Thyroid function disrupting effects of fetal exposure to POPs on ADHD symptoms in children
| Project/Area Number |
18K10042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 58020:Hygiene and public health-related: including laboratory approach
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| Research Institution | Hokkaido University |
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Principal Investigator |
Itoh Sachiko 北海道大学, 環境健康科学研究教育センター, 特任講師 (90580936)
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| Co-Investigator(Kenkyū-buntansha) |
荒木 敦子 北海道大学, 環境健康科学研究教育センター, 特任教授 (00619885)
山崎 圭子 北海道大学, 環境健康科学研究教育センター, 特任講師 (60732120)
須山 聡 北海道大学, 大学病院, 特任助教 (70758581)
岸 玲子 北海道大学, 環境健康科学研究教育センター, センター特別招へい教授 (80112449)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 出生コホート / 胎児期曝露 / 内分泌攪乱作用 / 甲状腺ホルモン / 甲状腺抗体 / 注意欠如多動症 / POPｓ / 抗甲状腺抗体 / ADHD / 出生前向きコホート / POPs |
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| Outline of Final Research Achievements |
We investigated the associations between prenatal exposure to perfluoroalkyl substances(PFASs) and the thyroid hormones(THs) and thyroid antibodies(TAs) in maternal and cord blood while considering maternal TAs status. Maternal PFASs were differently associated with THs and TAs of children between in maternal TA-negative group and TAs-positive group, and between boys and girls. Additionally, we investigated the impact of maternal PFAS exposure on children’s attention deficit hyperactive disorder(ADHD) symptoms at 8 years with the mediating effect of TH and TA. Significant inverse associations were found between some PFASs in maternal serum and ADHD symptoms among firstborn children. Assuming causality, we found only one significance: the maternal FT4 mediated 16.3% of the estimated effect of PFUnDA exposure on hyperactivity-impulsivity among firstborn children.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、出生後の児の神経発達に重要な役割を果たす母児の甲状腺ホルモンについて、妊娠中の有機フッ素化合物（PFASs）への曝露との関連があること、およびその関連における母の甲状腺ホルモン抗体の関与の可能性を示唆した。妊娠中のPFASs曝露は発達障害のひとつである注意欠如多動症（ADHD）の発症とも関連することが指摘されている。本研究の結果からは甲状腺ホルモン・甲状腺抗体の媒介はわずかであったが、これらの結果は妊娠中のPFASs曝露と子どものADHD発症メカニズム解明の糸口となることが期待される。
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Association of Maternal Serum Concentration of Hydroxylated Polychlorinated Biphenyls with Maternal and Neonatal Thyroid Hormones: The Hokkaido Birth Cohort Study2018
Author(s)
Itoh S., Baba T., Yuasa M., Miyashita C., Kobayashi S., Araki A., Sasaki S., Kajiwara J., Hori T., Todaka T., Fujikura K., Nakajima S., Kato S., Kishi R.
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Journal Title
Environmental Research
Volume: 167
Pages: 583-590
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association of prenatal exposure to PCDD/Fs and PCBs with maternal and infant thyroid hormones: The Hokkaido Study on Environment and Children's Health.2018
Author(s)
Baba T., Ito S., Yuasa M., Yoshioka E., Miyashita C., Araki A., Sasaki S., Kobayashi S., Kajiwara J., Hori T., Kato S., Kishi R
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Journal Title
Sci Total Environ
Volume: 615
Pages: 1239-1246
NAID
Related Report
Peer Reviewed / Open Access
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