| Budget Amount *help |
¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2009: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2008: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2007: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
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| Research Abstract |
Nerve injury requires the expression of large ensembles of genes. The key molecular mechanism for this gene transcription regulation in injured neurons was poorly understood. We hypothesized an existence of transcription factor complex, which promoted expressions of multiple nerve injury associated molecules. In this study we have identified a promoter complex consisting of 4 transcription factors, ATF3, c-Jun, STAT3 and Sp1. This complex substantially promoted expression of nerve injury associated proteins such as DINE and SOD. This could be one of potent transcription factor complexes especially for nerve regeneration.
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