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Non-verbal executive function in the left frontal lobe in patients with brain tumor resection

Research Project

Project/Area Number 19300093
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cognitive science
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

KUMADA Takatsune  National Institute of Advanced Industrial Science and Technology, 人間福祉医工学研究部門, 研究グループ長 (70221942)

Co-Investigator(Kenkyū-buntansha) MYRAGAKI Yoshihiro  東京女子医科大学, 脳神経外科, 准教授 (70210028)
MARUYAMA Takashi  東京女子医科大学, 脳神経外科, 講師 (40301543)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Keywords前頭葉 / 注意 / 遂行機能 / 脳波 / 脳機能イメージング
Research Abstract

We examined task-switching functions of frontal regions in patients with brain tumor using intracranial electrodes and voxel-based lesion symptom mapping (VLSM) techniques. In Study 1, EEG was recorded via electrodes planted in the left frontal lobe of a patient. An electrode in the left inferior frontal sulcus recorded negative potentials to the onset of a cue.In Study 2, 29 patients performed a cued visual search task. Their performance and resected brain areas were subjected to a VLSM procedure, showed that the left middle frontal region involved in configuration of task-set, whereas the left inferior frontal regions involved in maintenance of it. These results revealed that left frontal regions have different functions related to task-switching.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (10 results)

All 2009 2008 2007 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Disinhibition of sequential actions following right frontal lobe damage2009

    • Author(s)
      Niki, C., Maruyama, T., Muragaki, Y., Kumada, T
    • Journal Title

      Congnitive Neuropsychology 26

      Pages: 266-285

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Feature-based control of attention in normal and damaged brain.2008

    • Author(s)
      熊田孝恒
    • Organizer
      International Congress of Psychology
    • Place of Presentation
      ベルリン(ドイツ)
    • Year and Date
      2008-08-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Feature-based control of attention in normal and damaged brain2008

    • Author(s)
      熊田孝恒
    • Organizer
      International Congress of Psychology
    • Place of Presentation
      ドイツ、ベルリン
    • Year and Date
      2008-08-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 浩課題に対する構えの切り替えにおける島回前部の活動:深部電極からの脳波による検討ヒト脳機能マッピング学会2008

    • Author(s)
      熊田孝恒・仁木千晴.丸山隆志・村垣善
    • Place of Presentation
      山形市
    • Year and Date
      2008-06-06
    • Related Report
      2009 Final Research Report
  • [Presentation] 課題に対する構えの切り替えにおける島回前部の活動:深部電極からの脳波による検討2008

    • Author(s)
      熊田孝恒, 仁木千晴, 丸山隆志, 村垣善浩
    • Organizer
      ひと脳機能マッピング学会
    • Place of Presentation
      山形
    • Year and Date
      2008-06-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] Abnormal spatiotemporal dynamics of visual attention in patients without unilateral spatial neglect. "International Neuropsychological Society2008

    • Author(s)
      熊田孝恒、仁木千晴、丸山隆志、村垣善浩
    • Organizer
      36th Annual meeting
    • Place of Presentation
      ハワイ(アメリカ)
    • Year and Date
      2008-02-09
    • Related Report
      2009 Final Research Report
  • [Presentation] Abnormal spatiotemporal dynamics of visual attention in patientswithout unilateral spatial neglect2008

    • Author(s)
      熊田 孝恒
    • Organizer
      Intern ational Neuropsychological Society, 36th Annual meeting
    • Place of Presentation
      Hilton waikoloa Village, Hawaii, USA
    • Year and Date
      2008-02-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] 注意のトップダウン制御原理-次元加重、課題構え2007

    • Author(s)
      熊田孝恒
    • Organizer
      探索モード生理研研究会:認知神経科学の先端注意と意志決定の脳内メカニズム
    • Place of Presentation
      岡崎市
    • Year and Date
      2007-10-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 注意のトップダウン制御原理-次元加重、課題構え、探索モード2007

    • Author(s)
      熊田 孝恒
    • Organizer
      生理研研究会「認知神経科学の先端注意と意志決定の脳内メカニズム」
    • Place of Presentation
      生理学研究所(岡崎)
    • Year and Date
      2007-10-11
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.aist.go.jp/staff/t.kumada/index.html

    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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