Effect of physical exercise on obesity-induced adipose chronic inflammation : its molecular mechanism and the participation of macrophagesq

• Project/Area Number: 19300223
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Kyorin University
• Principal Investigator: OHNO Hideki Kyorin University, 医学部, 教授 (00133819)
• Co-Investigator(Kenkyū-buntansha): 木崎 節子 杏林大学, 医学部, 准教授 (00322446) ; 櫻井 拓也 杏林大学, 医学部, 助教 (20353477)
• Co-Investigator(Renkei-kenkyūsha): KIZAKI Takako 杏林大学, 医学部, 准教授 (00322446) ; SAKURAI Takuya 杏林大学, 医学部, 助教 (20353477) ; OGASAWARA Junnetsu 杏林大学, 医学部, 助教 (20415110)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000); Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2007: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
• Keywords: 運動 / 肥満 / 脂肪組織 / マクロファージ / 慢性炎症 / アディポカイン / 一酸化窒素 / 活性酸素 / TNF-α / ポリフェノール / PPARγ

Research Abstract

運動トレーニングは、内臓脂肪の酸化ストレスと、マクロファージ関連の炎症性アディポカインの発現を減少させた。酸化ストレスの低下は、抗酸化酵素の上昇によっていた。さらに、運動トレーニングはマクロファージによる細胞性免疫反応を増強し、一酸化窒素産生能を亢進して、感染防御能を高めることが示唆された。脂肪組織に対する効果は、皮下脂肪よりも内臓脂肪に強く現れる事実は、運動トレーニングが生活習慣病の予防・治療に有用であることを示唆する。

Research Products

• [Journal Article] Swimming training prevents induction of suppressor macrophages in mice during acute exposure to cold (2009)
  • Author(s): Ohno, H., Haga, S., Takemasa, T., Sakurai, T., Ogasawara, J., Shirato, K., Ishibashi Y., Imaizumi, K. and Kizaki T.
  • Journal Title: Adv. Exerc. Sports Physiol (in press)
  • NAID: 110007330710
  • Peer Reviewed
• [Journal Article] β-Adrenergic receptor regulates Toll-like receptor 4-induced TRIF-dependent late-phase NF-κB activation (2009)
  • Author(s): Kizaki, T., Shirato, K., Sakurai, T., Ogasawara, J., Oh-Ishi, S., Matsuoka, T., Izawa, T., Imaizumi, K., Haga, S. and Ohno, H.
  • Journal Title: Mol. Immunol 46 Pages: 1195-1203
  • Peer Reviewed
• [Journal Article] Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue (2009)
  • Author(s): Sakurai,T., Izawa, T., Kizaki, T., Ogasawara, J., Shirato, K., Imaizumi, K., Takahashi, K., Ishida, H. and Ohno, H.
  • Journal Title: Biochem. Biophy. Res. Commun 379 Pages: 605-609
  • Peer Reviewed
• [Journal Article] Effect of Oligonol, low-molecular form of lychee fruit-derived polyphenol, on lipolysis in primary rat adipocytes (2009)
  • Author(s): Ogasawara, J., Kitadate, K., Nishioka, H., Fujii, H., Sakurai, T., Kizaki, T., Izawa, T., Ishida, H. and Ohno, H.
  • Journal Title: Phytother. Res (in press)
  • Peer Reviewed
• [Journal Article] Oligomerized grape seed polyphenols attenuate inflammatory changes due to antioxidative properties in coculture of adipocytes and macrophages (2009)
  • Author(s): Sakurai, T., Kitadate, K., Nishioka, H., Fujii, H., Kizaki, T., Kondoh, Y., Izawa ,T., Ishida, H., Radak, Z. and Ohno H.
  • Journal Title: J. Nutr. Biochem (in press)
  • Peer Reviewed
• [Journal Article] Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue (2009)
  • Author(s): Sakurai, T., et al.
