| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Outline of Final Research Achievements |
How various cells in the human body work is controlled by the genomic information in the cells. The genomic information is not always in a "working state," but various functions are created by combining "working" and "resting" information. The region called chromosome 15q11.2 in the genome is greatly involved in brain functions. In patient-derived iPS cells lacking this region, genomic information in a "resting" state is easily converted to a "working" state on its own. This region seems to control not onle In brain function but also maintenance of the genomic methylation, i.e. "working" and "resting" information. Cells Artificially deleted the region by genome-editing technology are difficult to maintain its survival and this region is considered to be extremely important for iPS cells.
|
