Development of Laser desorption/ionization mass spectrometry using 2D ordered nanoparticles on substrates
| Project/Area Number |
19350045
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Kansai University |
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Principal Investigator |
ARAKAWA Ryuichi Kansai University, 化学生命工学部, 教授 (00127177)
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| Co-Investigator(Kenkyū-buntansha) |
KAWASAKI Hideya 関西大学, 化学生命工学部, 准教授 (50322285)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | レーザー脱離イオン化質量分析法 / ナノ粒子 / SALDI-MS / 環境分析 / バイオ分析 / レーザー脱離イオン化 / 金属ナノ粒子 / ソフトイオン化 / 環境化学物質 / 磁性ナノ粒子 / 表面修飾 / 金ナノ粒子 / 交互積層法 / ZnOナノ粒子 / 白金ナノ粒子 / MALDI-MS |
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| Research Abstract |
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) using organic matrices is a soft ionization technique that causes very less fragmentation of the analytes. However, matrix ion interface and detector saturation are inevitable in the MALDI-MS analysis of low-mass molecules (<m/z 500), and this makes the characterization of small molecules difficult despite the significance of such characterization. As an approache involving the use of organic-matrix-free LDI-MS for analyzing small molecules in a MALDI instrument, we have investigated a new and facile method for synthesizing two-dimensional (2D) nanoparticles on substrates for the applications of surface-assisted laser desorption/ionization-mass spectrometry (SALDI-MS). New types of nanostructured substrates for organic-matrix-free LDI-MS have been found : (1) Platinum nanoflowers, (2) rod-like zinc oxide nanoparticles,, (3) urea-modified titania nanoparticles, and (4) FePtCu magnetic nanoparticles. The feasibility of using these nanomaterials for SALDI-MS has been demonstrated.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article]2009
Author(s)
荒川隆一
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Journal Title
金属ナノ・マイクロ粒子の形状・構造制御技術(シーエムシー出版)
Pages: 249-262
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