  • Journal Title: Biochem. Biophys. Res. Commun. 379 Pages: 605-609
  • Peer Reviewed
• [Journal Article] Oligomenzed grape seed polyphenols attenuate inflammatory changesdue to antioxidative properties in coculture of adipocytes and mactophages (2009)
  • Author(s): Sahurai, T., et al.
  • Journal Title: J. Nutr. Biochem. (in press)
  • Peer Reviewed
• [Journal Article] Swimming training prevents induction of suppressor macrophages in mice during acute exposure to cold (2009)
  • Author(s): Ohno, H., et al.
  • Journal Title: Adv. Exerc. Sports Physiol. (in press)
  • NAID: 110007330710
  • Peer Reviewed
• [Journal Article] β-Adrenergic receptor regulates Toll-like receptor 4-induced TRIF-dependent late-phase NF-κB activation (2009)
  • Author(s): Kizaki, T., et al.
  • Journal Title: Mol. Immunol. (in press)
  • Peer Reviewed
• [Journal Article] Effect of Oligonol, low-molecular form of lychee fruit-derived polyphenol, on lipolysis in primary rat adipocytes (2009)
  • Author(s): Ogasawara, J., et al
  • Journal Title: Phytother. Res. (in press)
  • Peer Reviewed
• [Journal Article] Physical and functional interactions between hematopoietic cell-specific ETS transcription factors and homeodomain proteins (2009)
  • Author(s): Yamada, T., et al
  • Journal Title: Leuk. Res. 33 Pages: 483-489
  • Peer Reviewed
• [Journal Article] JNK- and IκB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro (2008)
  • Author(s): Takahashi, K., Yamaguchi, S., Shimoyama, T., Seki, H., Miyokawa, K., Katsuta, H., Tanaka, T., Yoshimoto, K., Ohno, H., Nagamatsu, S. and Ishida, H.
  • Journal Title: Am. J. Physiol. Endocrinol. Metab 294
  • Peer Reviewed
• [Journal Article] Adaptation of macrophages to exercise training improves innate immunity (2008)
  • Author(s): Kizaki, T., Takemasa, T., Sakurai, T., Izawa, T., Hanawa, T., Kamiya, S., Haga, S., Imaizumi, K. and Ohno, H.
  • Journal Title: Biochem. Biophys. Res. Commun 372 Pages: 152-156
  • Peer Reviewed
• [Journal Article] Amino acid mixture identical to vespa larval saliva increases both leptin secretion and basal lipolysis in rat adipocytes (2008)
  • Author(s): Ogasawara, J. and Abe, T.
  • Journal Title: Food Sci. Technol. Res. 14 Pages: 95-98
  • Peer Reviewed
• [Journal Article] β-adrenergic receptor regulates Toll-like receptor-4-induced nuclear factor-κB activation through β-arrestin 2 (2008)
  • Author(s): Kizaki, T., Izawa, T., Sakurai, T., Haga, S., Taniguchi, N., Tajiri, H., Watanabe, K., Day, N.K., Toba, K. and Ohno, H.
  • Journal Title: Immunology 124 Pages: 348-356
  • Peer Reviewed
• [Journal Article] Antioxidative effects of a new lychee fruit-derived polyphenol mixture, Oligonol, converted into a low-molecular form in adipocytes (2008)
  • Author(s): Sakurai, T., Nishioka, H., Fujii, H., Nakano, N., Kizaki, T., Radak, Z., Izawa, T., Haga, S. and Ohno, H.
  • Journal Title: Biosci. Biotechnol. Biochem. 72 Pages: 463-476
  • NAID: 10027524397
  • Peer Reviewed
• [Journal Article] The Supplementation of Oligonol, the new lychee fruit-derived polyphenol converting into a low-molecular form, has a positive effect on fatigue during regular track-and-field training in young athletes (2008)
  • Author(s): Ohno, H., Sakurai, T., Hisajima, T., Abe, S., Kizaki, T., Ogasawara, J., Ishibashi, Y., Imaizumi, K., Takemasa, T., Haga, S., Kitadate, K., Nishioka, H. and Fujii, H.
