| Project/Area Number |
18K09983
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 58010:Medical management and medical sociology-related
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| Research Institution | Keio University |
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Principal Investigator |
ISAWA MINAE 慶應義塾大学, 薬学部(芝共立), 研究員 (10338006)
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| Co-Investigator(Kenkyū-buntansha) |
青森 達 慶應義塾大学, 薬学部(芝共立), 准教授 (40620802)
望月 眞弓 慶應義塾大学, 薬学部(芝共立), 特任教授 (60292679)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | プラセボ効果 / 脳内化学伝達物質 / 脳前頭前野活性 / NIRS / COMT / 5-HTT / 5HTT / パーソナリティ / プラセボーム解析 / 脳科学的アプローチ（NIRS) / 5HTT遺伝子多型 / COMT遺伝子多型 / プラセボーム研究 |
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| Outline of Final Research Achievements |
The "placebo effect" is a psychological phenomenon in which the efficacy of a drug is enhanced by conditioning such as expectation of the drug or experience that the drug has worked in the past. The placebo effect is more likely to appear in people with positive thoughts, and we focused on the possibility that differences in the secretion of chemical transmitters in the brain may be involved. In this study, healthy adults were given a verbal explanation of the anti-drowsiness effects of caffeine and then given a placebo. Many of them improved their sleepiness and also increased their brain activity. It was suggested that the placebo effect was related to brain activation. In terms of brain chemical transmitters, the placebo effect tended to be stronger in people with certain genotypes.
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| Academic Significance and Societal Importance of the Research Achievements |
医薬品の薬効が現れるにはプラセボ効果もその要素の一つである。脳前頭前野がプラセボ効果の認知に関わる部位として研究が進み、服薬指導での説明がその効果に影響を与えることが認められた。プラセボ効果のメカニズムの解明は、医薬品の開発における適切な設計へと導くことができる。気分を変える脳内化学伝達物質の分布の違いは個人差がみられることから、患者特性による服薬指導の適切化をはかり最適な治療へと応用ができる。
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