Effects of Melatonin Brain Metabolites on Restoring Age-Related Long-Term Memory Impairment and its Application to Human Health Foods

• Project/Area Number: 18K11016
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: HATTORI Atsuhiko 東京医科歯科大学, 教養部, 教授 (70183910)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: AMK / AFMK / メラトニン / 記憶力改善 / 加齢 / 物体認識試験 / マウス / 食品 / 学習 / 長期記憶 / レセプター / ＡＭＫ / LC/MS/MS / 記憶 / 食材 / 健康食品 / 加齢性記憶障害

Outline of Final Research Achievements

Melatonin, which has attracted attention as an anti-aging hormone, is metabolized in the brain mainly through N-acetyl-N-formyl-5-methoxykynuramine (AFMK) to N-acetyl-5-methoxykynuramine (AMK). Therefore, we investigated the effects of melatonin, AFMK and AMK on learning and memory in mice and found that AMK has a strong long-term memory-inducing effect. In addition, when the effects of AMK were tested in aged mice, whose long-term memory formation ability had declined due to aging, it was found that a single administration of AMK was sufficient to restore the reduced memory ability, which was reported in 2021 in the Journal of Pineal Research, the world's leading international scientific journal in the field of physiology. Another objective of this research is to lay the foundation for its deployment in humans. To this end, the melatonin , AFMK, and AMK contents were determined in over 150 foodstuffs using LC/MS/MS.

Academic Significance and Societal Importance of the Research Achievements

高齢者の記憶力の低下は、本人だけでなく社会全体のQOLの低下につながるため、その予防や改善のための薬物や機能性食品の開発は喫緊の課題である。メラトニンは、「夜の時刻情報の伝達物質」として生体リズム(睡眠相)を制御する作用が知られ、現在、睡眠改善薬としても利用されている。本研究では、メラトニンが脳内で代謝されてできるAMKに長期記憶誘導効果があることを見出し、老齢マウスにおいても低下した記憶能力を回復させることを見出した。この結果は、今後この研究を進めることで、超高齢社会における高齢者の認知機能改善に寄与できるものと思われる。

Research Products

• [Journal Article] 睡眠とメラトニン (2023)
  • Author(s): 服部淳彦
  • Journal Title: Anti-Aging Medicine Volume: 19 Pages: 6-11
• [Journal Article] ゾウリムシの遊泳行動の日周および概日変化とメラトニンの影響 (2023)
  • Author(s): 丸岩美結, 丸山雄介, 服部淳彦
  • Journal Title: 東京医科歯科大学教養部研究紀要 Volume: 53 Pages: 35-42
• [Journal Article] Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeasure (2022)
  • Author(s): Hirayama Jun、Hattori Atsuhiko、Takahashi Akihisa、Furusawa Yukihiro、Tabuchi Yoshiaki、Shibata Masahiro、Nagamatsu Aiko、Yano Sachiko、Maruyama Yusuke、Matsubara Hajime、Sekiguchi Toshio、Suzuki Nobuo
  • Journal Title: Journal of Pineal Research Volume: 74 Issue: 1
  • DOI: 10.1111/jpi.12834
  • Peer Reviewed / Open Access
• [Journal Article] Functional analysis of a matrix peptide involved in calcification of the exoskeleton of the kuruma prawn, Marsupenaeus japonicus (2022)
  • Author(s): Sekimoto Aika、Ohira Tsuyoshi、Shigematsu Atsushi、Okumura Takuji、Mekuchi Miyuki、Toyota Kenji、Mishima Hiroyuki、Kawamura Ryoya、Hatano Kaito、Kawago Umi、Kitani Yoichiro、Sekiguchi Toshio、Amornsakun Thumronk、Hirayama Jun、Hattori Atsuhiko、Matsubara Hajime、Suzuki Nobuo
  • Journal Title: Aquaculture Volume: 559 Pages: 738437-738437
  • DOI: 10.1016/j.aquaculture.2022.738437
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Osteoclastic and Osteoblastic Responses to Hypergravity and Microgravity: Analysis Using Goldfish Scales as a Bone Model (2022)
  • Author(s): Yamamoto Tatsuki、Ikegame Mika、Furusawa Yukihiro、Tabuchi Yoshiaki、Hatano Kaito、Watanabe Kazuki、Kawago Umi、Hirayama Jun、Yano Sachiko、Sekiguchi Toshio、Kitamura Kei-ichiro、Endo Masato、Nagami Arata、Matsubara Hajime、Maruyama Yusuke、Hattori Atsuhiko、Suzuki Nobuo
  • Journal Title: Zoological Science Volume: 39 Issue: 4 Pages: 388-396
  • DOI: 10.2108/zs210107
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hydroxylated benzo[c]phenanthrene metabolites cause osteoblast apoptosis and skeletal abnormalities in fish (2022)
  • Author(s): Suzuki Nobuo, Honda Masato, Sekiguchi Toshio, Toriba Akira, Tang Ning, Edward Nagato Go, Zhang Lulu, Hayakawa Kazuichi, et all.