  • Journal Title: Adv. Exerc. Sports Physiol. 13 Pages: 93-99
  • NAID: 110006632543
  • Peer Reviewed
• [Journal Article] Adaptation of macrophages to exercise training improves innate immunity (2008)
  • Author(s): Kizaki, T., et al.
  • Journal Title: Biochem. Biophys. Res. Commun. 372 Pages: 152-156
  • Peer Reviewed
• [Journal Article] Acute exercise induces biphasic increase in respiretory mRNA in sheletal muscle (2008)
  • Author(s): Ikeda, S., et al.
  • Journal Title: Biochem. Biophys. Res. Commun. 368 Pages: 323-328
  • Peer Reviewed
• [Journal Article] Acute exereise increases expression of extracellular superoxide dismutase in skeletal musele and the aorta (2008)
  • Author(s): Hitomi, Y., et al
  • Journal Title: Redox Rep. 13 Pages: 213-216
  • Peer Reviewed
• [Journal Article] Amino acid mixture identical to vespa larval saliva increases both leptin secretion and basal lipolysis in rat adipocytes (2008)
  • Author(s): Ogasawara, J., et al
  • Journal Title: Food Sei. Technol. Res. 14 Pages: 95-98
  • Peer Reviewed
• [Journal Article] The supplementation of Oligonol, the new lychee fruit-derived polyphenol converting into a low-molecular form, Has a positive effeet on fatigue during regular track-and-field training in young athletes (2008)
  • Author(s): Ohno, H., et al.
  • Journal Title: Adv. Exere. Sports Physiol. 13 Pages: 93-99
  • Peer Reviewed
• [Journal Article] β adrenergie receptor regulates Toll-like receptor-4 induced nuelear faetor-κB aetivation through β-arrestin 2 (2008)
  • Author(s): Kizaki, T., et al.
  • Journal Title: Immunology 124 Pages: 348-356
  • Peer Reviewed
• [Journal Article] JNK-and IκB-dependent pathways resrulate MCP-1, not adiponectin,release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro (2008)
  • Author(s): Takahashi, K., et. al.
  • Journal Title: Am.J.Phvsiol.Endocrinol. Metab. (in press)
  • Peer Reviewed
• [Journal Article] β_<2^-> Adrenergic receptor regulates Toll-like recentor-4-induced nuclear factor-κB activation through β-arrestin 2 (2008)
  • Author(s): Kizaki, T., et. al.
  • Journal Title: Immunology (in press)
  • Peer Reviewed
• [Journal Article] The supplementation of Oligonol, the new lychee fruit-derived polyplienol converting into a low-molecular form, Has a positive effect on fatigue during regular track-and- field training in young athletes (2008)
  • Author(s): Ohno, H., et. al.
  • Journal Title: Adv.Exerc.Sports Physiol. 13 Pages: 93-99
  • Peer Reviewed
• [Journal Article] Antioxidative effects of a new lychee fruit-derived polyphenol mixture,Oligonol, converted into a low-molecular form in adipocytes (2008)
  • Author(s): Sakurai, T., et. al.
  • Journal Title: Biosci.Biotechnol.Biochem. 72 Pages: 463-476
  • NAID: 10027524397
  • Peer Reviewed
• [Journal Article] Acute exercise induces biphasic increase in respiratory mRNA in skeletal muscle (2008)
  • Author(s): Ikeda, S., et. al.
  • Journal Title: Biochem.Biophys.Res.Conmmn. 368 Pages: 323-328
  • Peer Reviewed
• [Journal Article] Gliclazide inhibits proliferation but stimulates differentiation of white and brown adipocytes (2007)
  • Author(s): Nakano, N., Miyazawa, N., Sakurai, T., Kizaki, T., Kimoto, K., Takahashi, K., Ishida, H., Takahashi, M., Suzuki, K. and Ohno, H.
  • Journal Title: J. Biochem. 142 Pages: 639-645
  • NAID: 10020095721
  • Peer Reviewed
• [Journal Article] Exercise before or after refeeding prevents refeeding-induced recovery of cell size after fasting with a different pattern of metabolic gene expressions in rat epididymal adipocytes (2007)
  • Author(s): Sakurai, T., Takei, M., Ogasawara, J., Ueda, H., Kizaki, T., Ohno, H. and Izawa, T.
