A possible mechanism of Alzheimer's disease caused by lipid peroxidation

• Project/Area Number: 18K19673
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 58:Society medicine, nursing, and related fields
• Research Institution: Mie University
• Principal Investigator: OIKAWA Shinji 三重大学, 医学系研究科, 准教授 (10277006)
• Co-Investigator(Kenkyū-buntansha): 山嶋 哲盛 金沢大学, 医学系, 協力研究員 (60135077) ; 小林 果 三重大学, 医学系研究科, 講師 (70542091)
• Project Period (FY): 2018-06-29 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: アルツハイマー病 / プロテオミクス解析 / 過酸化脂質 / 酸化ストレス / バイオマーカー / 海馬 / 神経細胞死 / 4-ヒドロキシノネナール / 細胞死 / GPR40

Outline of Final Research Achievements

Alzheimer's disease is the most common type of dementia and progressive neurodegenerative disease. The recent findings suggest that lipid peroxidation plays an important role in the pathogenesis of Alzheimer's disease. It is well known that lipids are oxidized by heating to produce lipid peroxides, which further cause oxidative stress in the body. In the present study, we investigated the induction of cell death and changes in oxidative damage proteins in monkeys exposed to oxidative stress.

Academic Significance and Societal Importance of the Research Achievements

ω-6系の食用油が加熱されることにより生じる過酸化脂質が、アルツハイマー病や2型糖尿病、非アルコール性脂肪肝炎などの生活習慣病に関与することが最近明らかになりつつある。過酸化脂質は、生体内で酸化ストレスを引き起こし細胞死を誘導する。本研究により、過酸化脂質などにより誘導される酸化ストレスが細胞死を引き起こすメカニズムの一端が明らかになり、生活習慣病の予防法の開発にもつながることが期待される。

Research Products

• [Journal Article] Proteomic identification of the proteins related to cigarette smoke-induced cardiac hypertrophy in spontaneously hypertensive rats (2020)
  • Author(s): Kitamura Yuki、Mise Nathan、Mori Yurie、Suzuki Yuka、Ohashi Tomoki、Tada-Oikawa Saeko、Tokisu Masaki、Zong Cai、Oikawa Shinji、Ichihara Sahoko
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 1-12
  • DOI: 10.1038/s41598-020-75429-3
  • Peer Reviewed / Open Access
• [Journal Article] Proteomic analysis of the monkey hippocampus for elucidating ischemic resistance (2020)
  • Author(s): Mori Yurie、Oikawa Shinji、Kurimoto Shota、Kitamura Yuki、Tada-Oikawa Saeko、Kobayashi Hatasu、Yamashima Tetsumori、Murata Mariko
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 19-78 Issue: 2 Pages: 1-7
  • DOI: 10.3164/jcbn.19-78
  • NAID: 130007894919
  • Peer Reviewed / Open Access
• [Journal Article] Proteomic analysis of liver proteins of mice exposed to 1,2-dichloropropane. (2020)
  • Author(s): Zhang X, Morikawa K, Mori Y, Zong C, Zhang L, Garner E, Huang C, Wu W, Chang J, Nagashima D, Sakurai T, Ichihara S, Oikawa S, Ichihara G.
  • Journal Title: Arch Toxicol. Volume: 94 Issue: 8 Pages: 2691-2705
  • DOI: 10.1007/s00204-020-02785-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nitrative DNA damage in lung epithelial cells exposed to indium nanoparticles and indium ions (2020)
  • Author(s): Ahmed S, Kobayashi H, Afroz T, Ma N, Oikawa S, Kawanishi S, Murata M, Hiraku Y
  • Journal Title: Sci. Rep. Volume: 10 Issue: 1 Pages: 10741-10741
  • DOI: 10.1038/s41598-020-67488-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Combination of RERG and ZNF671 methylation rates in ccfDNA: a novel biomarker for screening of nasopharyngeal carcinoma (2020)
  • Author(s): Xu Y, Zhao W, Mo Y, Ma N, Midorikawa K, Kobayashi H, Hiraku Y, Oikawa S, Zhang Z, Huang G, Takeuchi K, Murata M.
