Elucidation of molecular biological effect of prehabilitation for pancreaticoduodenectomy
Project/Area Number |
18K08655
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 55020:Digestive surgery-related
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Research Institution | Wakayama Medical University |
Principal Investigator |
Kawai Manabu 和歌山県立医科大学, 医学部, 准教授 (40398459)
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Co-Investigator(Kenkyū-buntansha) |
北畑 裕司 和歌山県立医科大学, 医学部, 学内助教 (00535338)
山上 裕機 和歌山県立医科大学, 医学部, 教授 (20191190)
岡田 健一 和歌山県立医科大学, 医学部, 講師 (50407988)
廣野 誠子 和歌山県立医科大学, 医学部, 講師 (60468288)
宮澤 基樹 和歌山県立医科大学, 医学部, 講師 (90549734)
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Project Period (FY) |
2018-04-01 – 2022-03-31
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Project Status |
Completed (Fiscal Year 2021)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 頭部領域癌 / アディポネクチン / サイトカイン / 術前運動療法 / 膵頭十二指腸切除術 / 術後合併症 / 膵頭部領域癌 / 運動療法 |
Outline of Final Research Achievements |
Exercise therapy significantly reduced adiponectin (11.2 ± 5.0 μg / ml before exercise, 9.5 ± 4.3 μg / ml after exercise, P = 0.003), but changes in adiponectin before and after exercise and the occurrence of postoperative complications There was no relevance. Pre-exercise adiponectin levels were no postoperative complications; 12.1 ± 5.3 μg / ml, postoperative complications; 9.2 ± 3.9 μg / ml, and pre-exercise adiponectin levels were significantly higher in patients with postoperative complications. It was a low value (P = 0.034). However, no association was found between post-exercise adiponectin levels and the occurrence of complications. The cut-off value for pre-exercise adiponectin, which predicts postoperative complications after pancreaticoduodenectomy, was 9.5 μg / ml.
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Academic Significance and Societal Importance of the Research Achievements |
高難度手術である膵頭十二指腸切除は手術侵襲が大きく術後合併症率は30~50%といまだ高率である。今回の研究で、膵頭十二指腸切除術後合併症を予測する運動療法前アディポネクチン値のカットオフ値は9.5μg/mlであり、運動療法前アディポネクチン値は膵頭十二指腸切除術後合併症の予測バイオマーカーとなりうることが示唆された。術前運動療法による膵頭十二指腸切除術後合併症高危険群を予測する運動療法前アディポネクチン値によって膵頭十二指腸切除術の周術期管理の新たなアルゴリズムの提唱ができる可能性がある。
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Report
(5 results)
Research Products
(18 results)
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[Journal Article] Preoperative In-Hospital Rehabilitation Improves Physical Function in Patients with Pancreatic Cancer Scheduled for Surgery2020
Author(s)
Yukio Mikami , Ken Kouda, Shinji Kawasaki, Ken-Ichi Okada, Manabu Kawai, Yuji Kitahata , Motoki Miyazawa, Seiko Hirono, Michiaki Unno, Fumihiro Tajima, Hiroki Yamaue
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Journal Title
The Tohoku Journal of Experimental Medicine
Volume: 251
Issue: 4
Pages: 279-285
DOI
NAID
ISSN
0040-8727, 1349-3329
Related Report
Peer Reviewed
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[Journal Article] Low lymphocyte monocyte ratio after neoadjuvant therapy predicts poor survival after pancreatectomy in patients with borderline resectable pancreatic cancer.2019
Author(s)
Kawai M, Hirono S, Okada KI, Miyazawa M, Shimizu A, Kitahata Y, Kobayashi R, Ueno M, Hayami S, Tanioka K, Yamaue H.
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Journal Title
Surgery
Volume: 165
Issue: 6
Pages: 1151-1160
DOI
Related Report
Peer Reviewed
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[Journal Article] Intensive perioperative rehabilitation improves surgical outcomes after pancreaticoduodenectomy2018
Author(s)
Kitahata Y, Hirono S, Kawai M, Okada KI, Miyazawa M, Shimizu A, Kobayashi R, Ueno M, Hayami S, Shimokawa T, Kouda K, Tajima F, Yamaue H.
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Journal Title
Langenbeck's Archives of Surgery
Volume: 403
Issue: 6
Pages: 711-718
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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