| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Placental growth factor (PlGF) belongs to vascular endothelial growth factor (VEGF) family proteins which participate in angiogenesis and vasculogenesis. In late years, the cytoprotective role of VEGF family molecules is recognized but the physiological role of PlGF was still unknown. In this study, the physiological role of PlGF in the retinal pigment epithelium (RPE) which is important for the homeostasis of retinal tissue was investigated, and it was demonstrated that PlGF protects VEGFR2 protein from proteasomal degradation through GSK3 inactivation. The current data indicate that PlGF protects RPE cells via stabilization of VEGFA/VEGFR-2 signaling.
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