Designing tissue engineering scaffolds for neural stem cell transplantation through protein engineering
Project/Area Number |
19300171
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biomedical engineering/Biological material science
|
Research Institution | Kyoto University |
Principal Investigator |
KATO Koichi Kyoto University, 再生医科学研究所, 准教授 (50283875)
|
Co-Investigator(Kenkyū-buntansha) |
IWATA Hiroo 京都大学, 再生医科学研究所, 教授 (30160120)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2007: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
|
Keywords | キメラタンパク質 / 再生医療 / 中枢神経 / 細胞増殖因子 / 幹細胞移植 / バイオマテリアル / ハイドロゲル / 自己組織化 / コイルドコイル / 神経幹細胞 / 細胞接着 / 組織工学 / 細胞移植 |
Research Abstract |
This project was aimed at developing protein-based biomaterials that serve to improve the survival and engraftment of neural stem/progenitor cells transplanted into central nervous tissues for therapeutic purposes. It was shown that hydrogels made of naturally-occurring polymers such as collagen and hyaluronic acid could be suitably used as base materials. In addition, protein engineering strategies were employed to incorporate growth factors, neurotrophic factors, and/or integrin binding polypeptide domains into the base materials. We demonstrated that such approaches were quite effective for improving survival of cells embedded in the hydrogels.
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Report
(4 results)
Research Products
(38 results)