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Mass drug administration of Artemisinin and Ivermectin toward malaria elimination in tropical Africa

Research Project

Project/Area Number 18KK0248
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Research InstitutionOsaka City University

Principal Investigator

KANEKO Akira  大阪市立大学, 大学院医学研究科, 教授 (60169563)

Co-Investigator(Kenkyū-buntansha) 皆川 昇  長崎大学, 熱帯医学研究所, 教授 (00363432)
城戸 康年  大阪市立大学, 大学院医学研究科, 准教授 (90511395)
加賀谷 渉  大阪市立大学, 大学院医学研究科, 病院講師 (20782577)
上坂 侑子 (坂本 侑子 / 坂本)  大阪市立大学, 大学院医学研究科, 前期臨床研究医 (50831525)
Project Period (FY) 2018-10-09 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2021: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2020: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsマラリア / 伝播 / 分子疫学 / ケニア / 媒介蚊対策 / 天井式蚊帳 / イベルメクチン / 媒介化対策 / 集団投薬 / アルテミシニン
Outline of Final Research Achievements

In this study, we examined the effectiveness of mass drug administration (MDA) with antimalarials in the Lake Victoria region of Kenya, and found that MDA is useful even in highly malaria-endemic areas such as the target site, but still there is the risk of resurgence of transmission. At the same time, the effectiveness of indoor residual spraying (IRS), one of the main methods of vector control, was also tested, with results suggesting that while it can suppress malaria prevalence significantly, it is not sustainable and has cost-effectiveness issues. These findings led to another research plan to construct and validate a novel vector control strategy, ceiling net.

Academic Significance and Societal Importance of the Research Achievements

マラリアは、現生人類の進化とともに共生してきた古い原虫感染症であるが、人類にとって常に最大の健康上の課題であり続けている。いかにして世界的なマラリア撲滅を達成するかは、ポストコロナの世界において今世紀に我々が直面するグローバルヘルスの最大の課題の一つである。本研究によって得られた、集団投薬あるいは室内残留型殺虫剤噴霧といった対策法の効果についての知見は、マラリア伝播と介入策の関係性を理解し、今後のマラリア対策戦略を構築するうえで有益な情報となる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (13 results)

All 2022 2021 2019 Other

All Int'l Joint Research (4 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results)

  • [Int'l Joint Research] マウントケニア大学/ホマベイ郡保健省(ケニア)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] マウントケニア大学/ホマベイ郡政府保健省(ケニア)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] マウントケニア大学/ケニア中央医学研究所(ケニア)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] マウントケニア大学/KEMRI/ホマベイ郡保健省(ケニア)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Malaria resurgence after significant reduction by mass drug administration on Ngodhe Island, Kenya2019

    • Author(s)
      Kagaya Wataru、Gitaka Jesse、Chan Chim W.、Kongere James、Md Idris Zulkarnain、Deng Changsheng、Kaneko Akira
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 19060-19060

    • DOI

      10.1038/s41598-019-55437-8

    • NAID

      120006988338

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Evaluation of OlysetPlus ceiling net in Lake Victoria basin, Kenya: a cluster-randomized trial2022

    • Author(s)
      Wataru Kagaya, James Kongere, Protus Omondi, Chim Chan, Gordon Okomo, Bernard Kanoi, Jesse Gitaka, Noboru Minakawa, Akira Kaneko
    • Organizer
      12th KEMRI Annual Scientific and Health Conference, Kenya
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mixed Plasmodium falciparum infections and disease outcomes in the Lake Victoria region, Western Kenya2022

    • Author(s)
      Protus Omondi, Brian Musyoka, Takatsugu Okai, James Kongere, Wataru Kagaya, Chim W. Chan, Jesse Gitaka, Akira Kaneko
    • Organizer
      12th KEMRI Annual Scientific and Health Conference, Kenya
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characterization of the genetic variation present in CYP3A4 in population living around the L. Victoria region, Western Kenya2022

    • Author(s)
      Brian Musyoka, Chim W. Chan, Protus Omondi, Takatsugu Okai, James Kongere, Caroline Kijogi, Mtakai Ngara, Wataru Kagaya, Jesse Gitaka, Akira Kaneko
    • Organizer
      12th KEMRI Annual Scientific and Health Conference, Kenya
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 室内残留型殺虫剤噴霧(IRS)によるマラリア伝播抑制とIRS中断後の伝播再興2021

    • Author(s)
      加賀谷渉、本多可愛、Chim Chan、James Kongere、Gordon Okomo、Jesse Gitaka、金子明
    • Organizer
      第76回日本寄生虫学会西日本支部大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Impact of indoor residual spray (IRS) on malaria prevalence in the Lake Victoria basin, Homa Bay, Kenya2021

    • Author(s)
      加賀谷渉、本多可愛、Chim Chan、James Kongere、Gordon Okomo、Jesse Gitaka、金子明
    • Organizer
      5th Africa International Biotechnology and Biomedical Conference
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The impact of indoor residual spraying for malaria prevalence in Homa Bay County, Kenya: an observational study2019

    • Author(s)
      Wataru Kagaya, Aya Konishi, Kyoko Kurihara, Chim Chan, Jesse Gitaka, James Kongere, Kinya Uchihashi, Gordon Okomo, Akira Kaneko
    • Organizer
      American Society of Tropical Medicine and Hygiene 68th annual meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] An interdisciplinary approach to combat residual malaria transmission in the Lake Victoria basin, Kenya.2019

    • Author(s)
      Akira Kaneko
    • Organizer
      The 9th KASH Conference
    • Related Report
      2018 Research-status Report
  • [Presentation] ケニア・ヴィクトリア湖周辺地域におけるマラリア感染率の低下2019

    • Author(s)
      中川達、仁田原彩、吉田真未、James Kongere、加賀谷渉、城戸康年、金子明
    • Organizer
      第88回日本寄生虫学会大会
    • Related Report
      2018 Research-status Report

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Published: 2018-10-12   Modified: 2023-01-30  

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