| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Compared with the cases of drug therapy without sublingual immunotherapy (SLIT), the total nasal medication score was lower in the group who received SLIT in both the cedar pollen dispersal period and the cypress pollen dispersal period. When peripheral blood mononuclear cells extracted from blood samples before and after the pollen dispersal period were stimulated with cedar pollen antigen, the amount of type 2 cytokine production increased significantly in the SLIT group compared with the drug therapy group. Similarly, suppression of type 2 cytokines was observed when stimulated with cypress pollen antigen, but the degree of inhibition was less than when stimulated with cedar pollen. Although cedar pollen and cypress pollen have a common antigen, the results suggest the influence of antigens peculiar to cypress pollen such as Cha 0 3.
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