Development of a novel method for Induction of Fetal Immunological Tolerance using Maternal microchymerism
Project/Area Number |
18K09228
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 56040:Obstetrics and gynecology-related
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Research Institution | Osaka University |
Principal Investigator |
Endo Masayuki 大阪大学, 医学系研究科, 教授 (30644794)
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Co-Investigator(Kenkyū-buntansha) |
玉井 克人 大阪大学, 医学系研究科, 寄附講座教授 (20236730)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | 胎児 / 免疫寛容 / マイクロキメリズム / 間葉系幹細胞 / 細胞移植 / 胎児治療 |
Outline of Final Research Achievements |
The phenomenon of cell migration from the mother to the fetus during pregnancy is called maternal-microchimerism. This mechanism has been shown to cause a certain percentage of children to develop an immunological tolerance to cells of maternal origin. In this case, the child does not reject maternally derived cell transplants or proteins specific to the mother. In this study, we sought to increase the efficiency of induction of immune tolerance against maternal derived protein. By administering the mesenchymal stem cell mobilization factor, HMGB1, to pregnant mice, we hoped that more mesenchymal stem cells would be transferred from the maternal blood to the fetus. As a result, we were able to increase the efficiency of immune tolerance induction by about 4-fold.
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Academic Significance and Societal Importance of the Research Achievements |
母親由来細胞やタンパク質に対して免疫寛容があると、その子供は母親由来の細胞移植や、母親に特異的なタンパク質に対して拒絶反応を起こしません。 もし、子供に特殊な疾患があって、細胞移植治療や臓器移植、あるいはタンパク質補充療法などの治療が必要な場合、通常であれば免疫抑制剤を使用したり、治療前に化学療法や放射線療法などで骨髄抑制をする必要があります。しかし、免疫寛容が誘導されていれば、そのような処置も必要なく治療することが可能になります。
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Successful management of fetal hemolytic disease due to strong anti-Rh17 with plasma exchange and intrauterine transfusion in a woman with the D--phenotype.2020
Author(s)
Mimura K, Endo M, Takahashi A, Doi Y, Sakuragi M, Kiyokawa T, Taniguchi H, Kitabatake Y, Handa M, Tomimatsu T, Tomiyama Y, Isaka Y, Kimura T.
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Journal Title
International Journal of Hematology
Volume: 111
Issue: 1
Pages: 149-154
DOI
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Peer Reviewed / Open Access
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[Journal Article] Transcriptionally distinct mesenchymal stem/stromal cells circulate in fetus2019
Author(s)
Shimbo, T., Endo, M., Iwai; S., Kitayama, T., Ouchi, Y., Yamamoto, R., Takaki, E., Yamazaki, S., Nishida, M., Wang, X., Kikuchi, Y., Tomimatsu, T., Kaneda, Y., Kimura, T. Tamai, K
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Journal Title
Biochemical and Biophysical Research Communications
Volume: pii: S0006-291X(19)
Issue: 2
Pages: 30410-3
DOI
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Peer Reviewed / Open Access
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[Journal Article] Obstetric outcome in patients with a unicornuate uterus after laparoscopic resection of a rudimentary horn2018
Author(s)
Sawada, M. Kakigano, A. Matsuzaki, S. Takiuchi, T. Mimura, K. Kumasawa, K. Endo, M. Ueda, Y. Yoshino, K. Kimura, T.
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Journal Title
J Obstet Gynaecol Res
Volume: -
Issue: 6
Pages: 1080-1086
DOI
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Peer Reviewed / Open Access
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[Presentation] Mesenchymal stem cell can induce offspring’s immune tolerance against non!inherited antigens in murine Maternal!to!Fetal microchimeric model2018
Author(s)
Okada A, Endo M, Sasano K, Kawanishi Y, Owa T, Kajimoto E, Tanaka H, Kakigano A, Mimura K, Tomimatsu T, Tamai K, Kimura T.
Organizer
第70回日本産科婦人科学会
Related Report
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[Presentation] 出生前診断された先天性横隔膜ヘルニア症例における出生時週数と児の予後に関する検討2018
Author(s)
川西陽子, 遠藤誠之, 甘利昭一郎, 臼井規朗, 内田恵一, 漆原直人, 岡和田学, 金森 豊, 田口智章, 照井慶太, 豊島勝沼, 早川昌弘, 古川泰三, 横井暁子, 奥山宏臣.
Organizer
第54回日本周産期・新生児医学会
Related Report
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[Book] 胎児発育不全2018
Author(s)
金山 尚裕、池田 智明、味村和哉、遠藤誠之,他
Total Pages
196
Publisher
中外医学社
ISBN
9784498060906
Related Report