| Project/Area Number |
19209057
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YAMAGUCHI Akira Tokyo Medical and Dental University, 医歯学総合研究科, 教授 (00142430)
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| Co-Investigator(Kenkyū-buntansha) |
勝部 憲一 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (20233760)
坂本 啓 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (00302886)
玉村 禎宏 東京医科歯科大学, 大学院・医歯学総合研究科, 特任助教 (70431963)
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| Co-Investigator(Renkei-kenkyūsha) |
KATSUBE Ken-Ichi 東京医科歯科大学, 医歯学総合研究科, 講師 (20233760)
KSAKAMOTO Kei 東京医科歯科大学, 医歯学総合研究科, 助教 (00302886)
TAMAMURA Yoshihiro 東京医科歯科大学, 医歯学総合研究科, 特任助教 (70431963)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2009: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2008: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2007: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
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| Keywords | 骨芽細胞 / 破骨細胞 / BMP / Notch / CCN3 / 口腔癌 / 骨再生 / 骨形成 / 骨リモデリング / 骨吸収 / 全身性因子 / Wnt |
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| Research Abstract |
We conducted experiments to elucidate cellular and molecular crosstalk during bone regeneration, and the following results were demonstrated. 1) Notch signal regulates osteoblast differentiation and bone formation, 2) CCN3 expression was greatly increased during bone regeneration, and CCN3 regulated osteoblast differentiation by crosstalk with BMP and Notch signals, 3) Crosstalk among oral cancer cells, fibroblastic cells interfacing bone surface and osteoclasts plays important roles in bone destruction by oral cancer. 4) Latexin is involved in chondrocyte differentiation during bone development and regeneration through BMP-Sox9 cascade, 5) BMP signaling is involved in pathobiology of sunovialchondromatosis.
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