  • Journal Title: Ecotoxicology and Environmental Safety Volume: 234 Pages: 113401-113401
  • DOI: 10.1016/j.ecoenv.2022.113401
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Associations Between Dietary Melatonin Intake and Total and Cause-Specific Mortality Among Japanese Adults in the Takayama Study (2021)
  • Author(s): Nagata Chisato、Wada Keiko、Yamakawa Michiyo、Nakashima Yuma、Koda Sachi、Uji Takahiro、Onuma Sakiko、Oba Shino、Maruyama Yusuke、Hattori Atsuhiko
  • Journal Title: American Journal of Epidemiology Volume: 190 Issue: 12 Pages: 2639-2646
  • DOI: 10.1093/aje/kwab213
  • Peer Reviewed / Open Access
• [Journal Article] The melatonin metabolite N1‐acetyl‐5‐methoxykynuramine facilitates long‐term object memory in young and aging mice (2021)
  • Author(s): Iwashita Hikaru、Matsumoto Yukihisa、Maruyama Yusuke、Watanabe Kazuki、Chiba Atsuhiko、Hattori Atsuhiko
  • Journal Title: Journal of Pineal Research Volume: 70 Issue: 1 Pages: 1-11
  • DOI: 10.1111/jpi.12703
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Antioxidant in Adjunct with Periodontal Therapy in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis (2021)
  • Author(s): Koji Mizutani, Prima Buranasin, Risako Mikami, Kohei Takeda, Daisuke Kido, Kazuki Watanabe, Shu Takemura, Keita Nakagawa, Hiromi Kominato, Natsumi Saito, Atsuhiko Hattori, Takanori Iwata.
  • Journal Title: Antioxidants Volume: 10 Issue: 8 Pages: 1304-1304
  • DOI: 10.3390/antiox10081304
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oral administration of melatonin increases plasma calcium and magnesium and improves bone metabolism in aged male mice (2021)
  • Author(s): Igarashi-Migitaka Junko、Maruyama Yusuke、Seki Azusa、Hirayama Jun、Kamijo-Ikemori Atsuko、Hirata Kazuaki、Kawamura Ryoya、Matsubara Hajime、Srivastav Ajai K、Tabuchi Yoshiaki、Mishima Hiroyuki、Hattori Atsuhiko、Suzuki Nobuo
  • Journal Title: Melatonin Research Volume: 4 Issue: 4 Pages: 581-591
  • DOI: 10.32794/mr112500113
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glyoxal‐induced formation of advanced glycation end‐products in type 1 collagen decreases both its strength and flexibility in vitro (2021)
  • Author(s): Kitamura Kei‐ichiro、Hirayama Jun、Tabuchi Yoshiaki、Minami Takao、Matsubara Hajime、Hattori Atsuhiko、Suzuki Nobuo
  • Journal Title: Journal of Diabetes Investigation Volume: 12 Issue: 9 Pages: 1555-1559
  • DOI: 10.1111/jdi.13528
  • Peer Reviewed / Open Access
• [Journal Article] In Vivo Suppression of Osteoclastic and Osteoblastic Activities of Goldfish Scales in Water Containing Cadmium (2021)
  • Author(s): Suzuki N, Kawago U, Honda M, Srivastav AK, Amornsakun T, Matsumoto K, Hirayama J, Matsubara H, Shimizu N, Sekiguchi T, Sasayama Y, Tabuchi Y, Hattori A, Shimasaki Y, Oshima Y
  • Journal Title: Journal of the Faculty of Agriculture, Kyushu University Volume: 66 Issue: 2 Pages: 199-203
  • DOI: 10.15017/4486551
  • NAID: 120007143908
  • ISSN: 0023-6152
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Porphyromonas gingivalis impairs glucose uptake in skeletal muscle associated with altering gut microbiota (2020)
  • Author(s): Watanabe K、Katagiri S、Takahashi H、Sasaki N、Maekawa S、Komazaki Ri、Hatasa M、Kitajima Y、Maruyama Y、Shiba T、Komatsu K、Ohsugi Y、Tanaka K、Matsuzawa A、Hirota T、Tohara H、Eguchi Y、Anzai K、Hattori A、Iwata T
  • Journal Title: The FASEB Journal Volume: 35 Issue: 2 Pages: 1-16
  • DOI: 10.1096/fj.202001158r
  • Peer Reviewed / Open Access
• [Journal Article] Uptake of Osteoblast-Derived Extracellular Vesicles Promotes the Differentiation of Osteoclasts in the Zebrafish Scale (2020)
  • Author(s): Jingjing Kobayashi-Sun, Shiori Yamamori, Mao Kondo, Junpei Kuroda, Mika Ikegame, Nobuo Suzuki, Kei-Ichiro Kitamura, Atsuhiko Hattori, Masaaki Yamaguchi, Isao Kobayashi.
