Identification of a transcription factor complex which promotes nerve regeneration
| Project/Area Number |
19209005
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Osaka City University |
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Principal Investigator |
KIYAMA Hiroshi Osaka City University, 大学院・医学研究科, 教授 (00192021)
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| Co-Investigator(Kenkyū-buntansha) |
KONISHI Hiroyuki 大阪市立大学, 大学院・医学研究科, 助教 (90448746)
NAKAGOMI Saya 大阪市立大学, 大学院・医学研究科, 助教 (60423894)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2009: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2008: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2007: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
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| Keywords | 解剖学 / 脳神経 / 再生医学 / 転写因子 / 神経再生 / DINE / ATF3 / STAT3 / 組織再生 |
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| Research Abstract |
Nerve injury requires the expression of large ensembles of genes. The key molecular mechanism for this gene transcription regulation in injured neurons was poorly understood. We hypothesized an existence of transcription factor complex, which promoted expressions of multiple nerve injury associated molecules. In this study we have identified a promoter complex consisting of 4 transcription factors, ATF3, c-Jun, STAT3 and Sp1. This complex substantially promoted expression of nerve injury associated proteins such as DINE and SOD. This could be one of potent transcription factor complexes especially for nerve regeneration.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Molecular characterization and expression of the low-density lipoprotein receptor-related protein-10, a new member of the LDLR gene family.2010
Author(s)
Jeong YH, Ishikawa K, Someya Y, Hosoda A, Yoshimi T, Yokoyama C, Kiryu-Seo S, Kang MJ, Tachibana T, Kiyama H, Fukumura T, Kim DH, Saeki S
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Journal Title
Biochem Biophys Res Commun 391(1)
Pages: 1110-1115
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