Mechano- and chem-gradient gel for novel scaffold using in tissue repair

Research Project

Project/Area Number	18K19907
Research Category	Grant-in-Aid for Challenging Research (Exploratory)
Allocation Type	Multi-year Fund
Review Section	Medium-sized Section 90:Biomedical engineering and related fields
Research Institution	University of Toyama
Principal Investigator	Nakaji-Hirabayashi Tadashi 富山大学, 学術研究部工学系, 准教授 (10543217)
Co-Investigator(Kenkyū-buntansha)	松村和明北陸先端科学技術大学院大学, 先端科学技術研究科, 教授 (00432328)
Project Period (FY)	2018-06-29 – 2021-03-31
Project Status	Completed (Fiscal Year 2020)
Budget Amount *help	¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000) Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords	メカノケミグラジエントゲル / 軟骨再生 / 傾斜階層構造 / 人工組織体 / 高分子ゲル / ハイドロゲル / メカノバイオロジー / 間葉系幹細胞 / キメラペプチド / メカノ・ケミグラジエントゲル / キメラタンパク質
Outline of Final Research Achievements	The key point on the research is the construction of gel material for chondrocytes tissue having the hierarchical structure. In the research, we could develop the mechano-gradient gel to work as trigger for constructing the chondrocytes tissue having the hierarchical structure. Although this gel material need the improvement and optimization for effective differentiation from hMSCs to chondrocytes, we got the important and great achievement for the in vitro construction of the artificial cartilage.
Academic Significance and Societal Importance of the Research Achievements	本研究課題は，変性軟骨疾患の再生医療の発展に貢献する可能性を秘めた萌芽的研究であり，社会的意義が非常に大きな研究であることはもちろんのこと，高分子ゲルと細胞を組み合わせて，生体組織にできる限り近づけた人工組織を，生体外で構築できる方法の提案につながる可能性を秘めており，再生医学・バイオマテリアル工学の発展にとっても非常に意義のある研究課題といえる。