  • Journal Title: Cancer Sci. Volume: Epub ahead of prin Issue: 7 Pages: 2536-2545
  • DOI: 10.1111/cas.14431
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CD44v9 Induces Stem Cell-Like Phenotypes in Human Cholangiocarcinoma (2020)
  • Author(s): Suwannakul Nattawan、Ma Ning、Midorikawa Kaoru、Oikawa Shinji、Kobayashi Hatasu、He Feng、Kawanishi Shosuke、Murata Mariko
  • Journal Title: Frontiers in Cell and Developmental Biology Volume: 8
  • DOI: 10.3389/fcell.2020.00417
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Polyphenols with Anti-Amyloid β Aggregation Show Potential Risk of Toxicity Via Pro-Oxidant Properties (2020)
  • Author(s): Kobayashi Hatasu、Murata Mariko、Kawanishi Shosuke、Oikawa Shinji
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 10 Pages: 3561-3561
  • DOI: 10.3390/ijms21103561
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Taurine Attenuates Carcinogenicity in Ulcerative Colitis-Colorectal Cancer Mouse Model (2020)
  • Author(s): Wang Guifeng、Ma Ning、He Feng、Kawanishi Shosuke、Kobayashi Hatasu、Oikawa Shinji、Murata Mariko
  • Journal Title: Oxidative Medicine and Cellular Longevity Volume: 2020 Pages: 1-7
  • DOI: 10.1155/2020/7935917
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mechanisms of DNA damage induced by morin, an inhibitor of amyloid β-peptide aggregation (2019)
  • Author(s): Mori Yurie、Kato Shinya、Fujisawa Yutaka、Ohnishi Shiho、Hiraku Yusuke、Kawanishi Shosuke、Murata Mariko、Oikawa Shinji
  • Journal Title: Free Radical Research Volume: 53 Issue: 1 Pages: 115-123
  • DOI: 10.1080/10715762.2018.1562179
  • Peer Reviewed
• [Journal Article] Anti-Cancer Mechanisms of Taurine in Human Nasopharyngeal Carcinoma Cells (2019)
  • Author(s): He Feng、Ma Ning、Midorikawa Kaoru、Hiraku Yusuke、Oikawa Shinji、Mo Yingxi、Zhang Zhe、Takeuchi Kazuhiko、Murata Mariko
  • Journal Title: Adv Exp Med Biol Volume: 2019;1155:533-541 Pages: 533-541
  • DOI: 10.1007/978-981-13-8023-5_49
  • ISBN: 9789811380228, 9789811380235
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Proteomic analysis of hippocampal proteins in acrylamide-exposed Wistar rats (2019)
  • Author(s): Nagashima D, Zhang L, Kitamura Y, Ichihara S, Watanabe E, Zong C, Yamano Y, Sakurai T, Oikawa S, Ichihara G
  • Journal Title: Archives of Toxicology Volume: 印刷中 Issue: 7 Pages: 1993-2006
  • DOI: 10.1007/s00204-019-02484-9
  • Peer Reviewed / Open Access
• [Journal Article] Overexpression of CD44 Variant 9: A Novel Cancer Stem Cell Marker in Human Cholangiocarcinoma in Relation to Inflammation (2018)
  • Author(s): Suwannakul Nattawan、Ma Ning、Thanan Raynoo、Pinlaor Somchai、Ungarreevittaya Piti、Midorikawa Kaoru、Hiraku Yusuke、Oikawa Shinji、Kawanishi Shosuke、Murata Mariko
  • Journal Title: Mediators of Inflammation Volume: 2018 Pages: 1-8
  • DOI: 10.1155/2018/4867234
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Proteomic profiling of exosomal proteins for blood-based biomarkers in Parkinson's Disease. (2018)
  • Author(s): Kitamura Y, Kojima M, Kurosawa T, Sasaki R, Ichihara S, Hiraku Y, Tomimoto H, Murata M, Oikawa S.
