| Project/Area Number |
19256003
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Endocrinology
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| Research Institution | Nagasaki University |
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Principal Investigator |
YAMASHITA Shunichi Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (30200679)
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| Co-Investigator(Kenkyū-buntansha) |
OHTSURU Akira 長崎大学, 大学病院, 准教授 (00233198)
TAKAMURA Noboru 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30295068)
NAKASHIMA Masahiro 長崎大学, 大学院・医歯薬学総合研究科, 教授 (50284683)
MITSUTAKE Norisato 長崎大学, 大学院・医歯薬学総合研究科, 助教 (50404215)
難波 裕幸 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (80237635)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥42,250,000 (Direct Cost: ¥32,500,000、Indirect Cost: ¥9,750,000)
Fiscal Year 2009: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2008: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2007: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
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| Keywords | チェルノブイリ / 小児甲状腺がん / 分子疫学調査 / がん組織バンク / 癌基礎研究 / がん基礎研究 / 放射線誘発がん / 甲状腺がん / 遺伝子多型 / 国際共同研究 |
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| Research Abstract |
In order to clarify the direct cause of childhood thyroid cancers rapidly increased after the Chernobyl accident and its health consequences, we have successfully performed the joint research projects on molecular epidemiology on a basis of overseas' counterparts. Especially we could deeply commit to the international radiation safety programs with WHO, NCRP and EU and further deepened our understanding of radiation risk analysis and management with them. We have continued the collection of data on radiation-exposed victims and their biomaterials from the former USSR (Belarus, Ukraine and Russia), and extracted the DNAs which were subjected to further analysis of SNPs including the major target genes such as DNA damage repairing enzymes. Our results indicated the positive association of some SNPs pattern with radiation-associated thyroid cancers including DNA damage repairing enzymes and anti-oncogenes. Simultaneously we have worked at the Chernobyl Tissue Bank under the international
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consortium program. Using the samples collected from Chernobyl, we have analyzed the pathological changes of radiation-associated thyroid cancers and found the clinico-pathological characteristics such as genotype-phenotype difference by its different aged group, latency difference and histological difference. Fortunately there are no clinical prognostic difference between non-radiation and radiation-induced thyroid cancers at the standpoint of recurrence rate and mortality, suggesting a fairly good prognosis of childhood thyroid cancers after appropriate therapy. Now the genome wide association study is under investigation using the samples collected from Chernobyl.
In conclusion, we have contributed to the revision of radiation safety guidelines on a basis of active participation on WHO and other international meetings using our own achievement. Besides the risk of external radiation exposure, internal exposure by radioactive iodines to neonate and children selectively and specifically increased the risk of radiation-induced thyroid cancers. Therefore our research progress can be expected to contribute to fundamental data on preventive measures of nuclear disaster and radiation safety standard guidelines that are also socially of a great significance. Less
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