  • Journal Title: Communications Biology Volume: 3 Issue: 1 Pages: 190-190
  • DOI: 10.1038/s42003-020-0925-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Melatonin suppresses both osteoblast and osteoclast differentiation through repression of epidermal Erk signaling in the zebrafish scale (2020)
  • Author(s): Kobayashi-Sun Jingjing、Suzuki Nobuo、Hattori Atsuhiko、Yamaguchi Masaaki、Kobayashi Isao
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 530 Issue: 4 Pages: 644-650
  • DOI: 10.1016/j.bbrc.2020.07.075
  • Peer Reviewed
• [Journal Article] De novo transcriptome analysis and gene expression profiling of fish scales isolated from Carassius auratus during space flight: Impact of melatonin on gene expression in response to space radiation (2020)
  • Author(s): Furusawa Yukihiro、Yamamoto Tatsuki、Hattori Atsuhiko、Suzuki Nobuo、Hirayama Jun、Sekiguchi Toshio、Tabuchi Yoshiaki
  • Journal Title: Molecular Medicine Reports Volume: 22 Pages: 2627-2636
  • DOI: 10.3892/mmr.2020.11363
  • Peer Reviewed / Open Access
• [Journal Article] Oral administration of melatonin contained in drinking water increased bone strength in naturally aged mice (2020)
  • Author(s): Igarashi-Migitaka Junko、Seki Azusa、Ikegame Mika、Honda Masato、Sekiguchi Toshio、Mishima Hiroyuki、Shimizu Nobuaki、Matsubara Hajime、Srivastav Ajai K.、Hirayama Jun、Maruyama Yusuke、Kamijo-Ikemori Atsuko、Hirata Kazuaki、Hattori Atsuhiko、Suzuki Nobuo
  • Journal Title: Acta Histochemica Volume: 122 Issue: 6 Pages: 151596-151596
  • DOI: 10.1016/j.acthis.2020.151596
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Influence of Benz[a]anthracene on Bone Metabolism and on Liver Metabolism in Nibbler Fish, Girella punctata (2020)
  • Author(s): Zanaty Mohamed I.、Sawada Niina、Kitani Yoichiro、Nassar Hossam F.、Mahmoud Hamada M.、Hayakawa Kazuichi、Sekiguchi Toshio、Ogiso Shouzo、Tabuchi Yoshiaki、Urata Makoto、Matsubara Hajime、Takeuchi Yutaka、Hattori Atsuhiko、Srivastav Ajai K.、Amornsakun Thumronk、Suzuki Nobuo
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 17 Issue: 4 Pages: 1391-1391
  • DOI: 10.3390/ijerph17041391
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The use of chemical compounds to identify the regulatory mechanisms of vertebrate circadian clocks. (2020)
  • Author(s): Nishimura A, Izawa J, Hattori A, Suzuki N, Hirayama J# #Corresponding author
  • Journal Title: Curr Drug Targets. Volume: 21 Issue: 5 Pages: 425-432
  • DOI: 10.2174/1389450120666190926143120
  • Peer Reviewed
• [Journal Article] Expression of sclerostin in the regenerating scales of goldfish and its increase under microgravity during space flight (2020)
  • Author(s): Tatsuki YAMAMOTO, Mika IKEGAME, Jun HIRAYAMA, Kei-ichiro KITAMURA, Yoshiaki TABUCHI, Yukihiro FURUSAWA, Toshio SEKIGUCHI, Masato ENDO, Hiroyuki MISHIMA, Azusa SEKI, Sachiko YANO, Hajime MATSUBARA, Atsuhiko HATTORI, and Nobuo SUZUKI
  • Journal Title: Biomedical Research (Tokyo) Volume: 41 Pages: 279-288
  • NAID: 130007948844
