Molecular mechanism of skeletal muscle and brain atrophy with aging and preventive effect of exercise training
| Project/Area Number |
18K17811
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 59020:Sports sciences-related
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| Research Institution | Fukuoka University |
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Principal Investigator |
Ra Song-Gyu 福岡大学, スポーツ科学部, 助教 (60741999)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アポトーシス / 骨格筋 / チオレドキシン相互作用タンパク質 / 脳 / 老化 / チオレドキシン結合タンパク質 |
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| Outline of Final Research Achievements |
We examined the possibility that the increase in TXNIP protein expression with aging may cause skeletal muscle and brain atrophy.In the skeletal muscle, although TXNIP protein expression level increased with aging, exercise training did not decrease TXNIP protein expression. Similarly, in the brain, the expression level of TXNIP increased with aging. Exercise training at a young age reduced the TXNIP expression level in the brain, whereas exercise training at a old age did not reduce the TXNIP expression in the brain.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の結果から、老化にともなって骨格筋や脳が萎縮する時に、TXNIP発現量が増加する可能性が示された。老化にともなう骨格筋や脳の萎縮は、それぞれサルコペニアと認知症の発症につながるが、そのメカニズムは十分明らかにされていない。このメカニズムにTXNIPが関与している可能性が示されたことから、老化にともなうサルコペニアや認知症予防の研究の発展に寄与する研究成果であると考える。
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Report
(3 results)
Research Products
(9 results)
