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Elucidation of the pathophysiology of autism spectrum disorder by evaluating biological rhythms during the fetal and neonatal period

Research Project

Project/Area Number 18K13108
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 09030:Childhood and nursery/pre-school education-related
Research InstitutionUniversity of Fukui

Principal Investigator

Takuya Kosaka  福井大学, 学術研究院医学系部門(附属病院部), 特命助教 (90792101)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords自閉スペクトラム症 / 睡眠障害 / 発達障害
Outline of Final Research Achievements

We conducted a study on the actual condition of sleep disorders in children with autism spectrum disorder (ASD), which is the study plan B. A total of 40 children participated in this study (n = 20, with ASD and n = 20, age-matched children with typical development. We examined sleep dynamics using actigraph for 7 consecutive days, and the relationship between sleep parameters and sensory characteristics was analyzed using the Japanese Version of Sensory Profile(SP-J). In the ASD group, significant positive correlations were observed between activities per minute during sleep and low thresholds for Vestibular Sensory stimuli and Oral Sensory stimuli using the SP-J. Based on a multiple regression analysis, the activities per minute during sleep were associated with low thresholds for Oral Sensory stimuli in the ASD group.

Academic Significance and Societal Importance of the Research Achievements

ASDの原因や病態は未だ不明な点が多く、行動特性の改善につながる有効な介入法は乏しいことが現状である。本研究結果から、ASD児の睡眠障害の原因としての感覚特性の観点から、新生児期、乳児期を含めた睡眠障害、感覚特性がみられる児に対する発達のフォローアップ、早期の診断評価、また支援につながる可能性が考えられた。感覚特性への積極的な介入がASD児の睡眠の質、さらには認知機能や実行機能の改善が得られるかが今後の研究課題である。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2021 2020 2019 2018

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (7 results)

  • [Journal Article] Low threshold to Vestibular and Oral Sensory stimuli might affect quality of sleep among children with autism spectrum disorder2021

    • Author(s)
      Kosaka Takuya、Kawatani Masao、Ohta Genrei、Mizuno Yoshifumi、Takiguchi Shinichiro、Kumano Asami、Hayashi Hisako、Fujine Akio、Tsuda Akemi、Fujisawa Takashi X.、Tomoda Akemi、Ohshima Yusei
    • Journal Title

      Brain and Development

      Volume: 43 Issue: 1 Pages: 55-62

    • DOI

      10.1016/j.braindev.2020.07.010

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 神経発達症に伴う睡眠障害に対するラメルテオンとメラトニンの効果検証2021

    • Author(s)
      小坂拓也、平谷美智夫、前田夢吉、巨田元礼、 滝口慎一郎、川谷正男、大嶋勇成
    • Organizer
      第63回日本小児神経学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 福井県における発達支援体制改革への取り組み:第2報2021

    • Author(s)
      小坂拓也、福井県小児科医会子どものこころ医療委員会地域支援班
    • Organizer
      日本小児神経学会北陸地方会夏季セミナー(第 11 回白山セミナー)
    • Related Report
      2021 Annual Research Report
  • [Presentation] 自閉スペクトラム症児におけるアクチグラフにより計測した睡眠動態と感覚特性との関連2020

    • Author(s)
      小坂拓也、熊野麻美、林仁幸子、巨田元礼、滝口慎一郎、冨士根明雄、川谷正男、津田明美、友田明美、大嶋勇成
    • Organizer
      第62回日本小児神経学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] アクチグラフによる幼児期の自閉スペクトラム症児と定型発達児の睡眠動態の比較2019

    • Author(s)
      小坂拓也、巨田元礼、滝口慎一郎、川谷正男、大嶋勇成、友田明美
    • Organizer
      第122回小児精神神経学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 発達障害児の睡眠障害に対する年齢と睡眠型によるラメルテオンの有効性の検討2019

    • Author(s)
      小坂 拓也
    • Organizer
      第122回日本小児科学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 幼児期の発達障害児に対するラメルテオンの目標内服時刻と内服による入眠時刻の改善度の検討2019

    • Author(s)
      小坂 拓也
    • Organizer
      第61回日本小児神経学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 幼児期における発達障害児の睡眠障害に対するラメルテオンの有効性の検討2018

    • Author(s)
      小坂 拓也
    • Organizer
      第60回日本小児神経学会学術集会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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