  • Journal Title: Metabolism 56 Pages: 1270-1278
  • Peer Reviewed
• [Journal Article] JNK-and IκB-dependent pathways regulate MCP-1, not adiponectin, release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro (2007)
  • Author(s): Takahashi, K., et al.
  • Journal Title: Am. J. Physiol. Endocrinol. Metah. 294
  • Peer Reviewed
• [Journal Article] High altitude and oxidative stress (2007)
  • Author(s): Dosek, A., et. al.
  • Journal Title: Respir. Physiol. Neurobiol. 158 Pages: 128-131
  • Peer Reviewed
• [Journal Article] Functional roles of Fli-1, a member of the Ets family of transcription factors, in human breast malignancy (2007)
  • Author(s): Sakurai, T., et. al.
  • Journal Title: Cancer Sci. 98 Pages: 1775-1784
  • NAID: 10020119255
  • Peer Reviewed
• [Journal Article] Exercise before or after refeeding prevents refeeding-induced recovery of cell size after fasting with. a different pattern of metabolic gene expressions in rat epididymal adipocytes (2007)
  • Author(s): Sakurai, T., et. al.
  • Journal Title: Metabolism 56 Pages: 1270-1278
  • Peer Reviewed
• [Journal Article] SHP-2 positively regulates adipogenic differentiation in 3T3-L1 cells (2007)
  • Author(s): Uehara, T., et. al.
  • Journal Title: Int.J.Mol.Med. 19 Pages: 895-900
  • Peer Reviewed
• [Journal Article] Transcription resrulation of gene expression in rat pup brown adipose tissue in response to unloading or 2 G loading (2007)
  • Author(s): Watanabe, S., et. al.
  • Journal Title: Acta Astronautica. 60 Pages: 889-898
  • Peer Reviewed
• [Journal Article] Gliclazide inhibits proliferation but stimulates differentiation of white and brown adipocytes (2007)
  • Author(s): Nakano, N., et. al.
  • Journal Title: J.Biochem. 142 Pages: 639-645
  • Peer Reviewed
• [Journal Article] Characterization of pollen dispersion in the neighborhood of Tokyo, Japan in the spring of 2005 and 2006 (2007)
  • Author(s): Ishibashi, Y., et. al.
  • Journal Title: Int. J. Environ. Res. Public Health 5 Pages: 76-85
  • Peer Reviewed
• [Journal Article] Disposition of protein-bound 3-nitrotyrosine in rat plasma analysed by a novel tirotocol for HPLC-ECD (2007)
  • Author(s): Hitomi, Y., et. al.
  • Journal Title: J. Biochem. 41 Pages: 495-502
  • Peer Reviewed
• [Presentation] マクロファージスカベンジャー受容体1の発現はHIF-1 αによって調節される (2009)
  • Author(s): 白土健ら
  • Organizer: 第145回日本体力医学会関東地方会
  • Place of Presentation: 三鷹市
  • Year and Date: 2009-03-14
• [Presentation] 運動や運動トレーニングによるβ-アドレナリン受容体の適応機構 (2009)
  • Author(s): 井澤鉄也ら
  • Organizer: 第23回日本体力医学会近畿地方会
  • Place of Presentation: 吹田市
  • Year and Date: 2009-01-31
• [Presentation] New lychee fruit-derived polyphenol Oligonol converted into a low-molecular form improves exercise-induced fatigue (2009)
  • Author(s): Sakurai, T. et.al.