  • Journal Title: Neuroscience Volume: 392 Pages: 121-128
  • DOI: 10.1016/j.neuroscience.2018.09.017
  • Peer Reviewed / Open Access
• [Journal Article] Taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells through PTEN/Akt pathways in vitro (2018)
  • Author(s): He Feng、Ma Ning、Midorikawa Kaoru、Hiraku Yusuke、Oikawa Shinji、Zhang Zhe、Huang Guangwu、Takeuchi Kazuhiko、Murata Mariko
  • Journal Title: Amino Acids Volume: 50 Issue: 12 Pages: 1749-1758
  • DOI: 10.1007/s00726-018-2651-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] アミロイドβ凝集阻害剤MorinおよびDatiscetinのDNA損傷能を指標とした安全性評価 (2021)
  • Author(s): 八木 駿斗，小林 果，森 有利絵，加藤 信哉，川西 正祐, 村田 真理子, 及川 伸二
  • Organizer: 日本酸化ストレス学会東海支部第９回学術集会
• [Presentation] アクリルアミド代謝産物による塩基配列特異的DNA損傷機構 (2021)
  • Author(s): 森 有利絵，谷田川 みなみ，藤田 快男，加藤 信哉，小林 果，川西 正祐, 村田 真理子, 及川 伸二
  • Organizer: 第91回日本衛生学会学術総会
• [Presentation] Downregulation of GLUT5 suppresses cell proliferation and migration in cholangiocarcinoma cells (2021)
  • Author(s): Nattawan Suwannakul, Kaoru Midorikawa, Hatasu Kobayashi, Shinji Oikawa, Yasushi Arima, Shosuke Kawanishi, Mariko Murata
  • Organizer: 第91回日本衛生学会学術総会
• [Presentation] Knockdown of transferrin receptor 1 inhibits cell proliferation in nasopharyngeal carcinoma (2021)
  • Author(s): Guofei Feng, Yasushi Arima, Kaoru Midorikawa, Hatasu Kobayashi, Shinji Oikawa, Kazuhiko Takeuchi, Mariko Murata
  • Organizer: 第91回日本衛生学会学術総会
• [Presentation] Rnf213抑制はオスAkitaマウスと異なりメスAkitaマウスの糖尿病を改善しない (2021)
  • Author(s): Sharif Ahmed, Hatasu Kobayashi, Hiroko Okuda, Kouji H. Harada, Toshiyuki Habu, Shohab Youssefian, Shinji Oikawa, Mariko Murata, Akio Koizumi
  • Organizer: 第91回日本衛生学会学術総会
• [Presentation] アミロイドβ凝集阻害剤MorinおよびDatiscetinのDNA損傷能 (2020)
  • Author(s): 小林 果, 森 有利絵，加藤 信哉，八木 駿斗, 川西 正祐, 村田 真理子, 及川 伸二
  • Organizer: 日本環境変異原学会第49回大会
• [Presentation] MorinとDatiscetinによる酸化的DNA損傷 (2020)
  • Author(s): 小林 果, 森 有利絵，加藤 信哉，藤澤 豊, 大西 志保, 川西 正祐, 村田 真理子, 及川 伸二
  • Organizer: 第73回日本酸化ストレス学会学術集会
• [Presentation] A novel screening biomarker of nasopharyngeal carcinoma using plasma cell-free DNA. (2020)
  • Author(s): Yifei Xu, Weilin Zhao, Yingxi Mo, Ning Ma, Kaoru Midorikawa, Hatasu Kobayashi, Yuske Hiraku, Shinji Oikawa, Zhe Zhang, Guangwu Huang, Kazuhiko Takeuchi, Mariko Murata
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] Epstein-Barr Virus and Human Papillomavirus coinfection in nasopharyngeal carcinoma by in situ hybridization (2020)
  • Author(s): Guofei Feng, Yasushi Arima, Kaoru Midorikawa, Hatasu Kobayashi, Shinji Oikawa, Kazuhiko Takeuchi, Mariko Murata
