| Budget Amount *help |
¥561,470,000 (Direct Cost: ¥431,900,000、Indirect Cost: ¥129,570,000)
Fiscal Year 2011: ¥97,630,000 (Direct Cost: ¥75,100,000、Indirect Cost: ¥22,530,000)
Fiscal Year 2010: ¥107,380,000 (Direct Cost: ¥82,600,000、Indirect Cost: ¥24,780,000)
Fiscal Year 2009: ¥112,320,000 (Direct Cost: ¥86,400,000、Indirect Cost: ¥25,920,000)
Fiscal Year 2008: ¥117,130,000 (Direct Cost: ¥90,100,000、Indirect Cost: ¥27,030,000)
Fiscal Year 2007: ¥127,010,000 (Direct Cost: ¥97,700,000、Indirect Cost: ¥29,310,000)
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| Research Abstract |
Atg17, Atg29 and Atg31 form a stable ternary complex. Upon starvation Atg1-Atg13 joins to the complex and acts as a scaffold complex for the PAS. Other Atg proteins sequentially join to the PAS in a hierarchical manner. Using in vitro systems, we elucidated functions of the products of ubiquitin-like conjugation reactions, Atg8-PE and Atg12-Atg5. We studied selective degradation of mitochondria and identified an essential receptor, Atg32, which localizes on the mitochondrial outer membrane. Crystal structures of the most Atg proteins involved in the conjugation systems were determined.
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