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Glycobiological approach to predicting and preventing the progression of non-muscle invasive bladder cancer

Research Project

Project/Area Number 18K16683
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56030:Urology-related
Research InstitutionTohoku University

Principal Investigator

Shimada Shuichi  東北大学, 大学病院, 助教 (80749218)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords膀胱癌 / 糖脂質 / 化学合成 / 筋層非浸潤性膀胱癌 / DSGb5 / 5F3 / 糖鎖 / 精密定量測定 / 免疫染色 / 糖鎖抗原 / NK 細胞 / 脈管侵襲 / 表在性膀胱癌
Outline of Final Research Achievements

In the current study, we investigated the relationship between DsGb5 expression and clinicopathological characteristics of NMIBC patients.Immunohistochemical staining was performed on 30 patients who underwent transurethral resection of bladder tumor in our university hospital. The expression of DSGb5 tended to increase according to the malignancy, but it was difficult to objectively evaluate it. Therefore, we decided to use patient serum for examination. However, standard substance of DSGb5 were necessary to accurate quantify DSGb5 of tumor. And then we established experimental system of chemical synthesis of DSGb5, at last we were able to synthase DSGb5 chemically to accurate quantify by mass spectrometer.

Academic Significance and Societal Importance of the Research Achievements

DSGb5糖鎖については、私たちの研究室で独自の研究としてこれまで進めて来たものでる。前立腺癌に関する研究はこれまで行われておらず、DSGb5値と膀胱癌の診断および臨床像との関係を調べる本研究を継続することにより患者の病態に応じた適切な治療が提供可能となり、本研究の意義は大きいものと考えられる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (16 results)

All 2021 2020 2019

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (7 results) Book (2 results)

  • [Journal Article] Predictive model for recurrence of renal cell carcinoma by comparing pre‐ and postoperative urinary metabolite concentrations2021

    • Author(s)
      Morozumi Kento、Kawasaki Yoshihide、Maekawa Masamitsu、Takasaki Shinya、Sato Tomonori、Shimada Shuichi、Kawamorita Naoki、Yamashita Shinichi、Mitsuzuka Koji、Mano Nariyasu、Ito Akihiro
    • Journal Title

      Cancer Science

      Volume: 113 Issue: 1 Pages: 182-194

    • DOI

      10.1111/cas.15180

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolomic Analysis to Elucidate Mechanisms of Sunitinib Resistance in Renal Cell Carcinoma2020

    • Author(s)
      Sato T, Kawasaki Y, Maekawa M, Takasaki S, Morozumi K, Sato M, Shimada S, Kawamorita N, Yamashita S, Mitsuzuka K, Mano N, Ito A.
    • Journal Title

      Metabolites

      Volume: 11(1) Issue: 1 Pages: 1-16

    • DOI

      10.3390/metabo11010001

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accurate quantification of urinary metabolites for predictive models manifest clinicopathology of renal cell carcinoma2020

    • Author(s)
      Sato Tomonori、Kawasaki Yoshihide、Maekawa Masamitsu、Takasaki Shinya、Shimada Shuichi、Morozumi Kento、Sato Masahiko、Kawamorita Naoki、Yamashita Shinichi、Mitsuzuka Koji、Mano Nariyasu、Ito Akihiro
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 7 Pages: 2570-2578

    • DOI

      10.1111/cas.14440

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of Ganglioside Disialosyl Globopentaosyl Ceramide in Prostate Biopsy Specimens as a Predictive Marker for Recurrence after Radical Prostatectomy2020

    • Author(s)
      Sato Masahiko、Shimada Shuichi、Watanabe Mika、Kawasaki Yoshihide、Sato Tomonori、Morozumi Kento、Mitsuzuka Koji、Ito Akihiro
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 252 Issue: 1 Pages: 1-8

    • DOI

      10.1620/tjem.252.1

    • NAID

      130007888551

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of cancer therapy on post‐treatment ejaculation disorder and sexual life in testicular cancer survivors2020