  • Organizer: 3rd Symposium of Nutrition, Oxygen Biology and Medicine, Apr
  • Place of Presentation: Paris.(8-10)
• [Presentation] 脂肪組織由来幹細胞の脂肪および血管内皮細胞への分化に対する運動トレーニングの影響 (2009)
  • Author(s): 櫻井拓也, ほか
  • Organizer: 第79回日本衛生学会学術総会
  • Place of Presentation: 東京
• [Presentation] 急性運動による脂肪細胞の脂肪分解反応のメカニズム (2009)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 第79回日本衛生学会学術総会
  • Place of Presentation: 東京
• [Presentation] 運動トレーニングによる免疫機能の修飾 : マクロファージを中心として (2009)
  • Author(s): 木崎節子, ほか
  • Organizer: 文部科学省学術フロンティア研究プロジェクト「ライフステージに応じた健康増進と多様性保持」第3 回研究発表会
  • Place of Presentation: 所沢
• [Presentation] 低酸素誘導因子(HIF)-laによるマクロファージスカベンジャー受容体の発現調節 (2009)
  • Author(s): 白土健ら
  • Organizer: 文部科学省学術フロンティア研究プロジェクト「ライフステージに応じた健康増進と多様性保持」第3回研究発表会
  • Place of Presentation: 所沢市
• [Presentation] 運動トレーニングによる免疫機能の修飾 : マクロファージを中心として (2009)
  • Author(s): 木崎節子ら
  • Organizer: 文部科学省学術フロンティア研究プロジェクト「ライフステージに応じた健康増進と多様性保持」第3回研究発表会
  • Place of Presentation: 所沢市
• [Presentation] 脂肪細胞サイズとアデイポカイン遺伝子発現との関係に及ぼす運動トレーニングの影響 (2009)
  • Author(s): 井澤鉄也ら
  • Organizer: 文部科学省学術フロンティア研究プロジェクト「ライフステージに応じた健康増進と多様性保持」第3回研究発表会
  • Place of Presentation: 所沢市
• [Presentation] 急性運動による脂肪細胞の脂肪分解反応のメカニズム (2009)
  • Author(s): 小笠原準悦ら
  • Organizer: 第79回日本衛生学会学術総会
  • Place of Presentation: 東京都
• [Presentation] 脂肪組織由来幹細胞の脂肪および血管内皮細胞への分化に対する運動トレーニングの影響 (2009)
  • Author(s): 櫻井拓也ら
  • Organizer: 第79回目本衛生学会学術総会
  • Place of Presentation: 東京都
• [Presentation] New lychee fruit-derived polyphenol Oligonol converted into a low-molecular form improves exercise-induced fatigue (2009)
  • Author(s): Sakurai, T., et al
  • Organizer: 3rd Symposium of Nutrition, Oxygen Biology and Medicine
  • Place of Presentation: Paris
• [Presentation] β作動性脂質代謝とユビキチン (2008)
  • Author(s): 小笠原準悦ら
  • Organizer: 第1回脳・神経・内分泌から運動の意義を考える会
  • Place of Presentation: 別府市
  • Year and Date: 2008-09-17
• [Presentation] ラット初代培養脂肪細胞の脂肪分解反応に及ぼすオリゴノールの効果 (2008)
  • Author(s): 小笠原準悦ら
  • Organizer: Functional Polyphenol Symposium : Novel Use of Low Molecular Polyphenol : Oligonol
  • Place of Presentation: 札幌市
  • Year and Date: 2008-07-25
• [Presentation] ライチ由来新規低分子化ポリフェノールOligonolは疲労改善効果をもつ (2008)
  • Author(s): 櫻井拓也ら
  • Organizer: 国際食品機能学会2008
  • Place of Presentation: 東京都
• [Presentation] 急性運動と脂肪細胞のホルモン感受性リパーゼの発現変化 (2008)
  • Author(s): 小笠原準悦ら
  • Organizer: 第63回日本体力医学会大会
  • Place of Presentation: 別府市
• [Presentation] 運動負荷パターンの差異が酸化ストレスにおよぼす影響 (2008)
  • Author(s): 長澤純一ら
  • Organizer: 第63回日本体力医学会大会
  • Place of Presentation: 別府市
• [Presentation] 運動強度の差異と酸化ストレス (2008)
  • Author(s): 高井俊秀ら
  • Organizer: 第63回日本体力医学会大会
  • Place of Presentation: 別府市
• [Presentation] 一過性持久性運動による血管新生関連因子の発現変化 (2008)
  • Author(s): 町田正直ら
  • Organizer: 第63回日本体力医学会大会
  • Place of Presentation: 別府市
• [Presentation] 運動トレーニングは脂肪組織由来幹細胞の脂肪細胞への分化を抑制する (2008)
  • Author(s): 櫻井拓也ら
  • Organizer: 第6回日本予防医学会学術総会
  • Place of Presentation: 東京都
• [Presentation] 骨格筋に対するin vivo遺伝子導入法によるcalcineurin制御タンパクRcan1発現制御の検討 (2008)
  • Author(s): 人見嘉哲ら
  • Organizer: 第81回日本生化学会大会
  • Place of Presentation: 神戸市
• [Presentation] Oxidative stress in adipocytes is reduced by new lychee-derived polyphenol Oligonol converted into a low-molecular form (2008)
  • Author(s): Sakurai, T., et. al.