  • Peer Reviewed
• [Journal Article] Melatonin is a potential drug for the prevention of bone loss during space flight (2019)
  • Author(s): Ikegame Mika、7名、Sekiguchi Toshio、43名、Suzuki Nobuo
  • Journal Title: Journal of Pineal Research Volume: 67 Issue: 3 Pages: 1-13
  • DOI: 10.1111/jpi.12594
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Suppressive effect of melatonin on osteoclast function via osteocyte calcitonin (2019)
  • Author(s): Nakano Masaki、Ikegame Mika、Igarashi-Migitaka Junko、Maruyama Yusuke、Suzuki Nobuo、Hattori Atsuhiko
  • Journal Title: Journal of Endocrinology Volume: 242 Issue: 2 Pages: 13-23
  • DOI: 10.1530/joe-18-0707
  • Peer Reviewed / Open Access
• [Journal Article] Circadian production of melatonin in cartilage modifies rhythmic gene expression (2019)
  • Author(s): Fu Shanqi、Kuwahara Miho、Uchida Yoko、Kondo Sei、Hayashi Daichi、Shimomura Yuji、Takagaki Asami、Nishida Takashi、Maruyama Yusuke、Ikegame Mika、Hattori Atsuhiko、Kubota Satoshi、Hattori Takako
  • Journal Title: Journal of Endocrinology Volume: 241 Issue: 2 Pages: 161-173
  • DOI: 10.1530/joe-19-0022
  • NAID: 120006801909
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Suppression of Blue Light at Night Ameliorates Metabolic Abnormalities by Controlling Circadian Rhythms (2019)
  • Author(s): Nagai Norihiro、Ayaki Masahiko、Yanagawa Tatsuo、Hattori Atsuhiko、Negishi Kazuno、Mori Takuro、Nakamura Takahiro J.、Tsubota Kazuo
  • Journal Title: Investigative Opthalmology & Visual Science Volume: 60 Issue: 12 Pages: 3786-3793
  • DOI: 10.1167/iovs.19-27195
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The clock components Period2, Cryptochrome1a, and Cryptochrome2a function in establishing light-dependent behavioral rhythms and/or total activity levels in zebrafish (2019)
  • Author(s): Hirayama J, Alifu Y, Hamabe R, Yamaguchi S, Tomita J, Maruyama Y, Asaoka Y , Nakahama K, Tamaru T, Takamatsu K, Takamatsu N, Hattori A, Nishina S, Azuma N, Kawahara A, Kume K, Nishina H.
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 196-196
  • DOI: 10.1038/s41598-018-37879-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of mats with “A Distinctive 4-Layer 3 -Dimensional Structure” on sleep quality and nocturnal blood glucose: A crossover trial. (2019)
  • Author(s): Mari Ogura, Atsuhiko Hattori, Masayuki Yagi, Wakako Takabe, Takuto Nonomura, Yoji Shimura, Midori Ando, Yoshikazu Yonei
  • Journal Title: Glycative Stress Research Volume: 6 Issue: 1 Pages: 49-63
  • DOI: 10.24659/gsr.6.1_49
  • NAID: 130007656800
  • ISSN: 2188-3602, 2188-3610
  • Peer Reviewed / Open Access
• [Journal Article] Development of a system for measuring calcitonin in the stingray Dasyatis akajei (a cartilaginous fish): the possible involvement of stingray calcitonin in gonadal development. (2019)
  • Author(s): Takagi, T., Sekiguchi, T., Sasayama, Y., Hattori, A., Watanabe, T.X., Kitani, Y., Tabuchi, Y., Matsubara, H., Srivastav, A.K., Hai, T.N., Amornsakun, T. and Suzuki, N.
