A new treatment strategy for malignant glioma using spatially fractionated GRID radiation therapy

• Project/Area Number: 18K15279
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50020:Tumor diagnostics and therapeutics-related
• Research Institution: Kobe University
• Principal Investigator: Ishihara Takeaki 神戸大学, 医学部附属病院, 助教 (10546477)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 新規放射線治療 / グリッド照射 / 放射線治療 / 脳腫瘍 / 放射線腫瘍学 / 抗腫瘍効果

Outline of Final Research Achievements

This study was started with the aim of developing a new treatment using Grid. We created a size for a human. Based on information obtained from past literature and overseas conference, the size of holes, the distance between holes, the number of holes on the surface of the grid, the arrangement of holes, etc. were plotted. Based on this information, a metal processing contractor created a grid of a size that can be actually irradiated to people by using a lead material.
Next, it was necessary to confirm that the X-rays would pass through this grid correctly, so irradiation experiments using films were performed. The irradiation film analysis confirmed that the expected doses of valley dose and peak dose were expressed, and that irradiation was possible. In addition, the same experiment was performed by changing the energy or changing the electron beam and X-ray source, and it was confirmed that they passed through this hole without any problem.

Academic Significance and Societal Importance of the Research Achievements

この人間用Gridの作成が完成し、そのGridが照射実験にて、予測通りのValley doseとPeak doseを表現できることが確認できたことにより、次に動物実験に移ることが可能である。当初はマウスを予定していたが、マウスサイズのグリッド作成は著しく困難であり、今後は豚に悪性神経膠腫細胞を埋植した上で、照射実験を行うことを考える。この実験により、このグリッド照射が現在治癒がほぼ不可能な悪性神経膠腫に対して、大量の放射線を照射することで重篤な有害事象を起こすことなく制御できることを期待できる画期的な治療になる。