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] Fructose promotes cholangiocarcinoma cell proliferation via GLUT5 overexpression (2020)
  • Author(s): Nattawan Suwannakul, Kaoru Midorikawa, Shinji Oikawa, Hatasu Kobayashi, Ning Ma, Shosuke Kawanishi, Mariko Murata
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] アルツハイマー型認知症への進展を予測する血漿バイオマーカーの探索 (2020)
  • Author(s): 山路隆斗、森有利絵、森咲子、徳井麻綸佳、谷田川みなみ、小林果、山嶋哲盛、村田真理子、及川伸二
  • Organizer: 日本酸化ストレス学会東海支部 第8回学術集会
• [Presentation] アクリルアミドの代謝産物による酸化的DNA損傷 (2020)
  • Author(s): 田中彩華、森有利絵、江藤瑞、藤田快男、加藤信哉、小林果、川西正祐、村田真理子、及川伸二
  • Organizer: 日本酸化ストレス学会東海支部 第8回学術集会
• [Presentation] アミロイドβ凝集阻害剤Morinにより誘導される酸化的DNA損傷機構 (2020)
  • Author(s): 森有利絵、加藤信哉、藤澤豊、大西志保、小林果、川西正祐、村田真理子、及川伸二
  • Organizer: 第19回分子予防環境医学研究会
• [Presentation] 発がん性アクリルアミド による酸化的DNA損傷機構 (2020)
  • Author(s): 森有利絵、田中彩華、江藤瑞、藤田快男、加藤信哉、小林果、川西正祐、村田真理子、及川伸二
  • Organizer: 第90回日本衛生学会学術総会
• [Presentation] RNF213調節不全は両側総頸動脈狭窄マウスモデルの脳低灌流を悪化させる (2020)
  • Author(s): 小林果、森本貴昭、原田浩二、奥田裕子、Shohab Youssefian、及川伸二、村田真理子、小泉昭夫
  • Organizer: 第90回日本衛生学会学術総会
• [Presentation] Roles of CD44 variant 9 in human cholangiocarcinoma cell progression. (2020)
  • Author(s): Nattawan Suwannakul, Kaoru Midorikawa, Shinji Oikawa, Hatasu Kobayashi, Ning Ma, Shosuke Kawanishi, Mariko Murata
  • Organizer: 第90回日本衛生学会総会
• [Presentation] 潰瘍性大腸炎-大腸がんモデルマウスに対するタウリンの抗がん作用 (2020)
  • Author(s): 王 桂鳳、有馬 寧、何 峰、川西 正祐、小林果、及川伸二、村田 真理子
  • Organizer: 第90回日本衛生学会総会
• [Presentation] DNA methylation biomarkers for nasopharyngeal carcinoma (2020)
  • Author(s): Yifei Xu, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Hatasu Kobayashi, Shinji Oikawa, Yingxi Mo, Zhe Zhang, Guangwu Huang, Kazuhiko Takeuchi, Mariko Murata
  • Organizer: 第90回日本衛生学会総会
• [Presentation] Relationship between stem cell marker CD44v9 and inflammation-related DNA damage in nasopharyngeal carcinoma (2020)
  • Author(s): Feng He, Ning Ma, Kaoru Midorikawa, Hatasu Kobayashi, Shinji Oikawa, Zhe Zhang, Guangwu Huang, Kazuhiko Takeuchi, Mariko Murata
  • Organizer: 第90回日本衛生学会総会
• [Presentation] インジウム化合物に曝露した肺上皮細胞における炎症反応を介したニトロ化DNA損傷 (2020)
  • Author(s): Sharif Ahmed、小林果、Tahmina Afroz、有馬寧、 及川伸二、川西正祐、村田真理子、平工雄介
  • Organizer: 第90回日本衛生学会総会
• [Presentation] Dysregulation and clinical significance of TFRC and SLC40A1 in head and neck squamous cell carcinoma (2020)
  • Author(s): Guofei Feng, Yasushi Arima, Kaoru Midorikawa, Hatasu Kobayashi1, Shinji Oikawa, Kazuhiko Takeuchi, Mariko Murata
  • Organizer: 第90回日本衛生学会総会
• [Presentation] 軽度認知障害段階におけるアルツハイマー型認知症の早期診断バイオマーカーの探索 (2019)
  • Author(s): 森有利絵、本城貴志、北村祐貴、山嶋哲盛、村田真理子、及川伸二
  • Organizer: 第42回日本基礎老化学会大会
