Evaluation of oral pathology that can cause sudden death - by Autopsy imaging
Project/Area Number |
18K09872
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 57080:Social dentistry-related
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Research Institution | Hokkaido University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
兵頭 秀樹 北海道大学, 医学研究院, 准教授 (30306154)
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Project Period (FY) |
2018-04-01 – 2022-03-31
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Project Status |
Completed (Fiscal Year 2021)
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Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 突然死 / autopsy imaging / 口腔体積 / 口腔air space / 閉塞性睡眠時無呼吸症候群 / 口腔容積 / sleep apnea / 閉塞性睡眠時無呼吸 / 口腔病態 / autopsy |
Outline of Final Research Achievements |
This study sought to clarify the relationship between oral air space volume and obstructive sleep apnea syndrome (OSAS) onset, which is influenced by multiple factors, such as jawbone, dentition morphology, and oral soft-tissue volume. (1)50 subjects from deceased cases were divided into two groups: OSAS (25 subjects) and controls (25 subjects). (2) 33 subjects from clinical cases were divided into two groups: OSAS (9 subjects) and controls (24 subjects). In all cases, the CT images of the facial region were obtained, and four parameters of oral area volume were analyzed in deceased and clinical cases, and comparisons and analyses were performed between OSAS and control cases. In deceased cases, oral soft-tissue volume (OSV), oral air-space volume (OAV), and the ratio of OAV to OSV (%air) showed a significant correlation. In clinical cases, OAV and %air showed a significant correlation. Furthermore, the evaluation including the pharyngeal area were similar to this results.
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Academic Significance and Societal Importance of the Research Achievements |
閉塞性睡眠時無呼吸症候群(OSAS)は、睡眠中に繰り返し起こる呼吸停止を特徴とする睡眠障害で、循環器疾患等の重篤な合併症を引き起こし、突然死の原因となる疾患として知られている。死後・臨床例ともに、口腔体積に対する口腔air space体積の比(%air)、口腔咽頭腔体積に対する口腔咽頭領域のair space volumeの比(%air’)の値が小さければ、OSAS発症のリスクが高く、OSASによる突然死の可能性が高いことが示された。咽頭領域を含めた検証でも、口腔領域のみの計測と同様の結果となった。突然死を惹起しやすい口腔形態がCTで評価でき、突然死の原因の一つを早期に評価可能となった。
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Report
(5 results)
Research Products
(17 results)
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[Journal Article] Quantification of Joint Space Width Difference on Radiography Via Phase-Only Correlation (POC) Analysis: a Phantom Study Comparing with Various Tomographical Modalities Using Conventional Margin-Contouring2021
Author(s)
Aimi Taguchi, Shun Shishido, Yafei Ou, Masayuki Ikebe, Tianyu Zeng, Wanxuan Fang, Koichi Murakami, Toshikazu Ueda, Nobutoshi Yasojima, Keitaro Sato, Kenichi Tamura, Kenneth Sutherland, Nozomi Oki, Ko Chiba, Kazuyuki Minowa, Masataka Uetani & Tamotsu Kamishima
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Journal Title
Journal of Digital Imaging
Volume: 34
Issue: 1
Pages: 96-104
DOI
Related Report
Peer Reviewed
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[Journal Article] Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment2019
Author(s)
Dorcas Akuba Muhyia Annan, Nako Maishi, Tomoyoshi Soga, Randa Dawood, Cong Li, Hiroshi Kikuchi, Takayuki Hojo, Masahiro Morimoto, Tetsuya Kitamura, Mohammad Towfik Alam, Kazuyuki Minowa, Nobuo Shinohara, Jin-Min Nam, Yasuhiro Hida, Kyoko Hida
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Journal Title
Cell Communication and Signaling
Volume: 17
Issue: 1
Pages: 169-169
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Adenovirus infection induces HuR relocalization to facilitate virus replication2018
Author(s)
Jumond P. Jehung , Tetsuya Kitamura , Aya Yanagawa-Matsuda , Takeshi Kuroshima , Alam Towfik , Motoaki Yasuda , Hidehiko Sano, Yoshimasa Kitagawa , Kazuyuki Minowa, Masanobu Shindoh, Fumihiro Higashino
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Journal Title
Biochemical and Biophysical Research Communications
Volume: 495
Pages: 1795-1800
Related Report
Peer Reviewed / Open Access
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[Book] 歯科放射線学2022
Author(s)
金田隆 奥村泰彦 村上秀明 箕輪和行
Total Pages
128
Publisher
永末書店
Related Report
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[Book] 歯科放射線学2021
Author(s)
岡野友宏 小林馨 有地栄一郎
Total Pages
504
Publisher
医歯薬出版
Related Report
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