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Modelling of Antibiotics Behavior in the Water Environment of the Thees River, England

Research Project

Project/Area Number 18KK0290
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 63:Environmental analyses and evaluation and related fields
Research InstitutionKyoto University

Principal Investigator

Tanaka Hiroaki  京都大学, 工学研究科, 名誉教授 (70344017)

Co-Investigator(Kenkyū-buntansha) 花本 征也  金沢大学, 環境保全センター, 准教授 (10727580)
小川 文章  国立研究開発法人土木研究所, 土木研究所(つくば中央研究所), 上席研究員 (60589133)
山下 洋正  国立研究開発法人土木研究所, 土木研究所(つくば中央研究所), 上席研究員 (80355940)
Project Period (FY) 2018-10-09 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2020: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2019: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords抗生物質 / 河川流域 / 廃水処理施設 / 存在実態 / 流出モデル / 経験モデル / 日英内分泌かく乱物質共同研究 / 畜産排水 / 河川 / 流域 / 環境動態 / 生活排水 / 下水道 / 浄化槽 / 化学物質 / 畜産 / 河川水 / 底質 / 下水処理水 / 分配 / 吸着 / 分解 / 予測モデル / 桂川 / テムズ川 / 減衰速度 / 収着 / 環境予測モデル
Outline of Final Research Achievements

To understand the behavior of antibiotics in aquatic environments and construct a prediction model, we investigated the discharge status of antibiotics and other substances in eight rivers within Japan. We compared these findings with predictions from an emission source model. Additionally, we participated in a joint research workshop between Japan and the United Kingdom, where we presented our results and conducted on-site investigations in the Thames River. We revealed that animal antibiotics accounted for a significant proportion, particularly in the Kanzokugawa and Oyodogawa rivers. We compared the estimated discharge volumes based on theoretical and empirical models with actual measurements in the rivers. While human pharmaceuticals showed high predictive accuracy, there was variability in the prediction accuracy for animal pharmaceuticals. Factors such as the number of livestock farms and wastewater treatment processes appeared to influence the prediction accuracy.

Academic Significance and Societal Importance of the Research Achievements

人や家畜に投与された抗生物質が水環境中に排出され、生態影響や薬剤耐性菌の環境での水平伝搬が懸念されており、環境を含めた抗生物質の適性管理が必要である。環境分野では、抗生物質の水環境中濃度の実態把握が行われ始めたが、モニタリングには限界があり、水環境中濃度の予測システムとの連携が必要である。排出量の予測に必要な廃水処理での知見は徐々に明らかになってきたが、河川流下過程における抗生物質の水質変換の知見が不足している。本研究成果は、医薬品の排出源からの負荷量を推定する方法を提案し、日英内分泌化学物質共同研究での議論に利用される。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (27 results)

All 2023 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (4 results) Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 1 results) Presentation (14 results) (of which Int'l Joint Research: 8 results) Book (1 results)

  • [Int'l Joint Research] Centre for Ecology &Hydrology/Oxford University(英国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Centre for Ecology and Hydrology(英国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Center for Ecology and Hyrology(英国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Center for Ecology and Hydrology(英国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Spatiotemporal distribution of veterinary and human drugs and its predictability in Japanese catchments2023

    • Author(s)
      Seiya Hanamoto, Ryoko Yamamoto-Ikemoto, Hiroaki Tanaka
    • Journal Title

      Science of The Total Environment

      Volume: 867 Pages: 161514-161514

    • DOI

      10.1016/j.scitotenv.2023.161514

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Localized pollution of veterinary antibiotics in watersheds receiving treated effluents from swine farms2023

    • Author(s)
      Hanamoto Seiya、Minami Yuki、Hnin Su Su Thet、Yao Dingwen
    • Journal Title

      Science of The Total Environment

      Volume: 902 Pages: 166211-166211

    • DOI

      10.1016/j.scitotenv.2023.166211

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In-stream sorption of azithromycin and levofloxacin in a river receiving sewage treatment plant effluent2022

    • Author(s)
      Hanamoto Seiya、Yamamoto-Ikemoto Ryoko
    • Journal Title

      Environmental Pollution

      Volume: 307 Pages: 119568-119568

    • DOI

      10.1016/j.envpol.2022.119568

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biological Activity-Based Prioritization of Pharmaceuticals in Wastewater for Environmental Monitoring: G Protein-Coupled Receptor Inhibitors2020

    • Author(s)
      Zhang Han、Ihara Mariko O.、Nakada Norihide、Tanaka Hiroaki、Ihara Masaru
    • Journal Title

      Environmental Science & Technology

      Volume: 54 Issue: 3 Pages: 1720-1729

    • DOI

      10.1021/acs.est.9b05768

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Wastewater‐derived antagonistic activities of G protein‐coupled receptor‐acting pharmaceuticals in river water2020

    • Author(s)
      Ihara Masaru、Hanamoto Seiya、Ihara Mariko O.、Zhang Han、Tanaka Hiroaki
    • Journal Title

      Journal of Applied Toxicology

      Volume: 2020 Issue: 7 Pages: 32077112-32077112

    • DOI

      10.1002/jat.3952

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Predicting the sorption of azithromycin and levofloxacin to sediments from mineral and organic components2019

    • Author(s)
      Hanamoto Seiya、Ogawa Fumiaki
    • Journal Title

      Environmental Pollution

      Volume: 255 Pages: 113180-113180

    • DOI

      10.1016/j.envpol.2019.113180

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] The different fate of antibiotics in the Thames River, UK, and the Katsura River, Japan2018

    • Author(s)
      Hanamoto, S., Nakada, N., Johnson, AC., Jürgens, MD., Yamashita, N., Tanaka, H.
    • Journal Title