• [Presentation] アミロイドβ凝集阻害剤Morinにより誘導されるDNA損傷機構の解明 (2019)
  • Author(s): 森有利絵、加藤信哉、藤澤豊、大西志保、小林果、川西正祐、村田真理子、 及川伸二
  • Organizer: 日本衛生学会
• [Presentation] Mechanisms of oxidative DNA damage induced by morin (2019)
  • Author(s): Yurie Mori, Shinya Kato, Yutaka Fujisawa, Kazuaki Kawai, Shiho Ohnishi, Hatasu Kobayashi, Shosuke Kawanishi, Mariko Murata, Shinji Oikawa
  • Organizer: 9th Meeting of SFRR (A+J)
  • Int'l Joint Research
• [Presentation] Potential role of CD44v9 on tumorigenic and redox responses in human cholangiocarcinoma (2019)
  • Author(s): Nattawan Suwannakul, Kaoru Midorikawa, Shinji Oikawa, Hatasu Kobayashi, Ning Ma, Shosuke Kawanishi, Mariko Murata
  • Organizer: 9th Meeting of SFRR (A+J)
  • Int'l Joint Research
• [Presentation] RNF213 dysregulation aggravate cerebral hypoperfusion in carotid artery stenosis mouse model (2019)
  • Author(s): Hatasu Kobayashi, Takaaki Morimoto, Kouji Harada, Hiroko Okuda, Shohab Youssefian, Shinji Oikawa, Mariko Murata, Akio Koizumi
  • Organizer: 9th Meeting of SFRR(A+J)
  • Int'l Joint Research
• [Presentation] Effects of CD44v9 knockdown on tumor progression of human cholangiocarcinoma cells (2019)
  • Author(s): Nattawan Suwannakul, Kaoru Midorikawa, Shinji Oikawa, Hatasu Kobayashi, Ning Ma, Shosuke Kawanishi, Mariko Murata
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Potential epigenetic biomarkers for nasopharyngeal carcinoma (2019)
  • Author(s): Yifei Xu, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Hatasu Kobayashi, Shinji Oikawa, Yingxi Mo, Zhe Zhang, Guangwu Huang, Kazuhiko Takeuchi, Mariko Murata
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] GDF10 inhibits the epithelial-mesenchymal transition in nasopharyngeal carcinoma (2019)
  • Author(s): Feng He, Ning Ma, Kaoru Midorikawa, Hatasu Kobayashi, Shinji Oikawa, Zhe Zhang, Guangwu Huang, Kazuhiko Takeuchi, Mariko Murata
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Elucidation of oxidative DNA damage mechanisms induced by morin (2019)
  • Author(s): Yurie Mori, Shinya Kato, Yutaka Fujisawa, Shiho Ohnishi, Hatasu Kobayashi, Shosuke Kawanishi, Mariko Murata, Shinji Oikawa
  • Organizer: ACEM/JEMS 2019
  • Int'l Joint Research
• [Presentation] 軽度認知障害とアルツハイマー型認知症の血漿プロテオミクス解析 (2019)
  • Author(s): 有利絵、本城貴志、山嶋哲盛、村田真理子、及川伸二.
  • Organizer: 第89回日本衛生学会学術総会
• [Presentation] RERG hypermethylation in circulating cell-free DNA of nasopharyngeal carcinoma: a potential hematological marker for screening. (2019)
  • Author(s): Yifei Xu, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Mariko Murata.
