Molecular mechanisms for a suppressive effect of calorie restriction on cancer induction by radiation
| Project/Area Number |
19201011
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tohoku University |
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Principal Investigator |
ONO Tetsuya Tohoku University, 大学院・医学系研究科, 教授 (00107509)
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| Co-Investigator(Kenkyū-buntansha) |
NORIMURA Toshiyuki 産業医科大学, 医学部, 教授 (20039530)
SHIMADA Yoshiya 放射線医学総合研究所, 発達期被ばく影響研究グループ, グループリーダー (10201550)
上原 芳彦 東北大学, 大学院・医学系研究科, 助教 (30223499)
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| Co-Investigator(Renkei-kenkyūsha) |
UEHARA Yoshihiko 東北大学, 大学院・医学系研究科, 助教 (30223499)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥46,540,000 (Direct Cost: ¥35,800,000、Indirect Cost: ¥10,740,000)
Fiscal Year 2009: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2008: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2007: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
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| Keywords | カロリー制限 / 突然変異 / 染色体異常 / 発現制御 / 放射線 / マイクロアレイ / ゲノム / 癌 |
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| Research Abstract |
Although calorie restriction is known to reduce radiation-induced cancer, little is understood for its mechanism. We have challenged this problem by studying mutation, chromosome abnormality, genome-wide gene expression, etc. The results showed no effect on mutation and chromosome abnormality. mRNA levels, on the other hand, revealed some alterations. These would provide important clues for further analyses of the problem.
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Report
(4 results)
Research Products
(19 results)