  • Journal Title: Int. Aqua. Res Volume: 11 Pages: 267-276
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Post-translational Modifications are Required for Circadian Clock Regulation in Vertebrates (2019)
  • Author(s): Okamoto-Uchida Yoshimi、Izawa Junko、Nishimura Akari、Hattori Atsuhiko、Suzuki Nobuo、Hirayama Jun
  • Journal Title: Current Genomics Volume: 20 Issue: 5 Pages: 332-339
  • DOI: 10.2174/1389202919666191014094349
  • Peer Reviewed
• [Journal Article] a-melanocyte-stimulating hormone promotes the bone resorption resulting from increased osteoblastic and osteoclastic activities in goldfish. (2018)
  • Author(s): Ishizu, H., Sekiguchi, T., Ikari, T.,, Kitamura, K., Kitani, Y., Endo, M., Urata, M., Kinoshita, Y., Hattori, A., Srivastav, A.K., Mishima, H., Mizusawa, K., Takahashi, A. and Suzuki, N.
  • Journal Title: Gen. Comp. Endocrinol. Volume: 262 Pages: 99-105
  • DOI: 10.1016/j.ygcen.2018.03.020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] RANKL, Ephrin-Eph and Wnt10b are key intercellular communication molecules regulating bone remodeling in autologous transplanted goldfish scales (2018)
  • Author(s): Tazaki Yuya、Sugitani Kayo、Ogai Kazuhiro、Kobayashi Isao、Kawasaki Haruki、Aoyama Takafumi、Suzuki Nobuo、Tabuchi Yoshiaki、Hattori Atsuhiko、Kitamura Kei-ichiro
  • Journal Title: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology Volume: 225 Pages: 46-58
  • DOI: 10.1016/j.cbpa.2018.06.011
  • Peer Reviewed / Open Access
• [Journal Article] Effect of melatonin intake on postprandial blood glucose in the breakfast (2018)
  • Author(s): Ogura M, Okuda F, Hattori A, Takabe W, Yagi M, Yonei Y.
  • Journal Title: Glycative Stress Research Volume: 5 Issue: 2 Pages: 75-81
  • DOI: 10.24659/gsr.5.2_75
  • NAID: 130007432333
  • ISSN: 2188-3602, 2188-3610
  • Peer Reviewed / Open Access
• [Journal Article] Sequencing and expression analysis of calcitonin receptor in the scales of goldfish (Carassius auratus) (2018)
  • Author(s): Ikari, T., Sekiguchi, T., Urata, M., Furusawa, Y., Ikegame, M., Kinoshita, Y., Kitamura, K., Nakabayashi, I., Horita, M., Tabuchi, Y., Hattori, A., Srivastav, A.K. and Suzuki, N.
  • Journal Title: International Journal of Zoological Investigations Volume: 4 Pages: 1-10
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 新しいメラニン重合評価系を用いたプラセンタにおける美白有効成分の同定 (2018)
  • Author(s): 服部淳彦