      Environmental Science and Pollution Research

      Volume: 25 Issue: 2 Pages: 1903-1913

    • DOI

      10.1007/s11356-017-0523-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Source estimation of pharmaceuticals based on catchment population and in-stream attenuation in Yodo River watershed, Japan2018

    • Author(s)
      Hanamoto, S., Nakada, N., Yamashita, N., Tanaka, H.
    • Journal Title

      Science of the Total Environment

      Volume: 615 Pages: 964-971

    • DOI

      10.1016/j.scitotenv.2017.10.013

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Prediction and management of emerging chemicals in the water environment2023

    • Author(s)
      Hiroaki TANAKA, Masaru IHARA, Norihide NAKADA, Han ZHANG, Hiromasa YAMASHITA, Seiya HANAMOTO, Andrew JOHNSON, Monika JORGENS
    • Organizer
      The 23rd UK-Japan Annual Scientific Workshop Research into Environmental Endocrine Disrupting Chemicals & Chemicals of Emerging Concern
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prediction and management of emerging chemicals in the water environment2022

    • Author(s)
      Hiroaki TANAKA, Masaru IHARA, Norihide NAKADA, Han ZHANG,Hiromasa YAMASHITA, Seiya HANAMOTO
    • Organizer
      The 24rd UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals, On-line, 31st, October, 2022.
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 都市河川における陽イオン界面活性剤の存在実態と動態2022

    • Author(s)
      花本征也、南雄己
    • Organizer
      第57回日本水環境学会年会、2023年3月15日
    • Related Report
      2022 Research-status Report
  • [Presentation] 浅野川における塩基性医薬品の懸濁物質への吸着2022

    • Author(s)
      花本征也、池本良子
    • Organizer
      第 5 6 回日本水環 境学会年会
    • Related Report
      2021 Research-status Report
  • [Presentation] Prediction and management of emerging chemicals in the water environment2021

    • Author(s)
      Hiroaki TANAKA, Masaru IHARA, Norihide NAKADA, Han ZHANG Hiromasa YAMASHITA, Seiya HANAMOTO
    • Organizer
      The 2 3 rd UK Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals, O n line , 29 th , November, 20 21
    • Related Report
      2021 Research-status Report
  • [Presentation] 大淀川における動物用医薬品の通年調査と排出量予測2021

    • Author(s)
      花本征也、池本良子
    • Organizer
      第 55 回日本水 環境学会年会、
    • Related Report
      2020 Research-status Report
  • [Presentation] Prediction and management of emerging chemicals in the water environment2020

    • Author(s)
      Hiroaki Tanaka, Masaru Ihara , Hiromasa Yamashita, Seiya Hanamoto
    • Organizer
      The 22nd UK-Japan Annual Scientific Workshop Research into Environmental Endocrine Disrupting Chemicals & Chemicals of Emerging Concern
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prediction and management of emerging chemicals in the water environment2019

    • Author(s)
      Hiroaki TANAKA, Masaru IHARA, Norihide NAKADA, Han ZHANG,Hiromasa YAMASHITA, Seiya HANAMOTO
    • Organizer
      The 21th UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals, Otsu, Japan, 12th, November, 2019.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Modelling the Sorption of Quinolone Antibiotic Levofloxacin on Sediments2019

    • Author(s)
      Hanamoto Seiya, Ogawa Fumiaki
    • Organizer
      Water and Environmental Technology Conference 2019, Osaka, Japan, 2019 年7 月13 日
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Modelling the sorption of macrolide antibiotic azithromycin on sediments2019

    • Author(s)
      Hanamoto Seiya, Ogawa Fumiaki.
    • Organizer
      11th Micropol & Ecohazard Conference 2019, Seoul, Korea, 2019 年10 月21 日
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Detection of biological 20 activity of antidepressants in wastewater treatment plant effluents in Japan and UK using in vitro assay2019

    • Author(s)
      Daisuke Kato, Mariko Ihara, Han Zhang, Hiroaki Tanaka, Masaru Ihara
    • Organizer
      The 21th UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals, Otsu, Japan, 12th, November, 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] In vitro アッセイによる日本およびイギ リスの下水放流水中の抗うつ薬様活性の検出2019

    • Author(s)
      加藤大典、Zhang Han、井原満理子、田中宏明、井原賢
    • Organizer
      第22 回環境ホルモン学会研究発表会、 2019 年12 月12 日、要旨集p55.
    • Related Report
      2019 Research-status Report
  • [Presentation] Biological-activity-based prioritization of pharmaceuticals in wastewater in Japan and England2019

    • Author(s)
      Han Zhang, Masaru Ihara, Hiroaki Tanaka
    • Organizer
      第22 回環境ホルモン学会研究発表 会、2019 年12 月12 日、要旨集p64.
    • Related Report
      2019 Research-status Report
  • [Presentation] Prediction and management of emerging chemicals in the water environment2018

    • Author(s)
      Hiroaki TANAKA, Masaru IHARA, Norihide NAKADA, Han ZHANG, Fumiaki OGAWA, Seiya HANAMOTO, Andrew JOHNSON, Monika JURGENS
    • Organizer
      The 20th UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Book] ,Attenuation and fate of pharmaceuticals in river environments. in: Manish KumarFrancisco Munoz-ArriolaHiroaki FurumaiTushara Chaminda:resilience, response, and risk in water systems.2020

    • Author(s)
      Hanamoto, S.
    • Publisher
      Springer-Link
    • ISBN
      9789811546686
    • Related Report
      2020 Research-status Report

URL: 

Published: 2018-10-12   Modified: 2025-01-30  

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