  • Organizer: 第89回日本衛生学会学術総会
• [Presentation] Predominant expression levels of CD44 variants in cholangiocarcinoma cell line. (2019)
  • Author(s): Nattawan Suwannakul, Ning Ma, Kaoru Midorikawa, Shinji Oikawa, Shosuke Kawanishi, Mariko Murata.
  • Organizer: 第89回日本衛生学会総会
• [Presentation] Taurine exhibits an anti-proliferation effect on human nasopharyngeal carcinoma cells in vivo. (2019)
  • Author(s): Feng He, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Kazuhiko Takeuchi, Mariko Murata.
  • Organizer: 第89回日本衛生学会学術総会
• [Presentation] アルツハイマー病患者血漿エクソソーム中のタンパク質解析 (2019)
  • Author(s): 森咲子、森有利絵、山路隆斗、舩山華奈子、小嶋みどり、佐藤正之、市原佐保子、埜村智之、石川雅一、村田真理子、冨本秀和、及川伸二
  • Organizer: 日本酸化ストレス学会東海支部第7回学術集会
• [Presentation] 軽度認知障害患者血漿における酸化損傷タンパク質の解析 (2019)
  • Author(s): 宇野菜摘、森有利絵、宇野優市、山嶋哲盛、村田真理子、及川伸二
  • Organizer: 日本酸化ストレス学会東海支部第7回学術集会
• [Presentation] 軽度認知障害患者を対象としたアルツハイマー病の早期診断に関する血漿プロテオミクス解析 (2018)
  • Author(s): 森有利絵、本城貴志、北村祐貴、山嶋哲盛、村田真理子、及川伸二.
  • Organizer: 第64回日本薬学会東海支部大会
• [Presentation] 虚血再灌流後のサル海馬CA1とDGにおけるプロテオミクス解析 (2018)
  • Author(s): 森有利絵、栗本将多、北村祐貴、及川(多田)佐枝子、村田真理子、山嶋哲盛、及川伸二.
  • Organizer: 第71回日本酸化ストレス学会学術集会
• [Presentation] Taurine induces Apoptosis in Human Nasopharyngeal Carcinoma Cells through PTEN-mediated inhibition of Akt pathway in Vitro. The 21st International Taurine MeetingTaurine induces Apoptosis in Human Nasopharyngeal Carcinoma Cells through PTEN-mediated inhibition of Akt pathway in Vitro. (2018)
  • Author(s): Feng He, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Kazuhiko Takeuchi, Mariko Murata
  • Organizer: The 21st International Taurine Meeting
  • Int'l Joint Research
• [Presentation] GDF10 is a candidate tumor suppressor gene inactivated by promoter hypermethylation in human nasopharyngeal carcinoma. (2018)
  • Author(s): Feng He, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Zhe Zhang, Guangwu Huang, Kazuhiko Takeuchi, Mariko Murata.
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] A novel cancer stem cell biomarker CD44v9 in liver fluke-related cholangiocarcinoma. (2018)
  • Author(s): Nattawan Suwannakul, Ning Ma, Raynoo Thanan, Somchai Pinlaor, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Shosuke Kawanishi, Mariko Murata.
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] DNA methylation in circulating cell-free DNA of nasopharyngeal carcinoma. (2018)
  • Author(s): Yifei Xu, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Zhe Zhang, Guangwu Huang, Kazuhiko Takeuchi, Mariko Murata.
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] 銅イオン及び鉄イオン存在下におけるフラボノイド類MorinによるDNA損傷機構 (2018)
  • Author(s): 有利絵、加藤信哉、川西正祐、村田真理子、及川伸二.
  • Organizer: 日本環境変異原学会第47回大会
• [Remarks]
  • URL: https://www.medic.mie-u.ac.jp/eiseigaku/
• [Remarks] 三重大学大学院医学系研究科 環境分子医学
  • URL: http://www.medic.mie-u.ac.jp/eiseigaku/
• [Remarks] 三重大学 大学院医学系研究科 環境分子医学
  • URL: http://www.medic.mie-u.ac.jp/organization/course/eiseigaku/