| Project/Area Number |
18K14934
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 47050:Environmental and natural pharmaceutical resources-related
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
Abe Naohito 岐阜薬科大学, 薬学部, 講師 (70725754)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | パイオプロスペクティング / 天然物化学 / カヤツリグサ科植物 / 化学多様性 / バイオプロスペクティング / 動脈硬化 / 抗炎症作用 / 新規機能性分子 / 動脈硬化症 |
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| Outline of Final Research Achievements |
This study is the first of its kind in recent years in Japan. The subject of this study, Cyperaceae, is a plant resource that grows wild in many parts of Japan. In spite of their existence, only a few cases of component studies have been completed. In addition, this family of plants is an underutilized plant resource that has a lot of scope for molecular phylogenetic studies in plant taxonomy. In this study, the chemical constituents of the Cyperaceae plants collected from various parts of Japan were studied in detail to identify the rare and novel The structure of the compounds and the analysis of the contained compounds provided basic insights into phytochemical classification. From the results of bioactivity tests, it was found that compounds with rare structures have specific bioactivity.
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| Academic Significance and Societal Importance of the Research Achievements |
カヤツリグサ科植物群は約0.2％しか研究対象になっていない未利用資源である．本科植物の化学多様性を明らかにすることは，今後の生物活性試験への応用に対する基盤研究となるとともに植物分類学への一助となる．さらに，本科植物の生物活性試験に関する研究は，本科唯一の生薬「香附子」の研究を除くと皆無に等しい． 本研究において、カヤツリグサ科植物を化学成分の解明を目的に約15属128種を収集し、鹿児島県種子島において新たに9属32種の本科植物を収集することで、本科植物に含まれる基礎的化学成分が明らかとなったことから、今後さまざまな薬理活性試験に利用され，有用な生理活性を見出すことが期待できる．
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