Research Products

• [Journal Article] Amelioration of Radiation Enteropathy by Dietary Supplementation With Reduced Coenzyme Q10 (2019)
  • Author(s): Shimizu Yasuyuki、Mukumoto Naritoshi、Idrus Nelly、Akasaka Hiroaki、Inubushi Sachiko、Yoshida Kenji、Miyawaki Daisuke、Ishihara Takeaki、Okamoto Yoshiaki、Yasuda Takahiro、Nakahana Makiko、Sasaki Ryohei
  • Journal Title: Advances in Radiation Oncology Volume: 4 Issue: 2 Pages: 237-245
  • DOI: 10.1016/j.adro.2019.01.006
  • NAID: 120006811120
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Stereotactic body radiotherapy for second primary lung cancer and intra-parenchymal lung metastasis in patients previously treated with surgery: evaluation of indications and predictors of decreased respiratory function (2018)
  • Author(s): Ishihara Takeaki、Yamada Kazunari、Harada Aya、Yukiue Haruhiro、Tanahashi Masayuki、Niwa Hiroshi、Matsui Takashi、Yokomura Koshi、Ejima Yasuo、Sasaki Ryohei
  • Journal Title: Acta Oncologica Volume: 57 Issue: 9 Pages: 1232-1239
  • DOI: 10.1080/0284186x.2018.1468088
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Comparison of dosimetric parameters in the treatment planning of magnetic resonance imaging-based intracavitary image-guided adaptive brachytherapy with and without optimization using the central shielding technique. (2018)
  • Author(s): Nishikawa R, Yoshida K, Ebina Y, Omoteda M, Miyawaki D, Ishihara T, Ejima Y, Akasaka H, Satoh H, Kyotani K, Takahashi S, Sasaki R.
  • Journal Title: Journal of Radiation Research Volume: 印刷中 Issue: 3 Pages: 316-326
  • DOI: 10.1093/jrr/rry009
  • NAID: 120006477549
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Investigation of recurrence factors in pediatric patients who received radiotherapy for ependymoma: A retrospective multicenter analysis conducted by the Japan Children’s Cancer Group. (2019)
  • Author(s): Takeaki Ishihara, Toshinori Soejima, Katsuya Maebayashi, Tetsuya Yamamoto, Hidehiro Kohzuki, Keiko Okada, Junichi Hara, Ryo Nishikawa, and the Japan Children’s Cancer Group.
  • Organizer: 2019 ASTRO annual meeting
  • Int'l Joint Research
• [Presentation] 稀な松果体乳頭状腫瘍に対して放射線治療を施行した症例 (2019)
  • Author(s): Miho Tachibana, Takeaki Ishihara*, Kaori Sasaki*, Satoshi Seno*, Hikaru Kubota*, Yuko Inoue*, Hiroki Kawaguchi*, Ryo Nishikawa*, Daisuke Miyawaki*, Kenji Yoshida*, Ryohei Sasaki*, Kazuhiro Tanaka, Takashi Sasayama
  • Organizer: 第321回公益社団日本医学放射線学会関西地方会(第391回レントゲンアーベント)
• [Presentation] 木村氏病３例に対する放射線治療の経験 (2018)
  • Author(s): Satoshi Seno*, Daisuke Miyawaki*, Kenji Yoshida*, Takeaki Ishihara*, Ryo Nishikawa*, Yuko Inoue*, Hikaru Kubota*, Kaori Sasaki*, Ryohei Sasaki*
  • Organizer: 第319回公益社団日本医学放射線学会関西地方会(第391回レントゲンアーベント)
• [Presentation] 非小細胞肺癌の転移性脳腫瘍に対する定位照射に関する検討 (2018)
  • Author(s): Hiroki Kawaguchi*, Hiroshi Mayahara, Takeaki Ishihara*, Ryohei Sasaki*
  • Organizer: 第59回日本肺癌学会
• [Presentation] Application of dual-energy CT to suppression of metal artifacts caused by spinal implant in radiotherapy (2018)
  • Author(s): Tianyuan Wang*, Takeaki Ishihara*, Atsushi Kono, Naoki Yoshida, Noriyuki Negi, Kenichiro Kakutani, Hiroaki Akasaka*, Ryuichi Yada*, Naritoshi Mukumoto*, Daisuke Miyawaki*, Kenji Yoshida*, Ryohei Sasaki*
  • Organizer: World Congress on Medical Physics and Biomedical Engineering 2018
  • Int'l Joint Research
