| Project/Area Number |
18K11666
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 63040:Environmental impact assessment-related
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| Research Institution | Osaka University (2022)
Kyoto Prefectural University of Medicine (2021)
National Cardiovascular Center Research Institute (2019-2020)
Kyushu University (2018) |
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Principal Investigator |
Onozuka Daisuke 大阪大学, 大学院医学系研究科, 特任准教授(常勤) (50446829)
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| Co-Investigator(Kenkyū-buntansha) |
萩原 明人 九州大学, 医学研究院, 教授 (50291521)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 環境疫学 / 環境保健学 / 気候変動 / 異常気象 / 感染症疫学 / 救急疫学 / 公衆衛生学 / 予防医学 / 脆弱性 / 効果修飾 / 相互作用 / 感染症 / 救急搬送 / 病院外心肺停止 |
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| Outline of Final Research Achievements |
After adjusting for confounding factors such as climate change and effect modifiers, on days of Japan Series matches, the pooled relative risk of OHCA was 1.033 (95% confidence interval 1.012 to 1.055; p = 0.002; I2 = 3.5%, P for heterogeneity = 0.405). Stratified analyses by gender revealed that the substantial increase in OHCA during the events was observed for men, whereas we found no significant increase for women. The overall cumulative relative risk of OHCA versus the MMP was 1.25 (95% confidence interval, 1.16-1.34) for extreme influenza epidemics (at the 99th percentile of influenza incidence). The effect of extreme influenza epidemics was significant for lag periods of 1.5-7.1 and 17.9-21 days. On days with a full moon, the pooled adjusted relative risk (RR) of emergency transport due to traffic accidents was 1.042 (95% confidence interval [CI], 1.021-1.063). Overall, 4.03% (95% CI: 2.06-5.93) of the cases (1192 cases) were attributable to full moon nights.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の結果、気候変動や効果修飾因子の影響を考慮した上でも、重度の心的ストレスに関連する院外心停止の予防対策については、特に高齢の男性に対して実施すべきであることが示唆された。また、院外心停止のリスクを減らすためには、インフルエンザの流行に対して数週間の予防策を実施すべきであることが示唆された。さらに、交通事故による救急搬送を減らすためには、公衆衛生対策の一つとして満月の夜について考慮すべきであることが示唆された。
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