A new high altitude adaptation model constructed from whole genome analysis and physiological information
| Project/Area Number |
18K14808
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 45060:Applied anthropology-related
|
|---|
| Research Institution | Kyushu University (2019-2021)
Nagasaki University (2018) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2018-04-01 – 2022-03-31
|
| Project Status |
Completed (Fiscal Year 2021)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 高地適応 / 生理的多型 / 遺伝的多型 / 遺伝子多型 |
|---|
| Outline of Final Research Achievements |
High-altitude adaptation studies have focused on low-hemoglobin-type adaptation by specific mutations in the EPAS1 gene in the Tibetan population, but few studies have focused on diversity within the population. Therefore, in this study, we performed physiological measurements of Tibetan and Andean populations by field research, and clarified various factors (gender, age, genetic background) related to their physiological variations.
|
| Academic Significance and Societal Importance of the Research Achievements |
人類の繁栄には、様々な環境に対して柔軟に適応できる高い環境適応能が重要な役割を果たしてきた。本研究はその中でも、高地集団における適応能の多様性に注目したところ、これまではチベット型適応、アンデス型適応と一括りにされがちであった適応様式だが、実際には多様であることがわかった。人類は特徴的な高地集団でも多様であり、その適応能の多様性と我々のような低地集団の共通性の理解が、高山病のリスクや生体内の低酸素状態に起因する健康問題の低減に繋がる。
|
Report
(5 results)
Research Products
(15 results)
