Sleep , metabolism and cognitive function
| Project/Area Number |
18K08531
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
楠 宜樹 兵庫医科大学, 医学部, 講師 (00792194)
庄司 拓仁 兵庫医科大学, 医学部, 講師 (40624044)
小西 康輔 兵庫医科大学, 医学部, 講師 (90532367)
角谷 学 兵庫医科大学, 医学部, 講師 (90755109)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 認知機能障害 / 睡眠障害 / 糖尿病 / 睡眠 / 認知機能 / 脳内ストレス / 睡眠・リズム障害 / 自律神経機能 / 炎症 / 血管障害 / 認知症 |
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| Outline of Final Research Achievements |
HDHCC cohort study was performed to examine the association between metabolic disorders and cognitive impairment. At the end of January 2021, a total of 449 patients, with 186 hippocampal atrophy evaluations, and 68 amyloid PET examination were registered. We reported the present status of blood glucose fluctuation in the Hanshin medical area and the usefulness of amyloid PET in the diagnosis of mild cognitive impairment. As a basic study, a complex sleep disorder model was established, and showed variety of behavior phenotype such as spatial memory disturbance, decreased action potential of parahippocampal gyrus region, lower pain threshold, decreased food intake / body weight, higher basal body temperature and physical activity. The involvement of the emotional system and the autonomic nervous system was speculated.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、現代社会のストレス状態を模倣しうる複合睡眠障害モデルの確立と、その行動生理学的問題点が抽出されてきた。本結果を解釈すると、現在のコロナ禍をはじめとする様々な社会的ストレスは、生体の恒常性に大きな影響を及ぼし、生活習慣病などの発症・進展に深くかかわることが予想される。このような社会的命題を解決しうる臨床コホートの構築も、本研究課題の重要な成果である。本研究課題により、臨床・基礎両面から睡眠障害を中心とした社会的ストレスの病態意義とその制御を目指したシステムが構築できたと考えている。
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Association of time in range with hemoglobin A1c, glycated albumin, and 1,5-anhydro-D-glucitol.2021
Author(s)
Ohigashi M, Osugi K, Kusunoki Y, Washio K, Matsutani S, Tsunoda T, Matsuo T, Konishi K, Katsuno K, Namba M, Koyama H
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Journal Title
Journal of Diabetes Investigation
Volume: 印刷中
Issue: 6
Pages: 940-949
DOI
Related Report
Peer Reviewed
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[Journal Article] Benefit of Early Add-on of Linagliptin to Insulin in Japanese Patients With Type 2 Diabetes Mellitus: Randomized-Controlled Open-Label Trial (TRUST2).2021
Author(s)
Katsuno T, Shiraiwa T, Iwasaki S, Park H, Watanabe N, Kaneko S, Terasaki J, Hanafusa T, Imagawa A, Iichiro Shimomura, Ikegami H, Koyama H, Namba M, Miyagawa J for TRUST2 study group
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Journal Title
Advances in Therapy
Volume: 38
Issue: 3
Pages: 1514-1535
DOI
Related Report
Peer Reviewed
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[Journal Article] Relationships between time in range, glycemic variability including hypoglycemia and types of diabetes therapy in Japanese patients with type 2 diabetes mellitus: HDHCC study.2021
Author(s)
Kuroda N, Kusunoki Y, Osugi K, Ohigashi M, Azuma D, Ikeda H, Makino S, Otsuka A, Tamada D, Watanabe N, Washio K, Tsunoda T, Matsuo T, Konishi K, Katsuno T, and Koyama H; Hyogo Diabetes Hypoglycemia Cognition Complications (HDHCC) study group
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Journal Title
Journal of Diabetes Investigation
Volume: 12
Issue: 2
Pages: 244-253
DOI
Related Report
Peer Reviewed
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[Journal Article] A Case of Pregnant Woman With Preexisting Type 2 Diabetes and Severe Diabetic Nephropathy Having Safely Given Birth by Multidisciplinary Therapy2020
Author(s)
大杉 敬子, 楠 宜樹, 鷲尾 佳穂里, 井上 智香子, 大東 真菜, 松谷 聡, 桝田 智仁, 角田 拓, 松尾 俊宏, 小西 康輔, 勝野 朋幸, 難波 光義, 小山 英則
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Journal Title
Journal of the Japan Diabetes Society
Volume: 63
Issue: 1
Pages: 35-40
DOI
NAID
ISSN
0021-437X, 1881-588X
Year and Date
2020-01-30
Related Report
Peer Reviewed
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[Journal Article] Xanthine oxidoreductase activity correlates with vascular endothelial dysfunction in patients with type 1 diabetes.2020
Author(s)
Washio K, Kusunoki Y, Tsunoda T, Osugi K, Ohigashi M, Murase T, Nakamura T, Matsuo T, Konishi K, Katsuno T, Namba M, Koyama H.
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Journal Title
Acta Diabetologica
Volume: 57
Issue: 1
Pages: 31-39
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Integral role of receptor for advanced glycation end products (RAGE) in nondiabetic atherosclerosis2019
Author(s)
Uekita H, Ishibashi T, Shiomi M, Koyama H, Ohtsuka S, Yamamoto H, Yamagishi S, Inoue H, Itabe H, Sugimoto K, Kamioka M, Ohkawara H, Wada I, Yasuchika T
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Journal Title
FUKUSHIMA JOURNAL OF MEDICAL SCIENCE
Volume: 65
Issue: 3
Pages: 109-121
DOI
NAID
ISSN
0016-2590, 2185-4610
Related Report
Peer Reviewed
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