  • Journal Title: 日本胎盤臨床医学会研究要覧 Volume: 22 Pages: 81-96
• [Journal Article] メラトニン－睡眠とアンチエイジング (2018)
  • Author(s): 服部淳彦
  • Journal Title: 全薬Journal Volume: 284 Pages: 10-13
• [Presentation] メラトニンとアンチエイジング (2023)
  • Author(s): 服部淳彦
  • Organizer: 日本抗加齢医学会 講習会
  • Invited
• [Presentation] メラトニン－睡眠と記憶 (2022)
  • Author(s): 服部淳彦
  • Organizer: 第13回抗加齢内分泌研究会
  • Invited
• [Presentation] 長期記憶誘導作用を持つメラトニン代謝産物AMKの加齢変化と記憶関連因子に与える影響. (2022)
  • Author(s): 渡辺数基, 丸山雄介, 服部淳彦
  • Organizer: 第41回日本認知症学会
• [Presentation] 長期記憶誘導作用を持つメラトニン代謝産物AMKの連続投与による記憶形成能への影響. (2022)
  • Author(s): 丸山雄介, 渡辺数基, 服部淳彦
  • Organizer: 第41回日本認知症学会
• [Presentation] 長期記憶を誘導するメラトニン代謝産物AMKはキンギョの脳における記憶形成関連因子を促進する. (2022)
  • Author(s): 榊原和眞, 渡辺数基, 丸山雄介, 服部淳彦
  • Organizer: 第46回日本比較内分泌学会大会及びシンポジウム
• [Presentation] キンギョにおける学習・記憶試験 Object Recognition Test(ORT)の確立 (2022)
  • Author(s): 毛利有沙, 田中美咲妃, 渡辺数基, 丸山雄介, 服部淳彦
  • Organizer: 第46回日本比較内分泌学会大会及びシンポジウム
• [Presentation] がんの骨浸潤時に上昇する低酸素誘導因子HIFによる破骨細胞の調節機構－キンギョの再生鱗を用いて－ (2022)
  • Author(s): 飯田穀, 福井宏明, 丸山雄介, 渡辺数基, 鈴木信雄, 服部淳彦
  • Organizer: 第46回日本比較内分泌学会大会及びシンポジウム
• [Presentation] Effects of social isolation in crickets Gryllus bimaculatus. (2022)
  • Author(s): 寺尾寛太, 神前裕, 丸山雄介, 服部淳彦, 松本幸久
  • Organizer: 動物心理学会 第82回大会
• [Presentation] 高純度次亜塩素酸水がマウスの糖代謝に与える影響の解明 (2022)
  • Author(s): 渡辺数基, 丸山雄介, 三上理沙子, 駒津匡二, 服部淳彦, 荒川真一
  • Organizer: 日本機能水学会第20回学術大会
• [Presentation] 社会的隔離が連合学習や報酬への応答に与える影響. (2022)
  • Author(s): 寺尾勘太, 神前裕, 服部淳彦, 松本幸久.
  • Organizer: 日本動物学会第93回早稲田大会
• [Presentation] 老齢マウスにおける内因性のメラトニン代謝産物AMKの変化と加齢に伴う記憶関連遺伝子の網羅的解析. (2022)
  • Author(s): 渡辺数基, 丸山雄介, 服部淳彦
  • Organizer: 第22回日本抗加齢医学会総会
• [Presentation] 特異的に浅海に棲むマシコヒゲムシ Oligobrachia mashikoiの生息状況及び光環境への適応. (2022)
  • Author(s): 小木曽正造, 渡辺数基, 三宅裕志, 丸山雄介, 平山順, 服部淳彦, 関口俊男, 端野開都, 木谷洋一郎, 渡部雪菜, 松原創, 笹山雄一, 鈴木信雄.
  • Organizer: 日本動物学会第93回早稲田大会
• [Presentation] 能登半島九十九湾に生息するアカテガニ（Chiromantes haematocheir）の幼生の生理・生態学的研究. (2022)
  • Author(s): 川村龍矢, 馬久地みゆき, 豊田賢治, 小木曽正造, 渡部雪菜, 永見新, 丸山雄介, 服部淳彦,平山順, 柳井清治, 松原創, 鈴木信雄
  • Organizer: 日本動物学会第93回早稲田大会
• [Presentation] メラトニンと糖代謝 (2019)
  • Author(s): 服部淳彦
  • Organizer: 第11回抗加齢内分泌研究会
  • Invited
• [Presentation] マウスにおける内因性メラトニン代謝産物N-acetyl-5-methoxykynuramine(AMK)と海馬における糖取込みとの関連 (2019)
  • Author(s): 張賢, 丸山雄介, 岩下洸, 服部淳彦
  • Organizer: 日本動物学会関東支部第71回大会
• [Presentation] キンギョの鱗においてノルアドレナリン(NA)の刺激で合成されるN-acetyl-5-methoxykynuramine(AMK)は骨芽細胞を活性化する. (2019)
  • Author(s): 河村平, 小泉なぎさ, 丸山雄介, 服部淳彦
