The impact of microRNA-449a on the cancer malignancy such as cancer stemness, epithelial-mesenchymal transition, and glycolysis.
| Project/Area Number |
18K16257
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55010:General surgery and pediatric surgery-related
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ISHIKAWA Daichi 徳島大学, 大学院医歯薬学研究部(医学域), 徳島大学専門研究員 (70633882)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | miR-449a / 大腸癌 / 胃癌 / HDAC1 / 癌幹細胞 / 上皮間葉転換 / 解糖系 / microRNA-449a |
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| Outline of Final Research Achievements |
The significance of microRNA-449a (miR-449a) was investigated in colorectal cancer and gastric cancer. Using the surgically resected specimens (Colorectal cancer: n=72, Gastric cancer: n=66), expressions of miR-449a were evaluated and correlation to clinicopathological factors was examined. The expression of HDAC1 was inversely correlated to miR-449a expression, suggesting the HDAC1 could be the target-gene of miR-449a. The patients with low miR-449a expression had poorer prognosis after surgery. In gastric cancer, the expression of miR-449a was lower in the tumor tissue compared to non-tumor tissue. Serum expression of miR-449a was correlated to the expression of miR-449a in the tumor tissue. The serum expression of miR-449a was lower in the dedifferentiated cancer. miR-449a might be useful for the biomarker in the colorectal and gastric cancer.
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| Academic Significance and Societal Importance of the Research Achievements |
miR-449aの機能・制御機構については不明であったが、今回の研究成果により標的遺伝子HDAC1が同定され、miRNA-449aが大腸癌、胃癌のバイオマーカーとして機能し、さらには術前の血液解析にて癌組織中miR-449a発現が予測可能であることが分かった。miR-449aが新たなバイオマーカーとして利用できることやmiR-449aをターゲットとした新規治療手段開発につながる可能性を示した。
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Usefulness of virtual three-dimensional image analysis in inguinal hernia as an educational tool2019
Author(s)
Wada Y, Nishi M, Yoshikawa K, Higashijima J, Miyatani T, Tokunaga T, Takasu C, Kashihara H, Ishikawa D, Yoshimoto T, Shimada M
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Journal Title
Surg Endosc.
Volume: 34(5)
Issue: 5
Pages: 1923-1928
DOI
Related Report
Peer Reviewed
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[Journal Article] The Outcome of Sorafenib Therapy on Unresectable Hepatocellular Carcinoma: Experience of Conversion and Salvage Hepatectomy2018
Author(s)
Yoshimoto T, Imura S, Morine Y, Ikemoto Y, Arakawa Y, Iwahashi S, Saito YU, Takasu C, Ishikawa D, Teraoku H, Bando Y, Shimada M
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Journal Title
Anticancer Research
Volume: 38
Issue: 1
Pages: 501-507
DOI
Related Report
Peer Reviewed
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