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Biomechanics of collective sperm swimming as active matter and its application to analysis of morphological evolution

Research Project

Project/Area Number 18K12052
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 90110:Biomedical engineering-related
Research InstitutionYokohama National University

Principal Investigator

Hyakutake Toru  横浜国立大学, 大学院工学研究院, 教授 (20335582)

Co-Investigator(Kenkyū-buntansha) 安井 学  地方独立行政法人神奈川県立産業技術総合研究所, 電子技術部, 主任研究員 (80426361)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords精子遊泳 / 走流性 / 走触性 / マイクロ流体チップ / 集団遊泳 / 粘弾性流体 / 哺乳類精子 / マイクロ流体デバイス / 精子選別 / アクティブマター
Outline of Final Research Achievements

In order to elucidate the swimming mechanism of mammalian sperm that fertilize in a special fluid environment such as the oviduct, we investigated sperm swimming characteristics in several environments using soft lithography-based microfluidic devices. (1) investigation of sperm motility characteristics in microfluidic channels with groove, (2) study on microfluidic chips with tapered sperm accumulation structures in the channels, and (3) observation of collective sperm swimming in a shear thinning viscoelastic fluid.

Academic Significance and Societal Importance of the Research Achievements

これらの研究で得られた結果は,学術的意義としては,哺乳類精子が体内受精において卵子に到達する過程に関する新しい知見を提供できる.社会的意義としては,精子の体内受精プロセスを理解することで、生殖補助医療や畜産分野において,体外受精への適用を想定した高受胎性を有するマイクロ流体チップを開発する上での重要な知見を提供できる.

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (13 results)

All 2021 2020 2019 2018

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Particle Behavior in Curved Microchannels: Aspect Ratio Effects2021

    • Author(s)
      Hayamizu Y、Nakamura A、Hyakutake T、Gonda T、Morita S、Ohtsuka S、Yanase S
    • Journal Title

      Journal of Physics: Conference Series

      Volume: 1909 Issue: 1 Pages: 012062-012062

    • DOI

      10.1088/1742-6596/1909/1/012062

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Experimental study on the effect of flow in microfluidic channel on bovine sperm navigation2021

    • Author(s)
      Toru Hyakutake, Kenta Sugita, Shota Ujifuku, Rintaro Sakurai, Renta Murakami and Yasutaka Hayamizu
    • Journal Title

      Journal of Biomechanics

      Volume: 118 Pages: 110290-110290

    • DOI

      10.1016/j.jbiomech.2021.110290

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 受精環境下における牛精子の運動特性2020

    • Author(s)
      (55)百武徹
    • Journal Title

      ながれ

      Volume: 40 Pages: 8-13

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Study of bovine sperm motility in shear-thinning viscoelastic fluids2019

    • Author(s)
      Toru Hyakutake, Koichi Sato and Kenta Sugita
    • Journal Title

      Journal of Biomechanics

      Volume: 88 Pages: 130-137

    • DOI

      10.1016/j.jbiomech.2019.03.035

    • NAID

      120006646729

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of surrounding fluid on motility of hyperactivated bovine sperm2018

    • Author(s)
      Hyakutake Toru、Mori Kotaro、Sato Koichi
    • Journal Title

      Journal of Biomechanics

      Volume: 71 Pages: 183-189

    • DOI

      10.1016/j.jbiomech.2018.02.009

    • NAID

      120006646731

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 溝付きマイクロチャネル内の精子の挙動2021

    • Author(s)
      坂本 虎之介,早水 庸隆 ,白石 僚也,大塚 茂,森田 慎一,百武 徹
    • Organizer
      日本機械学会第99期流体工学部門講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] マイクロチャネル内の精子の挙動(運動精子に及ぼす溝の影響)2021

    • Author(s)
      坂本 虎之介,早水 庸隆 ,白石 僚也,大塚 茂,森田 慎一,百武 徹
    • Organizer
      日本機械学会中国四国支部第60期総会・講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 溝付きマイクロ流路内における精子運動特性の調査2020

    • Author(s)
      氏福 祥太, 瀬戸 佑菜, 百武 徹
    • Organizer
      第31回バイオフロンティア講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] Particle Behavior in Curved Microchannels: Aspect Ratio Effects2020

    • Author(s)
      Y. Hayamizu, A. Nakamura, T. Hyakutake, T. Gonda, S. Morita, S. Ohtsuka, and S. Yanase
    • Organizer
      ISROMAC2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] マイクロ流体チップを用いたウシ精子の 運動性評価2019

    • Author(s)
      杉田 健太, 氏福 祥太, 櫻井 凛太 郎, 村上 蓮太, 安井 学, 三田 正弘, 百武 徹
    • Organizer
      第32回バイオエンジニアリング講演会
    • Related Report
      2019 Research-status Report
  • [Presentation] Study on effect of surrounding fluid property on sperm motility2018

    • Author(s)
      Toru Hyakutake
    • Organizer
      World Congress on Medical Pysics & Biomedical Engineering
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Study on effect of surrounding fluid property on sperm motility2018

    • Author(s)
      Toru Hyakutake
    • Organizer
      8th World Congress of Biomechanics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] 運動性精子選別チップ及びその方法2020

    • Inventor(s)
      三田正弘,安井学,百武徹
    • Industrial Property Rights Holder
      三田正弘,安井学,百武徹
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2020 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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