• [Presentation] Experience of Neoadjuvant Chemoradiotherapy for locally advanced rectal cancer (2018)
  • Author(s): Yuko Inoue*, Kenji Yoshida*, Daisuek Miyawaki*, Takeaki Ishihara*, Ryo Nishikawa*, Satoshi Seno*, Yoshihiro Kakeji, Ryohei Sasaki*
  • Organizer: 第77回日本医学放射線学会総会
• [Presentation] "転移性脳腫瘍に対するサイバーナイフの治療成績及び放射線脳壊死についての検討 " (2018)
  • Author(s): Hiroki Kawaguchi*, Hiroshi Mayahara, Hideki Nishimura*, Aya Harada, Naoki Hashimoto, Keiji Kitatani, Kazuma Iwashita, Kazuyuki Uehara, Takeaki Ishihara*, Ryohei Sasaki*
  • Organizer: 日本放射線腫瘍学会第31回学術大会
• [Presentation] A newly developed bio-degradable fiducial marker for image-guided radiotherapy (2018)
  • Author(s): Tianyuan Wang*, Sachiko Inubushi*, Keisuke Okumura, Kenji Yoshida*, Daisuke Miyawaki*, Takeaki Ishihara*, Naoko Ikeo, Toshiji Mukai and Ryohei Sasaki*
  • Organizer: 日本放射線腫瘍学会第31回学術大会
• [Presentation] 巨大腫瘤を呈した進行外陰癌3例に対する放射線治療の経験 (2018)
  • Author(s): Yuko Inoue*, Kenji Yoshida*, Daisuek Miyawaki*, Takeaki Ishihara*, Ryo Nishikawa*, Hiroki Kawaguchi*, Hikaru Kubota*, Satoshi Seno*, Kaori Sasaki*, Yasuhiko Ebina, Ryohei Sasaki*
  • Organizer: 日本放射線腫瘍学会第31回学術大会
• [Presentation] 当院における悪性脳神経膠腫に対するIMRTの治療成績 (2018)
  • Author(s): Takeaki Ishihara*, Satoshi Seno*, Hiroaki Akasaka*, Naritoshi Mukumoto*, Yuko Inoue*, Ryo Nishikawa*, Daisuke Miyawaki*, Kenji Yoshida*, Ryohei Sasaki*, Takashi Sasayama, Kazuhiro Tanaka
  • Organizer: 日本放射線腫瘍学会第31回学術大会
• [Presentation] 頭頸部扁平上皮癌術後の再発高リスク症例に対する放射線療法の治療成績の検討 (2018)
  • Author(s): Satoshi Seno*, Kenji Yoshida*, Daisuke Miyawaki*, Takeaki Ishihara*, Yoshinobu Imamura, Naomi Kiyota, Hirotaka Shinomiya, Naoki Otsuki, Kenichi Nibu, Ryohei Sasaki*
  • Organizer: 日本放射線腫瘍学会第31回学術大会
• [Presentation] 前立腺癌に対するCTベース画像誘導IMRTにおける金マーカーの有無による治療成績の比較 (2018)
  • Author(s): Hiroshi Mayahara, Hideki Nishimura, Aya Harada, Naoki Hashimoto, Hiroki Kawaguchi, Keiji Kitatani, Kazuma Iwashita, Kazuyuki Uehara, Masao Nakayama, Satoshi Seno, Takeaki Ishihara, Sasaki Ryohei
  • Organizer: 日本放射線腫瘍学会第31回学術大会
• [Presentation] 食道癌に対する根治的治療としてIMRTを含む放射線治療を用いた症例に関する検討 (2018)
  • Author(s): Keiji Kitatani, Hiroshi Mayahara, Hideki Nishimura*, Aya Harada, Naoki Hashimoto, Kazuma Iwashita, Takeaki Ishihara*, Hiroki Kawaguchi*, Satoshi Seno*, Kazuyuki Uehara, Masahiko Fujii, Ryohei Sasaki*
  • Organizer: 日本放射線腫瘍学会第31回学術大会
• [Presentation] 消化管近接型肝細胞癌に対する定位放射線治療の治療成績 (2018)
  • Author(s): Naoki Hashimoto, Hiroshi Mayahara, Hideki Nishimura*, Aya Harada, Hiroki Kawaguchi*, Keiji Kitatani, Kazuma Iwashita, Kazuyuki Uehara, Satoshi Seno*, Takeaki Ishihara*, Ryohei Sasaki*
  • Organizer: 日本放射線腫瘍学会第31回学術大会
• [Presentation] 脊椎転移に対するIMRTの治療成績とFDG-PETによる局所評価 (2018)
  • Author(s): Kazuma Iwashita, Hideki Nishimura*, Hiroshi Mayahara, Aya Harada, Naoki Hashimoto, Hiroki Kawaguchi*, Keiji Kitatani, Kazuyuki Uehara, Takeaki Ishihara*, Masahiko Fujii, Ryohei Sasaki*
  • Organizer: 日本放射線腫瘍学会第31回学術大会
• [Presentation] Treatment outcomes of radiotherapy or chemoradiotherapy for postoperative locoregional recurrence of non-small cell lung cancer. (2018)
  • Author(s): Satoshi Seno*, Kenji Yoshida*, Daisuke Miyawaki*, Takeaki Ishihara*, Ryo Nishikawa*, Yuko Inoue*, Hideki Nishimura*, Yoshiaki Okamoto*, Yoshihiro Nishimura, Ryohei Sasaki*
  • Organizer: ASTRO's 60th Annual Meeting
  • Int'l Joint Research