| Project/Area Number |
19300123
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Gunma University |
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Principal Investigator |
NAKAZATO Yoichi Gunma University, 大学院・医学系研究科, 教授 (10106908)
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| Co-Investigator(Kenkyū-buntansha) |
HIRATO Junko 群馬大学, 医学部, 准教授 (60208832)
SASAKI Atsushi 埼玉医科大学, 医学部, 教授 (80225862)
YOKOO Hideaki 群馬大学, 大学院・医学系研究科, 准教授 (40282389)
ISHIUCHI Syogo 琉球大学, 医学部, 教授 (10312878)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2007: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 脳腫瘍 / 画像解析 / 遺伝子異常 / 病理診断 / 生物活性 / 脳腫病 |
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| Research Abstract |
We analyzed the features of brain tumors from the view point of tissue and cellular morphology, phenotypic expression, and genetic alterations. We found that small round cells expressing nuclear transcription factor Olig2 are commonly exist in diffuse astrocytoma, oligoastrocytoma, oligodendroglioma, pilocytic astrocytoma, and glioneuronal tumors. These cells are presumed to be the progenitor cells of brain tumors. As molecular biologic markers, our analysis has shown that GFAP, Olig2, nestin, and NFP are important at protein level, and IDH1, p53, EGFR, 1p/19q, and INI-1 are crucial in genetic alterations. We have established the basis of morphologic molecular classification of brain tumors by fusion of the molecular events and histopathological diagnosis.
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