Development of next generation multi-dimensional endoscope system

• Project/Area Number: 18KK0457
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55040:Respiratory surgery-related
• Research Institution: Hokkaido University
• Principal Investigator: Aragaki Masato 北海道大学, 医学研究院, 客員研究員 (30788245)
• Project Period (FY): 2018 – 2021
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
• Keywords: 肺癌 / 内視鏡 / 超音波内視鏡 / 光線力学的治療 / 胸腔鏡 / 細径内視鏡 / Photosesityzer / PDT / レーザー / 5-ALA / マウスxenograftモデル / photosensityzer / rabbit orthotopic model / endoscope / 蛍光マーキング / 光線力学的診断薬 / 蛍光

Outline of Final Research Achievements

We were involved in research and development on ultra thin endoscope, fluorescence, and ultrasound function required for next-generation endoscopes. First of all, we used ultra thin fiber scope made by OK fiber technology and the scanning fiber endoscope, and preliminary experiments on intra-airway observation and photodynamic therapy in mice were performed, and the results were presented. In terms of fluorescence, multiple photosensitizers called ALA, OTL38, Porphysome, and PLP are used to verify whether tumor site identification, photodynamic therapy, and regional lymph node identification are possible with an endoscope, and the results were reported. Regarding ultrasound endoscopy, we have developed and presented a new treatment procedure for pulmonary embolism by
Endobronchial Ultrasound Bronchoscopy.

Academic Significance and Societal Importance of the Research Achievements

内視鏡は現在医療においてすべての臓器・専門分野で重要な役割をしており、診断や治療に欠かせないツールである。内視鏡は患者の負担が少なく病変に到達し、病変や術野の拡大視により診断・治療を行う以外にも超音波や蛍光を利用することによりより多くの情報や治療デバイスとしての可能性を拡大している。この分野の進歩は診断効率の向上と医療の低侵襲化に大きな影響をあたえ、患者への貢献度は大きい。具体的には肺癌領域において、内視鏡の細径化はより抹消の病変へのアプローチを可能にし、さらにはそこに対する低侵襲な光線力学的治療の遂行を可能にするかもしれない。その理想的な低侵襲肺癌治療の基礎的研究を行えたこと意義は大きい。

Research Products

• [Int'l Joint Research] University of Toronto, University Health Network(カナダ) (2019)
  • Year and Date: 2019-04-03
• [Journal Article] Repeated porphyrin lipoprotein-based photodynamic therapy controls distant disease in mouse mesothelioma via the abscopal effect (2021)
  • Author(s): Lou Jenny、Aragaki Masato、Bernards Nicholas、Kinoshita Tomonari、Mo Jessica、Motooka Yamoto、Ishiwata Tsukasa、Gregor Alexander、Chee Tess、Chen Zhenchian、Chen Juan、Kaga Kichizo、Wakasa Satoru、Zheng Gang、Yasufuku Kazuhiro
  • Journal Title: Nanophotonics Volume: 10 Issue: 12 Pages: 3279-3294
  • DOI: 10.1515/nanoph-2021-0241
  • NAID: 120007126834
  • Peer Reviewed
• [Journal Article] Pilot study using virtual 4-D tracking electromagnetic navigation bronchoscopy in the diagnosis of pulmonary nodules: a single center prospective study (2021)
  • Author(s): Ishiwata Tsukasa、Ujiie Hideki、Gregor Alexander、Inage Terunaga、Motooka Yamato、Kinoshita Tomonari、Aragaki Masato、Chen Zhenchian、Effat Andrew、Bernards Nicholas、Yasufuku Kazuhiro
  • Journal Title: Journal of Thoracic Disease Volume: 13 Issue: 5 Pages: 2885-2895
  • DOI: 10.21037/jtd-21-141
  • NAID: 120007173235
• [Journal Article] A preclinical research platform to evaluate photosensitizers for transbronchial localization and phototherapy of lung cancer using an orthotopic mouse model (2021)
  • Author(s): Ishiwata Tsukasa、Seki Takeshi、Gregor Alexander、Aragaki Masato、Motooka Yamato、Kinoshita Tomonari、Inage Terunaga、Bernards Nicholas、Ujiie Hideki、Chen Zhenchian、Effat Andrew、Chen Juan、Zheng Gang、Tatsumi Koichiro、Yasufuku Kazuhiro
  • Journal Title: Translational Lung Cancer Research Volume: 10 Issue: 1 Pages: 243-251
  • DOI: 10.21037/tlcr-20-813
  • NAID: 120007169388
• [Journal Article] Thrombolysis of Pulmonary Emboli via Endobronchial Ultrasound-Guided Transbronchial Needle Injection (2020)
  • Author(s): Terunaga Inage, Kosuke Fujino, Yamato Motooka, Tsukasa Ishiwata, Hideki Ujiie, Nicholas Bernards, Alexander Grego, Zhenchian Chen, Masato Aragaki, Tomonari Kinoshita, Ichiro Yoshino, Kazuhiro Yasufuku
  • Journal Title: The Annals of Thoracic Surgery Volume: 20 Issue: 2 Pages: 395-404
  • DOI: 10.1016/j.athoracsur.2020.08.043
  • Peer Reviewed / Open Access / Int'l Joint Research