| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2021: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Outline of Final Research Achievements |
IgG4-related disease (IgG4-RD) is a disease characterized by systemic organ involvement, T- and B-cell infiltration of affected organs, and specific immunoglobulin class switching (mainly IgG4). In this study, we identified IL10+IL21+LAG3+Tfh cells involved in the specific class switching of IgG4-RD by single-cell gene expression analysis of T cells infiltrating affected organs with IgG4-RD. We also found that many of the class-switched B cells expressing AID also express high levels of IL10 and IL21 receptors.
|