  • Organizer: HSSRC/AIST-NIEHS/NIH Joint International Symposium
  • Place of Presentation: Osaka
• [Presentation] 運動トレーニングによって脂肪組織内酸化ストレスは軽減される (2008)
  • Author(s): 桜井 拓也, 他
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 熊本
• [Presentation] 登山は中高年にこそ相応しい-登山と恋愛は総合芸術 (2007)
  • Author(s): 大野 秀樹
  • Organizer: 第141回日本体力医学会関東地方会大会
  • Place of Presentation: 八王子
  • Year and Date: 2007-12-01
• [Presentation] 脂肪組織の酸化ストレスは運動トレーニングによって軽減される (2007)
  • Author(s): 桜井 拓也, 他
  • Organizer: 第141回日本体力医学会関東地方会大会
  • Place of Presentation: 八王子
  • Year and Date: 2007-12-01
• [Presentation] 脂肪細胞におけるライチ由来新規低分子化ボリフェノールOligonolの抗酸性作用 (2007)
  • Author(s): 桜井 拓也, 他
  • Organizer: 第36回杏林医学会総会
  • Place of Presentation: 三鷹
  • Year and Date: 2007-11-17
• [Presentation] New lychee-derived polyphenol Oligonol converted into a low-molecularform reduces oxidative stress in adinocytes (2007)
  • Author(s): Sakurai, T., et. al.
  • Organizer: 16th European Congress on Obesity
  • Place of Presentation: Budapest
• [Presentation] 職域における2型糖尿病発症予防研究第3報〜介入1年後の検討〜 (2007)
  • Author(s): 根本 浩一郎, 他
  • Organizer: 第80回日本産業衛生学会
  • Place of Presentation: 大阪
• [Presentation] 脂肪細胞の酸化ストレスはライチ由来新規低分子化ポリフェノールOligonolによって軽減される (2007)
  • Author(s): 桜井 拓也, 他
  • Organizer: 第4回国際食品機能学会
  • Place of Presentation: 東京
• [Presentation] 中高年の継続的登山習慣の意義:基調講演:登山と恋愛は総合芸術 (2007)
  • Author(s): 大野 秀樹
  • Organizer: 第27回日本登山医学シンポジウム
  • Place of Presentation: 蔵王町
• [Presentation] ライチ由来新規低分子化ポリフェノールOligonolは脂肪細胞に対して抗酸化・抗炎症作用をもつ (2007)
  • Author(s): 桜井 拓也, 他
  • Organizer: 第15回AHCC研究会国際研究報告会
  • Place of Presentation: 札幌
• [Presentation] 運動トレーニングは脂肪組織の酸化ストレスを軽減する (2007)
  • Author(s): 桜井 拓也, 他
  • Organizer: 第15回日本運動生理学会大会
  • Place of Presentation: 弘前
• [Presentation] 経口糖尿病薬クリクフジドの多機能性 (2007)
  • Author(s): 中野 法彦, 他
  • Organizer: レドヅクス生命科学第170委員会第18回研究会
  • Place of Presentation: 蔵王町
• [Presentation] ライチ由来新規低分子化ポリフェノールOligonolによる疲労改善効果 (2007)
  • Author(s): 桜井 拓也, 他
  • Organizer: 第62回日本体力医学会大会
  • Place of Presentation: 秋田
• [Presentation] 乳酸菌が骨格筋におけるVEGF発現に及ぼす影響 (2007)
  • Author(s): 町田正直, 他
  • Organizer: 第62回日本体力医学会大会
  • Place of Presentation: 秋田
