Hayashi H, Ruggeri A, Kimura F, Volt F, Takahashi S, Kako S, Tozatto-Maio K, Yanada M, Sanz G, Uchida N, Angelucci E, Kato S, Mohty M, Forcade E, Tanaka M, Sierra J, Ohta T, Saccardi R, Fukuda T, Ichinohe T, Kimura T, Rocha V, Okamoto S, Nagler A, Atsuta Y, Gluckman E.
  • Organizer: 47th Annual Meeting of the European Society for Blood and Marrow Transplantation
  • Int'l Joint Research
• [Presentation] Impact of GVHD on outcomes after adult single CBT in European and Japanese populations (2021)
  • Author(s): Kanda J, Hayashi H, Ruggeri A, Kimura F, Volt F, Takahashi S, Kako S, Tozatto-Maio K, Yanada M, Sanz G, Uchida N, Angelucci E, Kato S, Mohty M, Forcade E, Tanaka M, Sierra J, Ohta T, Saccardi R, Fukuda T, Ichinohe T, Kimura T, Rocha V, Okamoto S, Nagler A, Atsuta Y, Gluckman E.
  • Organizer: 第43回日本造血細胞移植学会総会
• [Presentation] 国際的視点から考える臍帯血移植成績の現状と未来 (2021)
  • Author(s): 諫田淳也
  • Organizer: 第43回日本造血細胞移植学会総会
  • Invited
• [Presentation] Impact of HLA and Haplotype Matching on Outcomes after Single-Unit Umbilical Cord Blood Transplantation (2019)
  • Author(s): Junya Kanda
  • Organizer: CORD BLOOD CONNECT
  • Int'l Joint Research / Invited
• [Presentation] 臍帯血移植におけるHLAハプロタイプ適合の意義 (2019)
  • Author(s): 諫田 淳也
  • Organizer: 第17回日本組織適合性学会近畿地方会
  • Invited
• [Presentation] ハプロタイプ適合度が単一臍帯血移植後の成績に与える影響：JSHCT HLA WG研究 (2019)
  • Author(s): Junya Kanda, Takakazu Kawase, Hidenori Tanaka, Naoyuki Uchida, Koji Nagafuji, Yoshiko Matsuhashi,Yuju Ono, Makoto Onizuka, Junji Tanaka, Tatsuo Ichinohe, Yoshiko Atsuta
  • Organizer: 第41回日本造血細胞移植学会総会
• [Presentation] Effect of haplotype on outcomes after adult single cord blood transplantation (2019)
  • Author(s): Junya Kanda, Takakazu Kawase, Hidenori Tanaka, Naoyuki Uchida, Koji Nagafuji, Yoshiko Matsuhashi,Yuju Ono, Makoto Onizuka, Junji Tanaka, Tatsuo Ichinohe, Yoshiko Atsuta
  • Organizer: 第45回欧州骨髄移植学会議
  • Int'l Joint Research
• [Presentation] ハプロタイプが単一臍帯血移植後の成績に与える影響：JSHCT HLA WG研究 (2019)
  • Author(s): Junya Kanda, Takakazu Kawase, Hidenori Tanaka, Naoyuki Uchida, Koji Nagafuji, Yoshiko Matsuhashi,Yuju Ono, Makoto Onizuka, Junji Tanaka, Tatsuo Ichinohe, Yoshiko Atsuta
  • Organizer: 第81回日本血液学会学術集会
• [Presentation] Prognostic factors for adult single cord blood transplantation among European and Japanese populations: the Eurocord/ALWP-EBMT and JSHCT/JDCHCT collaborative study. (2018)
  • Author(s): Kanda J, Hayashi H, Ruggeri A, Kimura F, Volt F, Takahashi S, Labopin M, Kako S, Tozatto-Maio K, Yano S, Sanz G, Uchida N, Van Lint M , Kato S, Mohty M, Milpied N, Kanamori H, Sierra J, Ohno Y, Saccardi R, Fukuda T, Ichinohe T, Takanashi M, Okamoto S, Nagler A, Atsuta Y, Gluckman E.
  • Organizer: 44th Annual Meeting of the EBMT.
  • Int'l Joint Research
• [Presentation] 欧州と日本における成人単一臍帯血移植における予後予測因子：Eurocord/EBMTとJSHCT/JDCHCTの国際共同研究. (2018)
  • Author(s): Kanda J, Hayashi H, Ruggeri A, Kimura F, Volt F, Takahashi S, Labopin M, Kako S, Tozatto-Maio K, Yano S, Sanz G, Uchida N, Van Lint M , Kato S, Mohty M, Milpied N, Kanamori H, Sierra J, Ohno Y, Saccardi R, Fukuda T, Ichinohe T, Takanashi M, Okamoto S, Nagler A, Atsuta Y, Gluckman E.
  • Organizer: 第80回日本血液学会学術集会.
• [Remarks] 成人単一臍帯血移植における予後予測因子を解明 －初の日欧国際共同研究－
  • URL: http://www.kyoto-u.ac.jp/ja/research/research_results/2019/190600_2.html