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A new high altitude adaptation model constructed from whole genome analysis and physiological information

Research Project

Project/Area Number 18K14808
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 45060:Applied anthropology-related
Research InstitutionKyushu University (2019-2021)
Nagasaki University (2018)

Principal Investigator

Nishimura Takayuki  九州大学, 芸術工学研究院, 講師 (80713148)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords高地適応 / 生理的多型 / 遺伝的多型 / 遺伝子多型
Outline of Final Research Achievements

High-altitude adaptation studies have focused on low-hemoglobin-type adaptation by specific mutations in the EPAS1 gene in the Tibetan population, but few studies have focused on diversity within the population. Therefore, in this study, we performed physiological measurements of Tibetan and Andean populations by field research, and clarified various factors (gender, age, genetic background) related to their physiological variations.

Academic Significance and Societal Importance of the Research Achievements

人類の繁栄には、様々な環境に対して柔軟に適応できる高い環境適応能が重要な役割を果たしてきた。本研究はその中でも、高地集団における適応能の多様性に注目したところ、これまではチベット型適応、アンデス型適応と一括りにされがちであった適応様式だが、実際には多様であることがわかった。人類は特徴的な高地集団でも多様であり、その適応能の多様性と我々のような低地集団の共通性の理解が、高山病のリスクや生体内の低酸素状態に起因する健康問題の低減に繋がる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (15 results)

All 2022 2021 2020 2019 2018

All Journal Article (10 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 10 results,  Open Access: 10 results) Presentation (4 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Individual variations and sex differences in hemodynamics and percutaneous arterial oxygen saturation (SpO2) in Tibetan highlanders of Tsarang in the Mustang district of Nepal2022

    • Author(s)
      Nishimura Takayuki、Arima Hiroaki、Koirala Sweta、Ito Hiromu、Yamamoto Taro
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 41 Issue: 1 Pages: 9-9

    • DOI

      10.1186/s40101-022-00282-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between vitamin D and bone mineral density in Japanese adults: the Unzen study2021

    • Author(s)
      Honda Yuzo、Arima Kazuhiko、Nishimura Takayuki、Tomita Yoshihito、Mizukami Satoshi、Abe Yasuyo、Tanaka Natsumi、Kojima Michiko、Jeng Tsung-Ping、Goto Hisashi、Hasegawa Maiko、Sou Youko、Tsujimoto Ritsu、Kanagae Mitsuo、Osaki Makoto、Aoyagi Kiyoshi
    • Journal Title

      Archives of Osteoporosis

      Volume: 16 Issue: 1 Pages: 127-127

    • DOI

      10.1007/s11657-021-00984-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Individual variations and sex differences in hemodynamics with percutaneous arterial oxygen saturation (SpO<sub>2</sub>) in young Andean highlanders in Bolivia2020

    • Author(s)
      Nishimura Takayuki、Ugarte Juan、Ohnishi Mayumi、Nishihara Mika、Alvarez Guillermo、Yasukochi Yoshiki、Fukuda Hideki、Arima Kazuhiko、Watanuki Shigeki、Mendoza Victor、Aoyagi Kiyoshi
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 39 Issue: 1 Pages: 31-31

    • DOI

      10.1186/s40101-020-00240-y

    • NAID

      120006988493

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of EGLN1 Genetic Polymorphisms on Hemoglobin Concentration in Andean Highlanders2020

    • Author(s)
      Yasukochi Yoshiki、Nishimura Takayuki、Ugarte Juan、Ohnishi Mayumi、Nishihara Mika、Alvarez Guillermo、Fukuda Hideki、Mendoza Victor、Aoyagi Kiyoshi
    • Journal Title

      BioMed Research International

      Volume: 2020 Issue: 1 Pages: 1-16

    • DOI

      10.1155/2020/3436581

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Vitamin K deficiency, evaluated with higher serum ucOC, was correlated with poor bone status in women2020