• [Presentation] 運動の強度および時間と酸化ストレス (2007)
  • Author(s): 長澤 純一, 他
  • Organizer: 第62回日本体力医学会大会
  • Place of Presentation: 秋田
• [Presentation] 肥満予防に対する骨格筋と脂肪組織の役割:脂肪組織と骨格筋の密話分解反応 (2007)
  • Author(s): 井澤 鉄也, 他
  • Organizer: 第62回日本体力医学会大会
  • Place of Presentation: 秋田
• [Presentation] 脂肪組織由来幹細胞に及ぼす運動トレーニンクの影響 (2007)
  • Author(s): 井澤 鉄也, 他
  • Organizer: 第62回日本体力医学会大会
  • Place of Presentation: 秋田
• [Presentation] ライチ由来新規低分子化ポリフェノール(Oligonol)のスポーツ選手に対する疲労改善効果 (2007)
  • Author(s): 北舘 健太郎, 他
  • Organizer: 第18回日本臨床スポーツ医学会学術集会
  • Place of Presentation: 別府
• [Presentation] 運動トレーニングの脂肪組織内酸化ストレス軽減効果 (2007)
  • Author(s): 桜井 拓也, 他
  • Organizer: 第5回日本予防医学会学術総会
  • Place of Presentation: 指宿
• [Presentation] Antioxidative/anti-inflammatory effects of the new lychee-derived polyphenol Oligonol converted into a low-molecular form in white adipose tissue (2007)
  • Author(s): Sakurai.T, et. al.
  • Organizer: 3rd International Conference on Polyphenols and Health
  • Place of Presentation: Kyoto, Japan
• [Presentation] 脂肪細胞の増殖・分化に対するグリクラジドの機能の解析 (2007)
  • Author(s): 中野 法彦, 他
  • Organizer: 第80回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] カルシニューリン制御タンパクRcn1による骨格筋活動のモニター (2007)
  • Author(s): 人見 嘉哲, 他
  • Organizer: 文部科学省学術フロンティア研究プロジェクト第2回研究会
  • Place of Presentation: 所沢
• [Presentation] 脂肪組織由来幹細胞に及ぼす運動トレーニングの影響 (2007)
  • Author(s): 井澤 鉄也, 他
  • Organizer: 文部科学省学術フロンティア研究プロジェクト第2回研究会
  • Place of Presentation: 所沢
• [Book] 登山の医学ハンドブック (2009)
  • Author(s): 大野秀樹ら
  • Publisher: 杏林書院(印刷中)
• [Book] ラット初代培養脂肪細胞の脂肪分解反応に及ぼすオリゴノールの効果(In : Proc. of Functional Polyphenol Symposium : Novel Use of Low Molecular Polyphenol) (2008)
  • Author(s): 小笠原準悦、櫻井拓也、北舘健太郎、西岡浩、藤井創、白土健、石橋義永、木崎節子、井澤鉄也、斎藤大蔵、今泉和彦、大野秀樹
  • Publisher: Oligonol、札幌
• [Book] Proc. of Functional Polyphenol Symposium : Novel Use of Low Molecular Polyphenol : Oligonol (2008)
  • Author(s): 小笠原準悦ら
  • Total Pages: 77
  • Publisher: AHCC Research Association
• [Book] 栄養科学シリーズNEXT 公衆衛生学 (2008)
  • Author(s): 大野 秀樹, 他
  • Total Pages: 181
  • Publisher: 講談社
• [Book] 体力とはなにか (2007)
  • Author(s): 大野 秀樹, 他
  • Total Pages: 1
  • Publisher: ナップ