    • Author(s)
      Koyama Juntaro、Yamashita Shinichi、Yamada Shigeyuki、Fujii Shinji、Goto Takuro、Katayama Hiromichi、Satake Yohei、Sato Takuma、Shimada Shuichi、Kawasaki Yoshihide、Kawamorita Naoki、Mitsuzuka Koji、Arai Yoichi、Ito Akihiro
    • Journal Title

      International Journal of Urology

      Volume: 28 Issue: 1 Pages: 69-74

    • DOI

      10.1111/iju.14403

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Value of global metabolomics in association with diagnosis and clinicopathological factors of renal cell carcinoma2019

    • Author(s)
      Sato, T. (途中略),Koshiba, S., (途中略), Arai, Y.(合計15名、本研究者は13番目)
    • Journal Title

      Int. J. Cancer

      Volume: 145 Issue: 2 Pages: 484

    • DOI

      10.1002/ijc.32115

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improvement of Cardiac Function by Laparoscopic Adrenalectomy in a Patient with Severe Heart Failure Attributable to Primary Aldosteronism2019

    • Author(s)
      Sato Shin、Kawasaki Yoshihide、Ito Akihiro、Morimoto Ryo、Shimada Shuichi、Sato Takuma、Izumi Hideaki、Kawamorita Naoki、Yamashita Shinichi、Mitsuzuka Koji、Arai Yoichi
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 248 Issue: 1 Pages: 31-36

    • DOI

      10.1620/tjem.248.31

    • NAID

      130007650032

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2019 Research-status Report
  • [Presentation] グルタミノリシスの制御がチロンシンキナーゼ阻害剤抵抗性RCCに対する新規治療となり得る2021

    • Author(s)
      諸角 謙人
    • Organizer
      日本癌学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] メタボロミクス解析に基づく尿中代謝物測定による腎細胞癌術後の再発予測モデルの構築2021

    • Author(s)
      諸角 謙人
    • Organizer
      日本癌治療学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 癌代謝の観点からみた腎癌sunitinib耐性獲得機構の解明2020

    • Author(s)
      佐藤友紀, 川崎芳英, 前川正充, 高崎新也, 佐藤真彦, 嶋田修一, 伊藤明宏
    • Organizer
      日本癌学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 当科の転移性腎癌に対する免疫チェックポイント阻害薬の治療成績2020

    • Author(s)
      勝又有記, 川崎芳英, 諸角謙人, 方山博路, 佐竹洋平, 嶋田修一, 川守田直樹, 山下慎一, 三塚浩二, 伊藤明宏
    • Organizer
      日本癌治療学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 尿路上皮癌に対するペムブロリズマブの初期使用経験/効果を予測する臨床バイオマーカーの検討2019

    • Author(s)
      嶋田 修一
    • Organizer
      日本泌尿器科学会総会 107回
    • Related Report
      2019 Research-status Report
  • [Presentation] グローバルメタボロミクスを用いた腎癌の診断と臨床病理学的因子に関わる代謝化合物の評価2019

    • Author(s)
      佐藤 友紀
    • Organizer
      日本泌尿器科学会総会 107回
    • Related Report
      2019 Research-status Report
  • [Presentation] 多施設共同前向き研究からみた腎癌に対する腎摘除術後の腎機能に及ぼす因子の検討2019

    • Author(s)
      川崎 芳英
    • Organizer
      日本泌尿器科学会総会 107回
    • Related Report
      2019 Research-status Report
  • [Book] 泌尿器科当直医マニュアル】入院編 術後合併症 術後創部感染2021

    • Author(s)
      嶋田修一
    • Total Pages
      3
    • Publisher
      医学書院
    • Related Report
      2021 Annual Research Report
  • [Book] 泌尿器科の術式別術後管理Do&Do Not!観察ポイントがひとめでわかるチェックリストつき chapter 3 膀胱 11 新膀胱造設術の術後管理2020

    • Author(s)
      嶋田修一
    • Total Pages
      5
    • Publisher
      メディカ出版
    • Related Report
      2020 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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