  • Organizer: 日本動物学会関東支部第71回大会
• [Presentation] メラトニン(MEL)はキンギョの脳における糖の取込みを促進する. (2019)
  • Author(s): 岡田玲那, 渡辺数基, 丸山雄介, 服部淳彦
  • Organizer: 日本動物学会関東支部第71回大会
• [Presentation] 高齢者におけるメラトニン代謝産物AMKの記憶力増強作用 (2019)
  • Author(s): 丸山雄介, 岩下洸, 服部淳彦
  • Organizer: 第38回日本認知症学会学術集会
• [Presentation] 老齢マウスを用いたメラトニン代謝産物AMKによる学習記憶能力の改善効果 (2019)
  • Author(s): 岩下洸, 丸山雄介, 渡辺数基, 千葉篤彦, 服部淳彦
  • Organizer: 第38回日本認知症学会学術集会
• [Presentation] メラトニンは宇宙空間で引きこされる骨吸収を抑制する治療薬になる可能性がある． (2019)
  • Author(s): 鈴木信雄，池亀美華，田渕圭章，古澤之裕，北村敬一郎，関口俊男，山本 樹，矢野幸子，平山 順，服部淳彦
  • Organizer: 日本宇宙生物科学会第33回大会
• [Presentation] アカエイ（Dasyatis akajei）カルシトニンにおける生殖腺調節機能の解析 (2019)
  • Author(s): 関口俊男，高木貴志，笹山雄一，服部淳彦，渡邊卓司，木谷洋一郎，田渕圭章，松原 創，鈴木信雄
  • Organizer: 第44回日本比較内分泌学会
• [Presentation] 宇宙空間で引き起こされる骨吸収を抑制する治療薬（メラトニン）の作用 (2019)
  • Author(s): 鈴木信雄，池亀美華，田渕圭章，古澤之裕，北村敬一郎、関口俊男，山本 樹，矢野幸子，平山 順、服部淳彦
  • Organizer: 令和元年度日本動物学会中部支部大会
• [Presentation] キンギョの骨芽細胞及び破骨細胞に対するスタニウス小体抽出物の作用 (2019)
  • Author(s): 鈴木晶子，関口俊男，服部淳彦，Srivastav A.K.，鈴木信雄
  • Organizer: 令和元年度日本動物学会中部支部大会
• [Presentation] アカテガニの生態学的研究 (2019)
  • Author(s): 村山寛記，小木曽正造，岡村隆行，柳井清治，関本愛香，丸山雄介，服部淳彦，鈴木信雄
  • Organizer: 令和元年度日本動物学会中部支部大会
• [Presentation] ゼブラフィッシュ鱗における骨芽細胞由来の細胞外小胞の取り込みは破骨細胞の分化を促進する. (2019)
  • Author(s): 小林静静，山森汐莉，近藤真央，黒田純平，池亀美華，鈴木信雄，服部淳彦，北村敬一郎，山口正晃，小林 功
  • Organizer: 令和元年度日本動物学会中部支部大会
• [Presentation] Influence of melatonin on bone metabolism in aged mice. (2019)
  • Author(s): Migitaka, J., Seki, A., Hattori, A. and Suzuki, N.
  • Organizer: Joint International Symposium on Sustainable Development and Environmental issues
  • Int'l Joint Research
• [Presentation] メラトニン研究の最新情報 (2019)
  • Author(s): 服部淳彦
  • Organizer: 日本抗加齢医学会2018年度 第4回メディアセミナー
  • Invited
• [Presentation] メラトニン(MEL)はキンギョの脳における糖の取込みを促進する (2019)
  • Author(s): 岡田玲那, 渡辺数基, 丸山雄介, 服部淳彦
  • Organizer: 日本動物学会関東支部第71回大会
• [Presentation] 長期記憶誘導作用を持つメラトニンの脳内代謝産物AMK (2018)
  • Author(s): 服部淳彦
  • Organizer: 第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会 合同年会
  • Invited
• [Presentation] メラトニンと睡眠・抗加齢効果 (2018)
  • Author(s): 服部淳彦
  • Organizer: 日本抗加齢協会セミナー
  • Invited
• [Presentation] ゼブラフィッシュ鱗を用いた骨折修復過程におけるライブイメージング解析 (2018)
  • Author(s): 小林静静, 近藤真央, 山森汐莉, 鈴木信雄, 服部淳彦, 北村敬一郎, 山口正晃, 小林功
  • Organizer: 日本分子生物学会第41回年会
• [Presentation] α-MSH は血漿カルシトニン濃度を上昇させてカルシウム代謝に関与する (2018)
  • Author(s): 鈴木信雄, 五十里雄大, 小林勇喜, 水澤寛太, 高橋明義, 木谷洋一郎, 関口俊男, 遠藤雅人,神戸川明, 朝比奈潔, 田渕圭章, Thumronk Amornsakun, 服部淳彦
