Search for Natural Products Which Enhance the Effect of Tumor Suppressor Protein
Project/Area Number |
19310140
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Living organism molecular science
|
Research Institution | Chiba University (2008-2009) Kanazawa University (2007) |
Principal Investigator |
TSUKAMOTO Sachiko Chiba University, 大学院・生命科学研究部, 教授 (40192190)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2007: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
|
Keywords | ユビキチン / プロテアソーム / がん抑制遺伝子産物 / 抗がん剤 / p53 / 天然低分子化合物 / 海洋生物 / 海洋無脊椎動物 / 海洋由来微生物 / がん挿制遺伝子 / 天然資源 / 低分子化合物 / がん治療薬 / Mdm2 / COP1 / Ubc13-Uev1A |
Research Abstract |
p53 plays an important role on suppression of tumor, and the drugs which enhance the effect of p53 will treat a various cancer. In this study, we search for compounds, which inhibit the interactions of p53-Hdm2 and Ubc13-Uev1A from marine organisms.
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Report
(4 results)
Research Products
(44 results)