    • Author(s)
      Tanaka Natsumi、Arima Kazuhiko、Nishimura Takayuki、Tomita Yoshihito、Mizukami Satoshi、Okabe Takuhiro、Abe Yasuyo、Kawashiri Shin-ya、Uchiyama Michiko、Honda Yuzo、Tsujimoto Ritsu、Kanagae Mitsuo、Osaki Makoto、Aoyagi Kiyoshi
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 39 Issue: 1 Pages: 9-9

    • DOI

      10.1186/s40101-020-00221-1

    • NAID

      120006988233

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Implications of human activities for (re)emerging infectious diseases, including COVID-192020

    • Author(s)
      Sabin Nundu Sabiti、Calliope Akintije Simba、Simpson Shirley Victoria、Arima Hiroaki、Ito Hiromu、Nishimura Takayuki、Yamamoto Taro
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 39 Issue: 1 Pages: 29-29

    • DOI

      10.1186/s40101-020-00239-5

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] THE RELATIONSHIP BETWEEN HUMAN COLD ADAPTATION AND UCP1 GENOTYPE.2019

    • Author(s)
      西村 貴孝
    • Journal Title

      Japanese Journal of Physiological Anthropology

      Volume: 24 Issue: 2 Pages: 81-85

    • DOI

      10.20718/jjpa.24.2_81

    • NAID

      130007677030

    • ISSN
      1342-3215, 2432-0986
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of EGLN1 genetic polymorphisms with SpO2 responses to acute hypobaric hypoxia in a Japanese cohort2018

    • Author(s)
      Yasukochi Yoshiki、Nishimura Takayuki、Motoi Midori、Watanuki Shigeki
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 37 Issue: 1 Pages: 9-9

    • DOI

      10.1186/s40101-018-0169-7

    • NAID

      120006987329

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Current health status and its risk factors of the Tsarang villagers living at high altitude in the Mustang district of Nepal2018

    • Author(s)
      Koirala Sweta、Nakano Masayuki、Arima Hiroaki、Takeuchi Shouhei、Ichikawa Tomo、Nishimura Takayuki、Ito Hiromu、Pandey Basu Dev、Pandey Kishor、Wada Takayuki、Yamamoto Taro
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 37 Issue: 1 Pages: 20-20

    • DOI

      10.1186/s40101-018-0181-y

    • NAID

      120006987944

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ADAPTATION TO THERMAL ENVIRONMENT – LIFESTYLE MODIFICATION AFFECTING HUMAN ADAPTABILITY TO THERMAL ENVIRONMENT –2018

    • Author(s)
      若林 斉、前田 享史、西村 貴孝
    • Journal Title

      Japanese Journal of Physiological Anthropology

      Volume: 23 Issue: 4 Pages: 167-170

    • DOI

      10.20718/jjpa.23.4_167

    • NAID

      130007580264

    • ISSN
      1342-3215, 2432-0986
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Individual and sex differences of percutaneous arterial oxygen saturation (SpO2) in Bolivian people2019

    • Author(s)
      Nishimura T, Ohnishi M, Nishihara M, Ugarute J, Yasukochi Y, Fukuda H, Watanuki S, Aoyagi K
    • Organizer
      The 14th International Congress of Physiological Anthropology.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ヒトの寒冷適応とUCP1遺伝子多型との関連2018

    • Author(s)
      西村 貴孝
    • Organizer
      日本生理人類学会第78回大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Human cold adaptation and importance of UCP1 genotype to non-shivering thermogenesis2018

    • Author(s)
      Takayuki Nishimura
    • Organizer
      Physiological Anthropology and Human Ecology: Studies in Modern and Ancient Populations
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ボリビア高地集団における循環動態の高度差による影響2018

    • Author(s)
      西村貴孝,大西真由美,西原三佳,Juan Ugarte,安河内彦輝,福田英輝,安部恵代,有馬和彦,富田義人,本井 碧,綿貫茂喜,青柳 潔
    • Organizer
      日本生理人類学会第77回大会
    • Related Report
      2018 Research-status Report
  • [Book] 人間の本質にせまる科学2021

    • Author(s)
      井原 泰雄、梅﨑 昌裕、米田 穣(編)西村 貴孝(著)
    • Total Pages
      296
    • Publisher
      東京大学出版会
    • ISBN
      4130622285
    • Related Report
      2020 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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