  • Organizer: 第43回日本比較内分泌学会大会及びシンポジウム
• [Presentation] マウスの長期記憶形成に関与する内因性のメラトニン代謝産物 N-acetly-5-methoxykynuramine (AMK) (2018)
  • Author(s): 岩下洸, 丸山雄介, 張賢, 松本幸久, 千葉篤彦, 服部淳彦
  • Organizer: 第43回日本比較内分泌学会大会及びシンポジウム
• [Presentation] 夜間のメラトニンはインスリンを介さずにキンギョの糖代謝を調節している (2018)
  • Author(s): 渡辺数基, 中野真樹, 丸山雄介, 服部淳彦
  • Organizer: 第43回日本比較内分泌学会大会及びシンポジウム
• [Presentation] Effects of low-intensity pulsed ultrasound on osteoclastogenesis with goldfish scales having both osteoclasts and osteoblasts. (2018)
  • Author(s): Nobuo Suzuki，Taizo Hanmoto, Yoshiaki Tabuchi, Sachiko Yano, Mika Ikegame, Kei-ichiro Kitamura, Toshio Sekiguchi, Isao Kobayashi, Azusa Seki and Atsuhiko Hattori
  • Organizer: 日本宇宙生物科学会第32回大会
• [Presentation] マウスにおける内因性のメラトニン代謝産物N-acetly-5-methoxykynuramine (AMK)と長期記憶形成との関連 (2018)
  • Author(s): 岩下洸，丸山雄介，張賢，松本幸久，千葉篤彦，服部淳彦
  • Organizer: 第29回日本行動神経内分泌研究会
• [Presentation] メラトニンMT1/MT2受容体アゴニストによる学習記憶機能の増強作用 (2018)
  • Author(s): 佐野真広、岩下洸、梅木智裕、中村華子、吉川史紘、服部淳彦、千葉篤彦
  • Organizer: 第29 回 日本行動神経内分泌研究会
• [Presentation] アルツハイマー様の学習記憶障害を示すマウスに対するメラトニンの学習記憶機能の改善効果 (2018)
  • Author(s): 梅木智裕、岩下洸、佐野真広、中村華子、吉川史紘、服部淳彦、千葉篤彦
  • Organizer: 第29 回 日本行動神経内分泌研究会
• [Presentation] 骨粗鬆症モデルラットにおける副甲状腺ホルモンとメラトニンの併用効果 (2018)
  • Author(s): 池亀美華、田中みか子、江尻貞一、服部淳彦、高尾亮子、内部健太、岡村裕彦
  • Organizer: 第60回歯科基礎医学会総会
• [Presentation] 赤外・ラマン分光による硬骨魚ウロコの構造解析 (2018)
  • Author(s): 奈良雅之、丸山雄介、服部淳彦
  • Organizer: 第27回バイオイメージング学会学術集会
• [Presentation] 「学習・記憶」－加齢性記憶障害の回復作用 (2018)
  • Author(s): 服部淳彦
  • Organizer: 第10回抗加齢内分泌研究会
  • Invited
• [Presentation] Melatonin, the hormone of gloom: Implications in the semilunar-synchronized spawning of the grass puffer. (2018)
  • Author(s): Hironori Ando, Md. Shahjahan, Takashi Kitahashi and Atsuhiko Hattori
  • Organizer: AOSCE2018
  • Int'l Joint Research
• [Presentation] 内因性のメラトニン代謝産物N-acetyl-5-methoxykyuramine(AMK)による長期記憶誘導作用 (2018)
  • Author(s): 岩下光, 松本幸久, 丸山雄介, 張賢, 千葉篤彦, 服部淳彦
  • Organizer: 第18回日本抗加齢医学会総会
• [Book] 動物の事典 第9章 動物のホルモンとホメオスタシス (2020)
  • Author(s): 服部淳彦(分担)
  • Total Pages: 60
  • Publisher: 朝倉書店
• [Book] "Toxicities of polycyclic aromatic hydrocarbons in fish and marine invertebrates." in Polycyclic Aromatic Hydrocarbons (2018)
  • Author(s): Suzuki, N., Ikari, T., Sato, M., Toriba, A., Sekiguchi, T., Kitani, Y., Ogiso, S., Yachiguchi, K., Hattori, A., Oshima, Y. and Hayakawa, K.
  • Total Pages: 15
  • Publisher: Springer